#peripheralbloodsmear

[robbialy]

A day in a haematopathologist’s life: • From • @pathnuggets Promonocytes in peripheral blood - here you can see several promonocytes. Promonocytes have delicately folded nuclei and fine chromatin. Sometimes you can also see small nucleoli. Promonocytes are considered blast equivalents. Acute monocytic leukemia will have mostly promonocytes in the marrow aspirate. Monocytes tend to mature a little bit when they move into the blood so in some acute monocytic leukemias you may see some immature monocytes and more mature monocytes in the blood. #pathnuggets #pathologynuggets #pathology #pathologyeducation #peripheralbloodsmear #hemepath #hematopathology https://www.instagram.com/p/Cekw2y2D3kSZJizU72kx0bR0WqiRh8RTRW7jMw0/?igshid=NGJjMDIxMWI=

[robbialy]

From • @pathnuggets Acute myeloid leukemia without maturation in the peripheral blood. Here we can see several blasts in this image collage. The blasts have some small azurophilic granules. Well defined Auer rods are not seen. You would need flow cytometry to say for sure these are myeloid blasts. The blasts will usually have at least partial expression of myeloperoxidase along with other myeloid associated markers such as CD13, CD33, and CD117. Most cases have CD34 expression too which can also be performed by immunohistochemistry. Can sometimes have some more lymphoid associated markers detected including CD7, CD2, CD56, and CD19. On marrow aspirate maturing myeloid precursors will be less than 10% of the differential. #pathnuggets #pathologynuggets #pathology #pathologyeducation #peripheralbloodsmear #hemepath #hematopathology https://www.instagram.com/p/CeiXAJXjnTqLc_fpbAQX-3OMTpBeRAvKMFiDDo0/?igshid=NGJjMDIxMWI=