#psoriasin

[myotcstore]

http://www.myotcstore.com/store/p/36945-Psoriasin-Multi-Symptom-Psoriasis-Relief-Ointment-113-Grams Buy Psoriasin Multi-Symptom Psoriasis Relief Ointment - 113 Grams at myotcstore.com

[itsmisslaceynoel]

I had a DELIGHTFUL time hanging out with @justsandsworld, and his beautiful lil fur baby Teddy! Thank you so much for having me over!! It was fun to collaborate and get countless dog kisses lol. Buddy and Teddy need a play date someday. 💙 GO TO THE LINK IN MY BIO, OR HERE https://youtu.be/rclp8rizoNs TO WATCH! We talk about our sufferings with a skin disease that has no cure. 💙 #SandersKennedy #teddy #familyphoto #psoriasis #skinproblems #skin #theskinimin #youtube #youtuber #psoriasin #autoimmunedisease #autoimmunedisorder #health #healthandwellness 💙💙💙

[jennieyuenblog]

Product review: Winter Skin Rescue

[the-crinkle]

Psoriasin, wallflower of the body fluids?

My recent post has me thinking about body fluids. Actually I think about body fluids a lot. they’re just so interesting how their compositions are so specialized for the task!

We produce antimicrobial substances everywhere we might find microbes (mouth, eyes, ear canals, butt). Bacteria and viruses sound pretty scary but we’ve evolved all kinds of clever ways to keep them out. 

Your skin is your barrier against most infection but we get minor cuts and scrapes all the time. When you cut your finger on the cable bill the site of your wound will produce psoriasin. Once your skin is breached, your keratinocytes help out by contributing psoriasin to the mix of fluids working to move bacteria out of the area before sealing up and starting repair. It’s also why infection rarely occurs for sunburns even though blistering can expose you. Skin is so helpful!

As I was gathering sources I found an interesting article that talks about Psoriasin as the main E. coli fighting substance on your tongue. I tend to think of the tongue as a very tough muscle and not super susceptible to bacterial infection, partly due to the constant saliva wash, but also because it feels pretty solid (especially compared to an eyelid). Even when bitten it seems to recover quickly. But of course your tongue is just as susceptible to injury as other parts of you. Have you ever eaten Cap’n Crunch? That will mess your mouth up. And if you aren’t a fastidious wiper and go to town on some cheese puffs, you’re definitely at risk for E. coli gettin’ in. 

I also found several articles that outlined how psoriasin is used as a biomarker to determine the presence of bladder cancer. I couldn’t find any articles that detailed if the cells of the bladder produce psoriasin normally,  so I’m going to guess it does secrete some considering proximity  and likelihood of E. coli exposure. But it must be in very small amounts or not secreted in urine.  as its presence in urine indicates a state of disease. But I wonder why it starts being produced, or produced in greater amounts when the cancer arises? More research required!

It would make sense if the urinary tract produced psoriasin. Why doesn’t it? This seems like an ideal location for psoriasin! Vaginal fluid contains small amounts of psoriasin so why doesn’t the urinary tract? UTI’s affect so many women! Evolution, I’m putting in a feature request!

I’m super curious to know why we haven’t synthesized psoriasin for use in hand sanitizers. Protein synthesis is challenging but this seems like an ideal solution! Maybe instead of using broad spectrum β-Lactam antibiotics for UTI treatment we could develop a psoriasin based treatment gel and treat the region instead of the whole body. Antibiotic resistance and overuse is a huge issue and perhaps this is the way to fight bacterial exposure in the future; using tailored, amped up fluids that are already working for us. I hope so! 

References: 

Gläser, Regine, et al. “Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection.” Nature immunology 6.1 (2004): 57-64.

Thongboonkerd, V., et al. “Urinary proteomics and biomarker discovery for glomerular diseases.” (2004): 292-307.

Meyer, J. E., et al. “Psoriasin (S100A7) is a principal antimicrobial peptide of the human tongue.” Mucosal immunology 1.3 (2008): 239-243.

Lee, Kathleen C., and Richard L. Eckert. “S100A7 (Psoriasin)–mechanism of antibacterial action in wounds.” Journal of Investigative Dermatology 127.4 (2006): 945-957.

Mildner, M., et al. “Psoriasin (S100A7) is a major Escherichia coli-cidal factor of the female genital tract.” Mucosal immunology 3.6 (2010): 602-609.

Brodersen, Ditlev Egeskov, et al. “EF-hands at atomic resolution: the structure of human psoriasin (S100A7) solved by MAD phasing.” Structure 6.4 (1998): 477-489.

[saleyaa]

Manage Psoriasis the Natural Way

Manage Psoriasis the Natural Way

We are not making any bold claims that the Psoriasis condition can be totally cured. We all know very well that there is no permanent cure for this skin condition. We need to search for measures that help us to control this problem effectively so that we do not have to suffer the ugly skin manifestations. This can certainly be achieved.We CAN control the Psoriasis out breaks effectively.This…

View On WordPress

[ebkitibki]

Manage Psoriasis the Natural Way

Manage Psoriasis the Natural Way

We are not making any bold claims that the Psoriasis condition can be totally cured. We all know very well that there is no permanent cure for this skin condition. We need to search for measures that help us to control this problem effectively so that we do not have to suffer the ugly skin manifestations. This can certainly be achieved.We CAN control the Psoriasis out breaks effectively.This…

View On WordPress

[saleyaa]

Manage Psoriasis the Natural Way

Manage Psoriasis the Natural Way

We are not making any bold claims that the Psoriasis condition can be totally cured. We all know very well that there is no permanent cure for this skin condition. We need to search for measures that help us to control this problem effectively so that we do not have to suffer the ugly skin manifestations. This can certainly be achieved.We CAN control the Psoriasis out breaks effectively.This…

View On WordPress

[ebkitibki]

Manage Psoriasis the Natural Way

Manage Psoriasis the Natural Way

We are not making any bold claims that the Psoriasis condition can be totally cured. We all know very well that there is no permanent cure for this skin condition. We need to search for measures that help us to control this problem effectively so that we do not have to suffer the ugly skin manifestations. This can certainly be achieved.We CAN control the Psoriasis out breaks effectively.This…

View On WordPress