#pwlc

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Fascinating long Covid research study from the Netherlands published in early January. Image is from Guardian article: "Long Covid causes changes in body that make exercise debilitating – study. Experts say severe muscle damage, mitochondrial problems and microclots may explain impact of working out"

Long Covid causes changes in body that make exercise debilitating – study

Experts say severe muscle damage, mitochondrial problems and microclots may explain impact of working out

Full research paper can be read here: "Muscle abnormalities worsen after post-exertional malaise in long COVID"

Muscle abnormalities worsen after post-exertional malaise in long COVID - Nature Communications

In this longitudinal, case-controlled, cohort design study, authors show that post-exertional malaise is associated with severe exercise-ind

"This study highlights novel pathways that help to understand the pathophysiology of post-exertional malaise in patients suffering from long COVID and other post-infectious diseases."

Press release:

Tiredness experienced by Long-COVID patients has a physical cause

Researchers from Amsterdam UMC and Vrije Universiteit Amsterdam (VU) have discovered that the persistent fatigue in patients with long-COVID

Discussion thread on the Science for ME forum

Muscle abnormalities worsen after post-exertional malaise in long COVID, 2023/4, Wüst, van Vugt, Appelman et al

Muscle Abnormalities Contribute to Post-Exertional Malaise in Long COVID A poster presentation of the very soon to be published work by Rob

Twitter thread by corresponding author:

Includes: "We are now seeing if something similar happens in patients with ME, and hope to include muscle biopsies from patients with severe ME as well in the near future"

"This collaboration between @amsterdamumc, @VUamsterdam , @VU_FGB, and @AMSmovement would not have been possible without the help of so many students, colleagues, and private funders. We also acknowledge the contribution of @PlzSolveCFS , Patient-Led Research Collaborative , and @ZonMw for future work! 2/m"

"Professor Steve Griffin, of Leeds University, said the study suggests “the approach to treating conditions such as long Covid, ME and CFS [myalgic encephalomyelitis and chronic fatigue syndrome] using graded exercise regimens is entirely flawed. Moreover, it appears that over-exercising under these circumstances is actually directly damaging”."

Long Covid patients risk serious long-term injury from running or cycling

A new study helps to explain why people with long Covid can feel such high levels of fatigue

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ME/CFS = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome LC = Long Covid PEM = post-exertional malaise

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Extract from Episode 73: Dr Rob Wüst - Post-exertional Malaise (P.E.M) TLC Sessions - Living with Long Covid

Full episode here: https://podcasts.apple.com/gb/podcast/episode-73-dr-rob-w%C3%BCst-post-exertional-malaise-p-e-m/id1574768076?i=1000651198002

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"Study helps explain post-COVID exercise intolerance: Exercise intolerance is one symptom associated with long COVID. A new study helps explain its cause" (December 19)

Study helps explain post-COVID exercise intolerance

Exercise intolerance is one symptom associated with long COVID. A new study helps explain its cause.

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#Covid  /  #LongCovid research from the UK

Press release: Ongoing brain injury caused by #COVID19 may not always be detected by routine tests

<p>A new study published today (22 December 2023) in <em>Nature Communications</em> details that markers of brain injury are present in the

Free fulltext:

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses - Nature Communication

COVID-19 can be associated with neurological complications. Here the authors show that markers of brain injury, but not immune markers, are