#prodrug

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You. I love you

I LOVE U TOO LUCKY!!! we do this (artist is @/synd-ecco on tumblr!)

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Scientists Create Turmeric Curcumin Prodrug With Anti-Tumor Effects And No Toxicity

Curcumin is a natural polyphenol whose limited bioavailability and low stability have dampened its prospects in clinical use till now.

Turmeric, the spice associated with cancer treatment, has always been hyped. However, it has never been converted into a viable drug. Now, a new study has been successful in creating a prodrug form of the wonder spice.

Turmeric, more specifically, its molecule curcumin is the ingredient that has been proven to successfully fight against tumors in several preclinical models. But when it comes to manufacturing it in medicine form, pharmaceutical companies have faced many hurdles.

But a team of researchers from Kyoto University has been able to develop a prodrug form of curcumin called  TBP1901  that has shown anti-tumor effects with no toxicity. Their study was published in the European Journal of Pharmacology.

“Curcumin has long been used as a spice or food coloring, so we expect to see minimal side effects,” lead author Masashi Kanai said, reported SciTechDaily.

Curcumin is a natural polyphenol whose limited bioavailability and low stability have dampened its prospects in clinical use till now.

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[ijtsrd]

A Comprehensive Review on Drug Delivery Approach to Central Nervous System

BY Parth Nikam | Rishikesh Bachhav "A Comprehensive Review on Drug Delivery Approach to Central Nervous System"

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-6 , October 2021,

URL: https://www.ijtsrd.com/papers/ijtsrd46375.pdf

Paper URL : https://www.ijtsrd.com/pharmacy/analytical-chemistry/46375/a-comprehensive-review-on-drug-delivery-approach-to-central-nervous-system/parth-nikam

callforpaperpharmacy, pharmacyjournal, internationalpeerreviewedjournal

The brain is a delicate organ, and evolution built very efficient ways to protect it. Unfortunately, the same mechanisms that protect it against intrusive chemicals can also frustrate therapeutic interventions. Many existing pharmaceuticals are rendered ineffective in the treatment of cerebral diseases due to our inability to effectively deliver and sustain them within the brain. General methods that can enhance drug delivery to the brain are, therefore, of great interest. Despite aggressive research, patients suffering from fatal and or debilitating central nervous system CNS diseases, such as brain tumors, HIV encephalopathy, epilepsy, cerebrovascular diseases and neurodegenerative disorders, far outnumber those dying of all types of systemic cancer or heart disease. The clinical failure of much potentially effective therapeutics is often not due to a lack of drug potency but rather to shortcomings in the method by which the drug is delivered. Treating CNS diseases is particularly challenging because a variety of formidable obstacles often impede drug delivery to the brain and spinal cord. By localizing drugs at their desired site of action one can reduce toxicity and increase treatment efficiency. In response to the insufficiency in conventional delivery mechanisms, aggressive research efforts have recently focused on the development of new strategies to more effectively deliver drug molecules to the CNS. This review intends to detail the recent advances in the field of brain targeting, rational drug design approach and drug delivery to CNS. To illustrate the complexity of the problems that have to be overcome for successful brain targeting, a brief intercellular characterization of the blood-brain barrier BBB is also included. 

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What is Prodrug | Full explained Bangla | Pharmacology | Pharmacy

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Pro drug

It is a type of drug which is inactive as such and need conversion in the body to one or more active metabolites.

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Pioneering red light-activated anti-tumor prodrug reduces side effects -- ScienceDaily

Pioneering red light-activated anti-tumor prodrug reduces side effects — ScienceDaily

Most of the current clinical anti-tumor drugs used in chemotherapy move around in the patient’s blood after intake and are unable to pinpoint the targeted tumor. As a result, while killing the tumor cells, the healthy cells may also be killed as “collateral damage,” leading to undesired side effects. Aiming to overcome this problem, Dr Zhu Guangyu, Associate Professor of Department of Chemistry,…

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Capecitabine - a prodrug which is metabolised by enzymes in the body to 5-fluorouracil (5-FU). 5-FU is a thymidylate synthase inhibitor, hence inhibiting the synthesis of thymidine monophosphate which is essential for DNA synthesis.

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Fostamatinib - a prodrug of the active compound tamatinib which is an inhibitor of the enzyme spleen tyrosine kinase (Syk). It is a target for the inhibition of various autoimmune conditions and potentially used for the treatment of rheumatoid arthritis, lymphoma, and other autoimmune disease.