Benefits and disadvantages of PET imaging methods.
The sensitivity of this technique allows for a lower dose of the tracer and therefore, and therefore results can be quantitative. Often if the required tracer dosage compared to the receptor concentration is low a linear relationship between signal and receptor concentrations can be established.
A versatile procedure with tracers for many purposes.
A positron annihilation emits two gamma rays that are directed at almost 180 degree vectors from the point of decomposition, allowing a detector to find the origin of the radiopharmaceutical by matching the two gamma rays together.
Exposure to ionizing radiation for one study similar to that of living in Denver, CO for one year.
Expensive, the average for an uninsured patient, ranges from $1000 to $20,000 according to NewChoiceHealth.com[3] .
A lot of the tracers are still investigational.
PET (positron emission tomography)uses chemicals labelled with a positron (e+) emitting isotope
Commonly used PET isotopes and their benefits
Inexpensive to produce (no cyclotron necessary)
Chelation techniques can be simple
Iodine-131 (some gamma radiation)
longer half-life allows for longer shipment times, or more complicated experimental procedures
Fluorine-18 eg. Fluorodeoxyglucose
110 min. half life allows for relatively complex chemical synthesis and purification techniques.
Decomposition products are relatively benign with nearly 100% conversion from F-18 to the positron emitting nuclear reaction.
Indium-111 eg. Labeled Leukocytes
Half life of 20.3 minutes still allows for complex multi-step processes.
Most molecules are available in a labelled form due to the pervasiveness of Carbon, and the convenience of the reagents that can be used.