#signs&symptomsofcoronavirus

[weedforsaleonlineusa]

How Far Can Chloroquine & Hydroxychloroquine Cure Corona Virus?

Key takeaways: Hydroxychloroquine and chloroquine are two medications that have been used for many decades to treat malaria and autoimmune conditions like rheumatoid arthritis and lupus.There is not enough medical data at this time to prove that hydroxychloroquine and chloroquine work for COVID-19 — while some small studies suggest the medications may be helpful, other studies saw no benefit.There have been no studies showing that these medications work for prevention, and the FDA has issued a warning for serious heart-related side effects if hydroxychloroquine or chloroquine are taken outside of a hospital setting for COVID-19.There’s now a shortage of hydroxychloroquine and chloroquine, which means that people who normally take these medications to manage their health are having a harder time getting the treatment they need. Hydroxychloroquine (Plaquenil) and chloroquine are two medications that have recently been making headlines as possible treatments for the coronavirus disease (COVID-19). Do these medications actually work against COVID-19? Here’s what we know.

What is hydroxychloroquine, and what is chloroquine?

Hydroxychloroquine is a medication first approved to treat malaria, an infection caused by a parasite. It is similar in structure to chloroquine, which was first approved by the FDA in 1949.  SHOP CHLOROQUINE NOW Vaccines & Drugs: The Way Forward for Covid-19 5 Important Factors To Note About The Corona Virus Hydroxychloroquine, approved in 1955, is typically preferred over chloroquine because it has fewer side effects. Side effects for both medications, which are more common at higher doses and with long-term use, include: Irreversible visual changesLong QT or QT prolongation (abnormal heart rhythm)Muscle weakness or nerve painHypoglycemia (low blood glucose)Worsening of psoriasis

What do hydroxychloroquine or chloroquine usually treat?

Hydroxychloroquine and chloroquine were first used to prevent or treat malaria. Both are available as pills that are taken by mouth. Hydroxychloroquine is also approved for long-term use in rheumatoid arthritis and lupus.

The dosage varies depending on what the medications are being used for. On the low end, hydroxychloroquine is taken as 400 mg orally once a week for malaria prevention and should be continued for 4 weeks after leaving an endemic area. On the high end, hydroxychloroquine is taken as 200 mg to 400 mg daily for rheumatoid arthritis.

Why are hydroxychloroquine and chloroquine being mentioned with COVID-19?

Recent in vitro studies (studies done in a petri dish or test tube rather than in animals or humans) have shown that both hydroxychloroquine and chloroquine have antiviral properties against SARS-CoV-2, the virus that causes COVID-19. In these studies, these medications worked by interfering with the chemical environment of human cell membranes. This blocked the virus from entering and multiplying inside the cells. A medication working in vitro does not always mean that it will work once inside a human body. Nonetheless, based on these early findings, hospitals worldwide have begun using hydroxychloroquine and chloroquine for patients with COVID-19. On March 28, 2020, the FDA issued an Emergency Use Authorization (EUA) that allows providers to request a supply of hydroxychloroquine or chloroquine for hospitalized patients with COVID-19 who are unable to join a clinical trial. The EUA does not mean that the FDA has approved these medications for the treatment of COVID-19. The intent of the EUA is to help increase access to these medications by allowing doctors to request a supply from the Strategic National Stockpile for these specific cases.

What do research studies say about hydroxychloroquine, chloroquine, and COVID-19?

Data is still extremely limited. We need more research to determine the best dose, when to give it and for how long, and how the risks and benefits of these medications stack up in the fight against COVID-19. Large, randomized, controlled trials (the gold standard for clinical trials) are needed to confirm many of the findings summarized below. HOW TO ORDER HERBAL & LIQUID INCENSE? Vaccines & Drugs: The Way Forward for Covid-19 5 Important Factors To Note About The Corona Virus Several studies have gained a lot of attention in recent media reports. We break it down between those that suggest the medications work compared to those that did not see a benefit. (Please note that even though results are being shared, few have been accepted into peer-reviewed medical journals.) Studies with positive results for hydroxychloroquine and chloroquine in COVID-19 Study 1 – March 16, 2020 Researchers from China reported in a letter that over 100 people with COVID-19 have been treated with chloroquine. These patients had less severe disease and a shorter illness duration compared to those who did not receive chloroquine. However, results from these studies are not yet available, nor do we have a lot of information about the type of people who received this drug, or what dose they took and for how long. Study 2 – March 20, 2020 A small study in France reported that people who got 600 mg of hydroxychloroquine had a lower amount of the virus (viral load) in the body. The problem with this study is that comparisons were made between patients at different hospitals. This makes it difficult to know if improvements were because of hydroxychloroquine or other things. And, of the 26 people who initially got hydroxychloroquine, 6 people (23%) had to stop treatment because of nausea, worsening disease, leaving the hospital, or death. Six people in this study also received azithromycin (a common antibiotic) with hydroxychloroquine. These individuals had even lower viral loads at the end of the study compared to those who only got hydroxychloroquine. This research group later released another article looking more into hydroxychloroquine and azithromycin in a study of 80 people (including the 6 above). They noted that 93% had cleared the virus after 8 days. Because this study did not have a control group, it is unclear whether people who did not receive these medications would have seen similar results. Research with more people is needed to help us understand whether improvements were because of the combination of medications or other factors.  CAN I PURCHASE CANNABIS OIL CARTRIDGES? Vaccines & Drugs: The Way Forward for Covid-19 5 Important Factors To Note About The Corona Virus More information on safety is also important because taking azithromycin and hydroxychloroquine together can increase the risk of serious side effects, particularly irregular heart rhythm. Study 3 – March 31, 2020 A small, randomized study of 62 people in Wuhan, China looked at how well hydroxychloroquine worked for hospitalized patients with mild COVID-19. Cough and fever improved about 1 day earlier for those who got 400 mg of hydroxychloroquine for 5 days compared to those who did not get any. Additionally, pneumonia improved in 25 of 31 patients who received hydroxychloroquine (compared to 17 of 31 in the group who didn’t). Studies with negative results for hydroxychloroquine and chloroquine in COVID-19 Study 4 – March 24, 2020 In a small Shanghai study of 30 people with COVID-19, half got 400 mg of hydroxychloroquine for 5 days while the other half did not. At the end of the study, 13 people (87%) who received hydroxychloroquine tested negative for COVID-19 compared to 14 people (93%) who also tested negative but did not receive the medication. This suggests that hydroxychloroquine did not make a difference in recovery. Study 5 – March 30, 2020 Another small study in France wanted to verify the results of Study 2 above, so they gave 11 people the same combination of hydroxychloroquine and azithromycin. After 6 days, 8 of 10 patients were still positive for SARS-CoV-2 (1 person could not be tested due to death). In addition to the death, two people were transferred to the ICU and one had to stop treatment due to side effects. This study was short and, like another study above, did not have a control group to compare patients to. Study 6 – April 14, 2020 In a study of patients hospitalized with COVID-19, 150 people were randomly assigned to either receive high doses of hydroxychloroquine (1,200 mg for 3 days, then 800 mg for 2-3 weeks) or not. At the end of the study, 85% of the patients who got hydroxychloroquine tested negative for the novel coronavirus compared to 81% who did not get the medication. The typical time it took for people to clear the virus and see improvements in symptoms was also similar between groups. About 30% reported side effects, though they were mostly mild. Study 7 – April 21, 2020 A retrospective study looked at veterans affairs (VA) hospitals across the U.S. and identified 368 male veterans who were hospitalized with COVID-19. The veterans were grouped based on whether they had received (1) hydroxychloroquine, (2) hydroxychloroquine and azithromycin, or (3) no hydroxychloroquine.  Death rates were highest in the group that received hydroxychloroquine alone (28%), followed by the group that received hydroxychloroquine and azithromycin (22%). The group that did not receive hydroxychloroquine had the lowest death rate (11%). 

One thing to note is that people who had more severe symptoms, which might partially explain the higher death rates, were also more likely to get medications. People in this study were over 65 years old (on average) and male, which makes it difficult to apply the results to everyone. Study 8 – May 7, 2020 In a large observational study of 1,376 hospitalized patients with COVID-19 in New York City, 811 people (59%) received hydroxychloroquine. There was minimal difference in the risk of needing a breathing tube (intubation) or death between those who didn’t get hydroxychloroquine and those who did. Because this study was observational (meaning the researchers only looked at the end results and were not involved with treatment), it is possible that other factors (confounders) may have affected the findings. Regardless, the researchers concluded that their study does not support the use of hydroxychloroquine for COVID-19. Study 9 – May 11, 2020 Another large observational study of 1,438 hospitalized patients with COVID-19 in New York state also did not see a difference in death rates between those who got hydroxychloroquine (with or without azithromycin) compared to those who did not. Again, because this was an observational study, other factors that were not measured could have also affected the results. Overall, hydroxychloroquine did not show a benefit in this study.

Are hydroxychloroquine and chloroquine safe?

Hydroxychloroquine and chloroquine are generally considered safe when taken for conditions that they have been approved for. If you currently take either of these for malaria or autoimmune conditions, you should continue taking them according to your doctor’s instructions. As with any medications, there are risks and benefits. Both hydroxychloroquine and chloroquine can cause side effects, but in these cases, the benefits outweigh the risk. 5 Important Factors To Note About The Corona Virus Where can I Order HASH Online? Vaccines & Drugs: The Way Forward for Covid-19 On April 24, 2020, the FDA issued a warning stating that using hydroxychloroquine or chloroquine for COVID-19 outside of a hospital setting can put people at risk of serious heart rhythm problems, particularly QT prolongation. This is a well-known side effect of these medications. Because there is still a lot we don’t know about COVID-19, it is unclear if COVID-19 itself increases this risk. Some hospitals in France, Brazil, and Sweden have had to stop using hydroxychloroquine and chloroquine for some coronavirus patients due to severe side effects. Taking hydroxychloroquine or chloroquine with other medications, like azithromycin, that can also cause QT prolongation, can further increase this risk. Prior to the FDA’s warning, several cardiology groups, including the American Heart Association, had issued a joint statement cautioning about the risks of taking these medications together.

Can hydroxychloroquine or chloroquine prevent or cure COVID-19?

At the time of this writing, hydroxychloroquine and chloroquine are not FDA-approved for the prevention or treatment of COVID-19. Additional data is needed to better understand the efficacy and safety of hydroxychloroquine and chloroquine for COVID-19. This is particularly important because current reports are based on a small number of patients, some who received dosages that were typically higher than what has been approved for other conditions. Hydroxychloroquine and chloroquine have not yet been shown to prevent COVID-19 either in a community or hospital setting. In the studies cited above, patients received these medications in the hospital only after they were confirmed to have COVID-19. Additionally, the FDA’s Emergency Use Authorization for hydroxychloroquine and chloroquine are only for hospitalized patients who are unable to participate in a clinical trial. Many clinical studies are currently underway to find a treatment for COVID-19, and the FDA is working with various government agencies, academic centers, and biopharmaceutical companies to expedite the process.

How can I get hydroxychloroquine or chloroquine?

Hydroxychloroquine and chloroquine both require a prescription from your doctor. Due to the recent increase in demand as a result of the COVID-19 pandemic, both medications are currently in short supply. This has made it difficult for patients with rheumatoid arthritis or lupus to get hydroxychloroquine, putting them at increased risk of complications. Many states have restricted pharmacists from dispensing certain medications unless it is specifically being prescribed for an FDA-approved use. Additionally, the American Medical Association, American Pharmacists Association, and American Society of Health-System Pharmacists issued a joint statement discouraging doctors and pharmacists from inappropriately prescribing medications such as hydroxychloroquine and chloroquine. This is to help prevent medication stockpiling and potential drug shortages.

What other medications are currently being used to treat COVID-19?

Researchers are studying many medications as potential treatments for COVID-19. Remdesivir, an investigational antiviral medication given via intravenous (IV) infusion, is one of these. Doctors are trying this medication on critically unwell patients in clinical trials across U.S. hospitals. It is also available through a compassionate use program for patients who do not qualify for the clinical trials. Access to remdesivir is temporarily paused due to overwhelming demand. CAN I PURCHASE CANNABIS OIL CARTRIDGES? Vaccines & Drugs: The Way Forward for Covid-19 HOW TO ORDER HERBAL & LIQUID INCENSE? Where can I Order HASH Online? SHOP CHLOROQUINE NOW 5 Important Factors To Note About The Corona Virus Read the full article

[weedforsaleonlineusa]

5 Important Things To Know About The COVID-19 Outbreak

Strict precautions could save lives as the disease spreads COVID-19 has been changing daily life in the United States as SARS-CoV-2, the virus spreading the disease, has swept across the country, forcing activities to be cancelled and schools and businesses to close. The U.S. declared a national emergency in mid-March, and Americans have been adjusting to strict guidelines and mandates to stay home, wear face masks when they do go out, and stay 6 feet away from other people. Now experts are debating when and how the country can begin to safely reopen. In early March, the World Health Organization (WHO) declared COVID-19 a pandemic—a disease outbreak occurring over a wide geographic area and affecting an exceptionally high proportion of the population. According to the WHO, there are more than 4.3 million confirmed cases of people with COVID-19  and over 295,000 people have died from the disease—a death toll that has far surpassed that of the severe acute respiratory syndrome (SARS) epidemic that occurred in 2002 and 2003. (While some news sources report different numbers, the WHO provides official counts of confirmed cases once a day.) SHOP CHLOROQUINE NOW Vaccines & Drugs: The Way Forward for Covid-19 Can Chloroquine & Hydroxychloroquine Cure Corona Virus? The U.S. currently has the highest number of cases of any country in the world. While some pockets of the U.S., including New York, are now reporting a decrease in new cases, the overall numbers continue to rise. The Centers for Disease Control and Prevention (CDC) currently provides a rough picture of the outbreak in the U.S. here, currently putting the total confirmed and probable cases at more than 1.3 million, and estimating more than 83,000 deaths. If there any discrepancies, data provided by state public health departments should be considered the most up to date, according to the agency.  SARS-CoV-2 is a virus that scientists haven’t seen before. Like other viruses, it is believed to have started in animals and spread to humans. Animal-to-person spread was suspected after the initial outbreak in December among people who had a link to a large seafood and live animal market in Wuhan, China.  Scientists and public health officials are working as quickly as possible to find answers to key questions about how the disease is transmitted and why some cases are more severe than others, while they investigate treatments and a potential vaccine. Below is a list of five things you should know about the coronavirus outbreak.

1. What we know about COVID-19 is changing rapidly

What we do know about coronaviruses is that they cause respiratory tract illnesses that range from the common cold to such potentially deadly illnesses as SARS, which killed almost 800 people. COVID-19 is the first pandemic known to be caused by the emergence of a new coronavirus—novel influenza viruses caused four pandemics in the last century (which is why the response to the new disease is being adapted from existing guidance developed in anticipation of an influenza pandemic).  According to the CDC, reported COVID-19 illnesses have ranged from mild (with no reported symptoms in some cases) to severe, including illness resulting in death. People ages 65 and older, those living in a nursing home or long-term care facility, and people of all ages with underlying health conditions seem to be at higher risk of developing serious illness. But doctors are still working to develop a complete clinical picture of COVID-19, as evidenced by a CDC report noting that 20% of those who have been hospitalized for the disease in the U.S. are younger adults (between 20 and 44 years old). Can Chloroquine & Hydroxychloroquine Cure Corona Virus? Where can I Order HASH Online? Vaccines & Drugs: The Way Forward for Covid-19 “I think there are two main questions,” says Richard Martinello, MD, a Yale Medicine infectious diseases specialist and medical director of infection prevention at Yale New Haven Health. “First, we need to know how this virus is transmitted between people so we can be more precise in our efforts to stop its spread. Data is needed not only to better understand when those who become ill shed the virus, but also which body fluids contain the virus and how those may contaminate surfaces and even the air surrounding them,” says Dr. Martinello. “Second, there needs to be a better understanding of the pathogenesis of the infection and resulting inflammatory response, so that knowledge can drive the development of therapeutic and preventive medications.” More information is becoming available. A letter to the editor published in The New England Journal of Medicine in mid-March showed the virus that causes COVID-19 may be stable for several hours in aerosols (in this case, droplets from an infected person dispersed in air or gas) and for several hours to days on surfaces. Scientists who participated in the analysis found SARS-CoV-2 was detectable in aerosols for up to three hours, copper up to four hours, cardboard up to 24 hours, and plastic and stainless steel up to two to three days. While there is much to learn, scientists involved in the analysis observed that emerging evidence suggests people who are infected might be spreading the virus without recognizing, or prior to recognizing, symptoms, according to the National Institutes of Health (NIH). But Yale Medicine Infectious Diseases specialist Jaimie Meyer, MD, MS, notes, “A lot of times people will make basic science observations in the research lab, but it takes time for us to figure out how clinically relevant it is. So, we don’t know yet know what this study means for transmissibility. Until we understand more about the granular details of how SARS-CoV-2 passes from person to person, public health dictates that people maintain social distancing, wash hands, and frequently disinfect high-touch surfaces."

2. Strict measures are critical for slowing the disease

While we still don't know how the situation will progress around COVID-19, studies of influenza have shown that pandemics begin with an “investigation” phase, followed by “recognition,” “initiation,” and “acceleration” phases, according to the CDC, and that is followed by deceleration, during which there is a decrease in illnesses. Finally, there is a "preparation" phase, where the pandemic has subsided, and public health officials monitor virus activity and prepare for possible additional waves of infection. Different parts of the country can be in different phases of the pandemic, and the length of each phase can vary depending, in part, on the public health response. The U.S. is currently in an acceleration phase, when the peak of illnesses occurs, and efforts are aimed at “flattening the curve.” If you map the number of COVID-19 cases over time, the expectation is that it will peak at some point—on a graph this peak would mirror a surge in patients (which could overwhelm hospitals and health care providers). Flattening the curve would mean there would be fewer patients during that period, and hospitals would be better able to manage the demands of patients who are sick with COVID-19 and other illnesses. White House Guidelines for Opening Up America Again, a phased approach to help state and local officials reopen their economies, provides advice on continuing handwashing, wearing face masks, and taking other precautions even when that happens. Some state leaders have taken steps toward reopening. Connecticut, which plans to start a phased reopening on May 20, is currently keeping safety measures in place at least until that date. This includes requiring nonessential workers to work from home, prohibiting gatherings of more than five people, limiting restaurants to take-out service only, and directing people to wear face coverings in public when a six-foot distance is unavoidable, including in the workplace.

Meanwhile, top health officials have stressed the need for critical testing capacity and the implementation of methods for tracing contacts of people who are infected to protect people and prevent a resurgence of cases when the economy does reopen.

3. Infection prevention is key

There are many things you can do to protect yourself and the people you interact with. As with a cold, a flu vaccine won’t protect people from developing COVID-19.  “The best thing you can do at this point is take care of yourself the way you would to prevent yourself from getting the flu,” says Yale Medicine infectious diseases specialist Joseph Vinetz, MD. “You know you can get the flu when people sneeze and cough on you, or when you touch a doorknob. Washing hands—especially before eating and touching your face, and after going to the bathroom—and avoiding other people who have flu-like symptoms are the best strategies at this point.” HOW TO ORDER HERBAL & LIQUID INCENSE? Can Chloroquine & Hydroxychloroquine Cure Corona Virus? Vaccines & Drugs: The Way Forward for Covid-19 The CDC also recommends the following preventive actions: Wash hands with soap and water for at least 20 seconds. Dry them thoroughly with an air dryer or clean towel. If soap isn’t available, use a hand sanitizer with at least 60% alcohol.Stay home if you’re sick.Avoid touching nose, eyes, and mouth. Use a tissue to cover a cough or sneeze, then dispose of it in the trash.Use a household wipe or spray to disinfect doorknobs, light switches, desks, keyboards, sinks, toilets, cell phones, and other objects and surfaces that are frequently touched.Create a household plan of action in case someone in your house gets sick with COVID-19. You should talk with people who need to be included in your plan, plan ways to care for those who might be at greater risk for serious complications, get to know your neighbors, and make sure you and your family have a plan for caring for a sick person. This includes planning a way to separate a family member who gets sick from those who are healthy, if the need arises. Some cities and states in the U.S. are requiring residents to wear masks in certain public places, like grocery stories and pharmacies. The CDC recommends that everyone voluntarily wear cloth face masks in public settings where other social distancing measures are difficult to maintain, especially in areas where there is significant community-based transmission. A cloth mask is not meant to protect the wearer from infection, but to slow the spread of the virus (if people who have the virus and do not know it wear masks, they may be less likely to transmit it to others). The CDC advises making face coverings at home from simple materials, and reserving surgical masks and N95 respirators for health care workers and other medical first responders. While everyone should take precautions, measures may be critical for adults over 65 years old (the risk seems to gradually increase with age starting at age 40, according to the WHO), people who live in nursing homes, and people of all ages with chronic conditions (such as diabetes, heart disease, and lung disease). People in these categories especially should stock up on household items, groceries, medications, and other supplies in case they need to stay home for an extended period.  

4. Experts are working rapidly to find solutions

In the U.S., widely available testing will be important in understanding how the disease is transmitted and the true infection and mortality rates. There are two kinds of tests: viral tests help diagnose a current infection and antibody tests can tell if you’ve had a previous one (it is not yet known whether COVID-19 antibodies can protect from being infected again or how long protection might last). Health care providers and state and local health departments make determinations about who should be tested. There is an increasing number of tests available, although it may still be difficult to find a place to get tested. Until there is comprehensive testing for COVID-19, it's difficult to know how many cases have not been identified.  CAN I PURCHASE CANNABIS OIL CARTRIDGES? Vaccines & Drugs: The Way Forward for Covid-19 Can Chloroquine & Hydroxychloroquine Cure Corona Virus? One recent development is the first in-home test for the coronavirus. The nasal swab kit, approved by the Food and Drug Administration (FDA) in mid-April, will be made available to health care and emergency workers who may have been exposed or have symptoms of the virus before it is released to the public at a later date. Meanwhile, scientists are studying the virus closely. “With the new virus in a culture dish, they are looking at the biology and working to make drugs to treat it,” says Dr. Vinetz. There is also a great deal of effort underway to assess drugs in development (and some medications currently available) to determine if they are beneficial for treating patients infected with COVID-19, adds Dr. Martinello. While no pharmaceutical products have yet been shown to be safe and effective for COVID-19, a number of existing medicines have been suggested as potential investigational therapies. In early May, the FDA issued an emergency use authorization for the investigational antiviral drug remdesivir to treat suspected or laboratory-confirmed COVID-19 in adults and children hospitalized with severe disease. There is still limited information about the safety and effectiveness of remdesivir when used for COVID-19, but preliminary studies have shown that it can shorten the time to recovery in some patients. Remdesivir is an antiviral treatment that  was previously tested in humans with Ebola virus disease and has shown promise in animal models for treating SARS and Middle Eastern Respiratory Syndrome (MERS), a deadly virus that was first reported in Saudi Arabia in 2012.

5. If you feel ill, here's what you should do

So far, information shows the severity of COVID-19 infection ranges from very mild (sometimes with no reported symptoms at all) to severe to the point of requiring hospitalization. The CDC recently expanded its list of possible symptoms of COVID-19 The symptoms can appear anywhere between 2 to 14 days after exposure, and may include:  FeverCoughShortness of breath and difficulty breathing ChillsRepeated shaking with chillsMuscle painHeadacheSore throatNew loss of taste or smell You should call your medical provider for advice if you experience these symptoms, especially if you have been in close contact with a person known to have COVID-19 or live in an area with ongoing spread of the disease. The CDC has a Coronavirus Self-Checker that may help you determine whether you should seek help. Most people will have a mild illness and can recover at home without medical care. Seek medical attention immediately if you are at home and experience emergency warning signs, including difficulty breathing, persistent pain or pressure in the chest, new confusion or ability to arouse, or bluish lips or face. This list is not inclusive, so consult your medical provider if you notice other concerning symptoms. 

Be aware of the information and resources that are available to you

Because knowledge about the new virus is evolving rapidly, you can expect information and recommendations to change frequently. Threats like COVID-19 can lead to the circulation of misinformation, so it’s important to trust information only from reputable health organizations and government sources such as the CDC and the WHO. “The public health infrastructure in the U.S. is a critical resource for leading the federal, state, and local response,” Dr. Martinello says. Can Chloroquine & Hydroxychloroquine Cure Corona Virus? CAN I PURCHASE CANNABIS OIL CARTRIDGES? Vaccines & Drugs: The Way Forward for Covid-19 HOW TO ORDER HERBAL & LIQUID INCENSE? Where can I Order HASH Online? SHOP CHLOROQUINE NOW Read the full article

[weedforsaleonlineusa]

5 Important Things To Know About The COVID-19 Outbreak

Strict precautions could save lives as the disease spreads COVID-19 has been changing daily life in the United States as SARS-CoV-2, the virus spreading the disease, has swept across the country, forcing activities to be cancelled and schools and businesses to close. The U.S. declared a national emergency in mid-March, and Americans have been adjusting to strict guidelines and mandates to stay home, wear face masks when they do go out, and stay 6 feet away from other people. Now experts are debating when and how the country can begin to safely reopen. In early March, the World Health Organization (WHO) declared COVID-19 a pandemic—a disease outbreak occurring over a wide geographic area and affecting an exceptionally high proportion of the population. According to the WHO, there are more than 4.3 million confirmed cases of people with COVID-19  and over 295,000 people have died from the disease—a death toll that has far surpassed that of the severe acute respiratory syndrome (SARS) epidemic that occurred in 2002 and 2003. (While some news sources report different numbers, the WHO provides official counts of confirmed cases once a day.) SHOP CHLOROQUINE NOW Vaccines & Drugs: The Way Forward for Covid-19 Can Chloroquine & Hydroxychloroquine Cure Corona Virus? The U.S. currently has the highest number of cases of any country in the world. While some pockets of the U.S., including New York, are now reporting a decrease in new cases, the overall numbers continue to rise. The Centers for Disease Control and Prevention (CDC) currently provides a rough picture of the outbreak in the U.S. here, currently putting the total confirmed and probable cases at more than 1.3 million, and estimating more than 83,000 deaths. If there any discrepancies, data provided by state public health departments should be considered the most up to date, according to the agency.  SARS-CoV-2 is a virus that scientists haven’t seen before. Like other viruses, it is believed to have started in animals and spread to humans. Animal-to-person spread was suspected after the initial outbreak in December among people who had a link to a large seafood and live animal market in Wuhan, China.  Scientists and public health officials are working as quickly as possible to find answers to key questions about how the disease is transmitted and why some cases are more severe than others, while they investigate treatments and a potential vaccine. Below is a list of five things you should know about the coronavirus outbreak.

1. What we know about COVID-19 is changing rapidly

What we do know about coronaviruses is that they cause respiratory tract illnesses that range from the common cold to such potentially deadly illnesses as SARS, which killed almost 800 people. COVID-19 is the first pandemic known to be caused by the emergence of a new coronavirus—novel influenza viruses caused four pandemics in the last century (which is why the response to the new disease is being adapted from existing guidance developed in anticipation of an influenza pandemic).  According to the CDC, reported COVID-19 illnesses have ranged from mild (with no reported symptoms in some cases) to severe, including illness resulting in death. People ages 65 and older, those living in a nursing home or long-term care facility, and people of all ages with underlying health conditions seem to be at higher risk of developing serious illness. But doctors are still working to develop a complete clinical picture of COVID-19, as evidenced by a CDC report noting that 20% of those who have been hospitalized for the disease in the U.S. are younger adults (between 20 and 44 years old). Can Chloroquine & Hydroxychloroquine Cure Corona Virus? Where can I Order HASH Online? Vaccines & Drugs: The Way Forward for Covid-19 “I think there are two main questions,” says Richard Martinello, MD, a Yale Medicine infectious diseases specialist and medical director of infection prevention at Yale New Haven Health. “First, we need to know how this virus is transmitted between people so we can be more precise in our efforts to stop its spread. Data is needed not only to better understand when those who become ill shed the virus, but also which body fluids contain the virus and how those may contaminate surfaces and even the air surrounding them,” says Dr. Martinello. “Second, there needs to be a better understanding of the pathogenesis of the infection and resulting inflammatory response, so that knowledge can drive the development of therapeutic and preventive medications.” More information is becoming available. A letter to the editor published in The New England Journal of Medicine in mid-March showed the virus that causes COVID-19 may be stable for several hours in aerosols (in this case, droplets from an infected person dispersed in air or gas) and for several hours to days on surfaces. Scientists who participated in the analysis found SARS-CoV-2 was detectable in aerosols for up to three hours, copper up to four hours, cardboard up to 24 hours, and plastic and stainless steel up to two to three days. While there is much to learn, scientists involved in the analysis observed that emerging evidence suggests people who are infected might be spreading the virus without recognizing, or prior to recognizing, symptoms, according to the National Institutes of Health (NIH). But Yale Medicine Infectious Diseases specialist Jaimie Meyer, MD, MS, notes, “A lot of times people will make basic science observations in the research lab, but it takes time for us to figure out how clinically relevant it is. So, we don’t know yet know what this study means for transmissibility. Until we understand more about the granular details of how SARS-CoV-2 passes from person to person, public health dictates that people maintain social distancing, wash hands, and frequently disinfect high-touch surfaces."

2. Strict measures are critical for slowing the disease

While we still don't know how the situation will progress around COVID-19, studies of influenza have shown that pandemics begin with an “investigation” phase, followed by “recognition,” “initiation,” and “acceleration” phases, according to the CDC, and that is followed by deceleration, during which there is a decrease in illnesses. Finally, there is a "preparation" phase, where the pandemic has subsided, and public health officials monitor virus activity and prepare for possible additional waves of infection. Different parts of the country can be in different phases of the pandemic, and the length of each phase can vary depending, in part, on the public health response. The U.S. is currently in an acceleration phase, when the peak of illnesses occurs, and efforts are aimed at “flattening the curve.” If you map the number of COVID-19 cases over time, the expectation is that it will peak at some point—on a graph this peak would mirror a surge in patients (which could overwhelm hospitals and health care providers). Flattening the curve would mean there would be fewer patients during that period, and hospitals would be better able to manage the demands of patients who are sick with COVID-19 and other illnesses. White House Guidelines for Opening Up America Again, a phased approach to help state and local officials reopen their economies, provides advice on continuing handwashing, wearing face masks, and taking other precautions even when that happens. Some state leaders have taken steps toward reopening. Connecticut, which plans to start a phased reopening on May 20, is currently keeping safety measures in place at least until that date. This includes requiring nonessential workers to work from home, prohibiting gatherings of more than five people, limiting restaurants to take-out service only, and directing people to wear face coverings in public when a six-foot distance is unavoidable, including in the workplace.

Meanwhile, top health officials have stressed the need for critical testing capacity and the implementation of methods for tracing contacts of people who are infected to protect people and prevent a resurgence of cases when the economy does reopen.

3. Infection prevention is key

There are many things you can do to protect yourself and the people you interact with. As with a cold, a flu vaccine won’t protect people from developing COVID-19.  “The best thing you can do at this point is take care of yourself the way you would to prevent yourself from getting the flu,” says Yale Medicine infectious diseases specialist Joseph Vinetz, MD. “You know you can get the flu when people sneeze and cough on you, or when you touch a doorknob. Washing hands—especially before eating and touching your face, and after going to the bathroom—and avoiding other people who have flu-like symptoms are the best strategies at this point.” HOW TO ORDER HERBAL & LIQUID INCENSE? Can Chloroquine & Hydroxychloroquine Cure Corona Virus? Vaccines & Drugs: The Way Forward for Covid-19 The CDC also recommends the following preventive actions: Wash hands with soap and water for at least 20 seconds. Dry them thoroughly with an air dryer or clean towel. If soap isn’t available, use a hand sanitizer with at least 60% alcohol.Stay home if you’re sick.Avoid touching nose, eyes, and mouth. Use a tissue to cover a cough or sneeze, then dispose of it in the trash.Use a household wipe or spray to disinfect doorknobs, light switches, desks, keyboards, sinks, toilets, cell phones, and other objects and surfaces that are frequently touched.Create a household plan of action in case someone in your house gets sick with COVID-19. You should talk with people who need to be included in your plan, plan ways to care for those who might be at greater risk for serious complications, get to know your neighbors, and make sure you and your family have a plan for caring for a sick person. This includes planning a way to separate a family member who gets sick from those who are healthy, if the need arises. Some cities and states in the U.S. are requiring residents to wear masks in certain public places, like grocery stories and pharmacies. The CDC recommends that everyone voluntarily wear cloth face masks in public settings where other social distancing measures are difficult to maintain, especially in areas where there is significant community-based transmission. A cloth mask is not meant to protect the wearer from infection, but to slow the spread of the virus (if people who have the virus and do not know it wear masks, they may be less likely to transmit it to others). The CDC advises making face coverings at home from simple materials, and reserving surgical masks and N95 respirators for health care workers and other medical first responders. While everyone should take precautions, measures may be critical for adults over 65 years old (the risk seems to gradually increase with age starting at age 40, according to the WHO), people who live in nursing homes, and people of all ages with chronic conditions (such as diabetes, heart disease, and lung disease). People in these categories especially should stock up on household items, groceries, medications, and other supplies in case they need to stay home for an extended period.  

4. Experts are working rapidly to find solutions

In the U.S., widely available testing will be important in understanding how the disease is transmitted and the true infection and mortality rates. There are two kinds of tests: viral tests help diagnose a current infection and antibody tests can tell if you’ve had a previous one (it is not yet known whether COVID-19 antibodies can protect from being infected again or how long protection might last). Health care providers and state and local health departments make determinations about who should be tested. There is an increasing number of tests available, although it may still be difficult to find a place to get tested. Until there is comprehensive testing for COVID-19, it's difficult to know how many cases have not been identified.  CAN I PURCHASE CANNABIS OIL CARTRIDGES? Vaccines & Drugs: The Way Forward for Covid-19 Can Chloroquine & Hydroxychloroquine Cure Corona Virus? One recent development is the first in-home test for the coronavirus. The nasal swab kit, approved by the Food and Drug Administration (FDA) in mid-April, will be made available to health care and emergency workers who may have been exposed or have symptoms of the virus before it is released to the public at a later date. Meanwhile, scientists are studying the virus closely. “With the new virus in a culture dish, they are looking at the biology and working to make drugs to treat it,” says Dr. Vinetz. There is also a great deal of effort underway to assess drugs in development (and some medications currently available) to determine if they are beneficial for treating patients infected with COVID-19, adds Dr. Martinello. While no pharmaceutical products have yet been shown to be safe and effective for COVID-19, a number of existing medicines have been suggested as potential investigational therapies. In early May, the FDA issued an emergency use authorization for the investigational antiviral drug remdesivir to treat suspected or laboratory-confirmed COVID-19 in adults and children hospitalized with severe disease. There is still limited information about the safety and effectiveness of remdesivir when used for COVID-19, but preliminary studies have shown that it can shorten the time to recovery in some patients. Remdesivir is an antiviral treatment that  was previously tested in humans with Ebola virus disease and has shown promise in animal models for treating SARS and Middle Eastern Respiratory Syndrome (MERS), a deadly virus that was first reported in Saudi Arabia in 2012.

5. If you feel ill, here's what you should do

So far, information shows the severity of COVID-19 infection ranges from very mild (sometimes with no reported symptoms at all) to severe to the point of requiring hospitalization. The CDC recently expanded its list of possible symptoms of COVID-19 The symptoms can appear anywhere between 2 to 14 days after exposure, and may include:  FeverCoughShortness of breath and difficulty breathing ChillsRepeated shaking with chillsMuscle painHeadacheSore throatNew loss of taste or smell You should call your medical provider for advice if you experience these symptoms, especially if you have been in close contact with a person known to have COVID-19 or live in an area with ongoing spread of the disease. The CDC has a Coronavirus Self-Checker that may help you determine whether you should seek help. Most people will have a mild illness and can recover at home without medical care. Seek medical attention immediately if you are at home and experience emergency warning signs, including difficulty breathing, persistent pain or pressure in the chest, new confusion or ability to arouse, or bluish lips or face. This list is not inclusive, so consult your medical provider if you notice other concerning symptoms. 

Be aware of the information and resources that are available to you

Because knowledge about the new virus is evolving rapidly, you can expect information and recommendations to change frequently. Threats like COVID-19 can lead to the circulation of misinformation, so it’s important to trust information only from reputable health organizations and government sources such as the CDC and the WHO. “The public health infrastructure in the U.S. is a critical resource for leading the federal, state, and local response,” Dr. Martinello says. Can Chloroquine & Hydroxychloroquine Cure Corona Virus? CAN I PURCHASE CANNABIS OIL CARTRIDGES? Vaccines & Drugs: The Way Forward for Covid-19 HOW TO ORDER HERBAL & LIQUID INCENSE? Where can I Order HASH Online? SHOP CHLOROQUINE NOW Read the full article

[weedforsaleonlineusa]

How Far Can Chloroquine & Hydroxychloroquine Cure Corona Virus?

Key takeaways: Hydroxychloroquine and chloroquine are two medications that have been used for many decades to treat malaria and autoimmune conditions like rheumatoid arthritis and lupus.There is not enough medical data at this time to prove that hydroxychloroquine and chloroquine work for COVID-19 — while some small studies suggest the medications may be helpful, other studies saw no benefit.There have been no studies showing that these medications work for prevention, and the FDA has issued a warning for serious heart-related side effects if hydroxychloroquine or chloroquine are taken outside of a hospital setting for COVID-19.There’s now a shortage of hydroxychloroquine and chloroquine, which means that people who normally take these medications to manage their health are having a harder time getting the treatment they need. Hydroxychloroquine (Plaquenil) and chloroquine are two medications that have recently been making headlines as possible treatments for the coronavirus disease (COVID-19). Do these medications actually work against COVID-19? Here’s what we know.

What is hydroxychloroquine, and what is chloroquine?

Hydroxychloroquine is a medication first approved to treat malaria, an infection caused by a parasite. It is similar in structure to chloroquine, which was first approved by the FDA in 1949.  SHOP CHLOROQUINE NOW Vaccines & Drugs: The Way Forward for Covid-19 5 Important Factors To Note About The Corona Virus Hydroxychloroquine, approved in 1955, is typically preferred over chloroquine because it has fewer side effects. Side effects for both medications, which are more common at higher doses and with long-term use, include: Irreversible visual changesLong QT or QT prolongation (abnormal heart rhythm)Muscle weakness or nerve painHypoglycemia (low blood glucose)Worsening of psoriasis

What do hydroxychloroquine or chloroquine usually treat?

Hydroxychloroquine and chloroquine were first used to prevent or treat malaria. Both are available as pills that are taken by mouth. Hydroxychloroquine is also approved for long-term use in rheumatoid arthritis and lupus.

The dosage varies depending on what the medications are being used for. On the low end, hydroxychloroquine is taken as 400 mg orally once a week for malaria prevention and should be continued for 4 weeks after leaving an endemic area. On the high end, hydroxychloroquine is taken as 200 mg to 400 mg daily for rheumatoid arthritis.

Why are hydroxychloroquine and chloroquine being mentioned with COVID-19?

Recent in vitro studies (studies done in a petri dish or test tube rather than in animals or humans) have shown that both hydroxychloroquine and chloroquine have antiviral properties against SARS-CoV-2, the virus that causes COVID-19. In these studies, these medications worked by interfering with the chemical environment of human cell membranes. This blocked the virus from entering and multiplying inside the cells. A medication working in vitro does not always mean that it will work once inside a human body. Nonetheless, based on these early findings, hospitals worldwide have begun using hydroxychloroquine and chloroquine for patients with COVID-19. On March 28, 2020, the FDA issued an Emergency Use Authorization (EUA) that allows providers to request a supply of hydroxychloroquine or chloroquine for hospitalized patients with COVID-19 who are unable to join a clinical trial. The EUA does not mean that the FDA has approved these medications for the treatment of COVID-19. The intent of the EUA is to help increase access to these medications by allowing doctors to request a supply from the Strategic National Stockpile for these specific cases.

What do research studies say about hydroxychloroquine, chloroquine, and COVID-19?

Data is still extremely limited. We need more research to determine the best dose, when to give it and for how long, and how the risks and benefits of these medications stack up in the fight against COVID-19. Large, randomized, controlled trials (the gold standard for clinical trials) are needed to confirm many of the findings summarized below. HOW TO ORDER HERBAL & LIQUID INCENSE? Vaccines & Drugs: The Way Forward for Covid-19 5 Important Factors To Note About The Corona Virus Several studies have gained a lot of attention in recent media reports. We break it down between those that suggest the medications work compared to those that did not see a benefit. (Please note that even though results are being shared, few have been accepted into peer-reviewed medical journals.) Studies with positive results for hydroxychloroquine and chloroquine in COVID-19 Study 1 – March 16, 2020 Researchers from China reported in a letter that over 100 people with COVID-19 have been treated with chloroquine. These patients had less severe disease and a shorter illness duration compared to those who did not receive chloroquine. However, results from these studies are not yet available, nor do we have a lot of information about the type of people who received this drug, or what dose they took and for how long. Study 2 – March 20, 2020 A small study in France reported that people who got 600 mg of hydroxychloroquine had a lower amount of the virus (viral load) in the body. The problem with this study is that comparisons were made between patients at different hospitals. This makes it difficult to know if improvements were because of hydroxychloroquine or other things. And, of the 26 people who initially got hydroxychloroquine, 6 people (23%) had to stop treatment because of nausea, worsening disease, leaving the hospital, or death. Six people in this study also received azithromycin (a common antibiotic) with hydroxychloroquine. These individuals had even lower viral loads at the end of the study compared to those who only got hydroxychloroquine. This research group later released another article looking more into hydroxychloroquine and azithromycin in a study of 80 people (including the 6 above). They noted that 93% had cleared the virus after 8 days. Because this study did not have a control group, it is unclear whether people who did not receive these medications would have seen similar results. Research with more people is needed to help us understand whether improvements were because of the combination of medications or other factors.  CAN I PURCHASE CANNABIS OIL CARTRIDGES? Vaccines & Drugs: The Way Forward for Covid-19 5 Important Factors To Note About The Corona Virus More information on safety is also important because taking azithromycin and hydroxychloroquine together can increase the risk of serious side effects, particularly irregular heart rhythm. Study 3 – March 31, 2020 A small, randomized study of 62 people in Wuhan, China looked at how well hydroxychloroquine worked for hospitalized patients with mild COVID-19. Cough and fever improved about 1 day earlier for those who got 400 mg of hydroxychloroquine for 5 days compared to those who did not get any. Additionally, pneumonia improved in 25 of 31 patients who received hydroxychloroquine (compared to 17 of 31 in the group who didn’t). Studies with negative results for hydroxychloroquine and chloroquine in COVID-19 Study 4 – March 24, 2020 In a small Shanghai study of 30 people with COVID-19, half got 400 mg of hydroxychloroquine for 5 days while the other half did not. At the end of the study, 13 people (87%) who received hydroxychloroquine tested negative for COVID-19 compared to 14 people (93%) who also tested negative but did not receive the medication. This suggests that hydroxychloroquine did not make a difference in recovery. Study 5 – March 30, 2020 Another small study in France wanted to verify the results of Study 2 above, so they gave 11 people the same combination of hydroxychloroquine and azithromycin. After 6 days, 8 of 10 patients were still positive for SARS-CoV-2 (1 person could not be tested due to death). In addition to the death, two people were transferred to the ICU and one had to stop treatment due to side effects. This study was short and, like another study above, did not have a control group to compare patients to. Study 6 – April 14, 2020 In a study of patients hospitalized with COVID-19, 150 people were randomly assigned to either receive high doses of hydroxychloroquine (1,200 mg for 3 days, then 800 mg for 2-3 weeks) or not. At the end of the study, 85% of the patients who got hydroxychloroquine tested negative for the novel coronavirus compared to 81% who did not get the medication. The typical time it took for people to clear the virus and see improvements in symptoms was also similar between groups. About 30% reported side effects, though they were mostly mild. Study 7 – April 21, 2020 A retrospective study looked at veterans affairs (VA) hospitals across the U.S. and identified 368 male veterans who were hospitalized with COVID-19. The veterans were grouped based on whether they had received (1) hydroxychloroquine, (2) hydroxychloroquine and azithromycin, or (3) no hydroxychloroquine.  Death rates were highest in the group that received hydroxychloroquine alone (28%), followed by the group that received hydroxychloroquine and azithromycin (22%). The group that did not receive hydroxychloroquine had the lowest death rate (11%). 

One thing to note is that people who had more severe symptoms, which might partially explain the higher death rates, were also more likely to get medications. People in this study were over 65 years old (on average) and male, which makes it difficult to apply the results to everyone. Study 8 – May 7, 2020 In a large observational study of 1,376 hospitalized patients with COVID-19 in New York City, 811 people (59%) received hydroxychloroquine. There was minimal difference in the risk of needing a breathing tube (intubation) or death between those who didn’t get hydroxychloroquine and those who did. Because this study was observational (meaning the researchers only looked at the end results and were not involved with treatment), it is possible that other factors (confounders) may have affected the findings. Regardless, the researchers concluded that their study does not support the use of hydroxychloroquine for COVID-19. Study 9 – May 11, 2020 Another large observational study of 1,438 hospitalized patients with COVID-19 in New York state also did not see a difference in death rates between those who got hydroxychloroquine (with or without azithromycin) compared to those who did not. Again, because this was an observational study, other factors that were not measured could have also affected the results. Overall, hydroxychloroquine did not show a benefit in this study.

Are hydroxychloroquine and chloroquine safe?

Hydroxychloroquine and chloroquine are generally considered safe when taken for conditions that they have been approved for. If you currently take either of these for malaria or autoimmune conditions, you should continue taking them according to your doctor’s instructions. As with any medications, there are risks and benefits. Both hydroxychloroquine and chloroquine can cause side effects, but in these cases, the benefits outweigh the risk. 5 Important Factors To Note About The Corona Virus Where can I Order HASH Online? Vaccines & Drugs: The Way Forward for Covid-19 On April 24, 2020, the FDA issued a warning stating that using hydroxychloroquine or chloroquine for COVID-19 outside of a hospital setting can put people at risk of serious heart rhythm problems, particularly QT prolongation. This is a well-known side effect of these medications. Because there is still a lot we don’t know about COVID-19, it is unclear if COVID-19 itself increases this risk. Some hospitals in France, Brazil, and Sweden have had to stop using hydroxychloroquine and chloroquine for some coronavirus patients due to severe side effects. Taking hydroxychloroquine or chloroquine with other medications, like azithromycin, that can also cause QT prolongation, can further increase this risk. Prior to the FDA’s warning, several cardiology groups, including the American Heart Association, had issued a joint statement cautioning about the risks of taking these medications together.

Can hydroxychloroquine or chloroquine prevent or cure COVID-19?

At the time of this writing, hydroxychloroquine and chloroquine are not FDA-approved for the prevention or treatment of COVID-19. Additional data is needed to better understand the efficacy and safety of hydroxychloroquine and chloroquine for COVID-19. This is particularly important because current reports are based on a small number of patients, some who received dosages that were typically higher than what has been approved for other conditions. Hydroxychloroquine and chloroquine have not yet been shown to prevent COVID-19 either in a community or hospital setting. In the studies cited above, patients received these medications in the hospital only after they were confirmed to have COVID-19. Additionally, the FDA’s Emergency Use Authorization for hydroxychloroquine and chloroquine are only for hospitalized patients who are unable to participate in a clinical trial. Many clinical studies are currently underway to find a treatment for COVID-19, and the FDA is working with various government agencies, academic centers, and biopharmaceutical companies to expedite the process.

How can I get hydroxychloroquine or chloroquine?

Hydroxychloroquine and chloroquine both require a prescription from your doctor. Due to the recent increase in demand as a result of the COVID-19 pandemic, both medications are currently in short supply. This has made it difficult for patients with rheumatoid arthritis or lupus to get hydroxychloroquine, putting them at increased risk of complications. Many states have restricted pharmacists from dispensing certain medications unless it is specifically being prescribed for an FDA-approved use. Additionally, the American Medical Association, American Pharmacists Association, and American Society of Health-System Pharmacists issued a joint statement discouraging doctors and pharmacists from inappropriately prescribing medications such as hydroxychloroquine and chloroquine. This is to help prevent medication stockpiling and potential drug shortages.

What other medications are currently being used to treat COVID-19?

Researchers are studying many medications as potential treatments for COVID-19. Remdesivir, an investigational antiviral medication given via intravenous (IV) infusion, is one of these. Doctors are trying this medication on critically unwell patients in clinical trials across U.S. hospitals. It is also available through a compassionate use program for patients who do not qualify for the clinical trials. Access to remdesivir is temporarily paused due to overwhelming demand. CAN I PURCHASE CANNABIS OIL CARTRIDGES? Vaccines & Drugs: The Way Forward for Covid-19 HOW TO ORDER HERBAL & LIQUID INCENSE? Where can I Order HASH Online? SHOP CHLOROQUINE NOW 5 Important Factors To Note About The Corona Virus Read the full article

[weedforsaleonlineusa]

5 Important Things To Know About The COVID-19 Outbreak

Strict precautions could save lives as the disease spreads COVID-19 has been changing daily life in the United States as SARS-CoV-2, the virus spreading the disease, has swept across the country, forcing activities to be cancelled and schools and businesses to close. The U.S. declared a national emergency in mid-March, and Americans have been adjusting to strict guidelines and mandates to stay home, wear face masks when they do go out, and stay 6 feet away from other people. Now experts are debating when and how the country can begin to safely reopen. In early March, the World Health Organization (WHO) declared COVID-19 a pandemic—a disease outbreak occurring over a wide geographic area and affecting an exceptionally high proportion of the population. According to the WHO, there are more than 4.3 million confirmed cases of people with COVID-19  and over 295,000 people have died from the disease—a death toll that has far surpassed that of the severe acute respiratory syndrome (SARS) epidemic that occurred in 2002 and 2003. (While some news sources report different numbers, the WHO provides official counts of confirmed cases once a day.) SHOP CHLOROQUINE NOW Vaccines & Drugs: The Way Forward for Covid-19 Can Chloroquine & Hydroxychloroquine Cure Corona Virus? The U.S. currently has the highest number of cases of any country in the world. While some pockets of the U.S., including New York, are now reporting a decrease in new cases, the overall numbers continue to rise. The Centers for Disease Control and Prevention (CDC) currently provides a rough picture of the outbreak in the U.S. here, currently putting the total confirmed and probable cases at more than 1.3 million, and estimating more than 83,000 deaths. If there any discrepancies, data provided by state public health departments should be considered the most up to date, according to the agency.  SARS-CoV-2 is a virus that scientists haven’t seen before. Like other viruses, it is believed to have started in animals and spread to humans. Animal-to-person spread was suspected after the initial outbreak in December among people who had a link to a large seafood and live animal market in Wuhan, China.  Scientists and public health officials are working as quickly as possible to find answers to key questions about how the disease is transmitted and why some cases are more severe than others, while they investigate treatments and a potential vaccine. Below is a list of five things you should know about the coronavirus outbreak.

1. What we know about COVID-19 is changing rapidly

What we do know about coronaviruses is that they cause respiratory tract illnesses that range from the common cold to such potentially deadly illnesses as SARS, which killed almost 800 people. COVID-19 is the first pandemic known to be caused by the emergence of a new coronavirus—novel influenza viruses caused four pandemics in the last century (which is why the response to the new disease is being adapted from existing guidance developed in anticipation of an influenza pandemic).  According to the CDC, reported COVID-19 illnesses have ranged from mild (with no reported symptoms in some cases) to severe, including illness resulting in death. People ages 65 and older, those living in a nursing home or long-term care facility, and people of all ages with underlying health conditions seem to be at higher risk of developing serious illness. But doctors are still working to develop a complete clinical picture of COVID-19, as evidenced by a CDC report noting that 20% of those who have been hospitalized for the disease in the U.S. are younger adults (between 20 and 44 years old). Can Chloroquine & Hydroxychloroquine Cure Corona Virus? Where can I Order HASH Online? Vaccines & Drugs: The Way Forward for Covid-19 “I think there are two main questions,” says Richard Martinello, MD, a Yale Medicine infectious diseases specialist and medical director of infection prevention at Yale New Haven Health. “First, we need to know how this virus is transmitted between people so we can be more precise in our efforts to stop its spread. Data is needed not only to better understand when those who become ill shed the virus, but also which body fluids contain the virus and how those may contaminate surfaces and even the air surrounding them,” says Dr. Martinello. “Second, there needs to be a better understanding of the pathogenesis of the infection and resulting inflammatory response, so that knowledge can drive the development of therapeutic and preventive medications.” More information is becoming available. A letter to the editor published in The New England Journal of Medicine in mid-March showed the virus that causes COVID-19 may be stable for several hours in aerosols (in this case, droplets from an infected person dispersed in air or gas) and for several hours to days on surfaces. Scientists who participated in the analysis found SARS-CoV-2 was detectable in aerosols for up to three hours, copper up to four hours, cardboard up to 24 hours, and plastic and stainless steel up to two to three days. While there is much to learn, scientists involved in the analysis observed that emerging evidence suggests people who are infected might be spreading the virus without recognizing, or prior to recognizing, symptoms, according to the National Institutes of Health (NIH). But Yale Medicine Infectious Diseases specialist Jaimie Meyer, MD, MS, notes, “A lot of times people will make basic science observations in the research lab, but it takes time for us to figure out how clinically relevant it is. So, we don’t know yet know what this study means for transmissibility. Until we understand more about the granular details of how SARS-CoV-2 passes from person to person, public health dictates that people maintain social distancing, wash hands, and frequently disinfect high-touch surfaces."

2. Strict measures are critical for slowing the disease

While we still don't know how the situation will progress around COVID-19, studies of influenza have shown that pandemics begin with an “investigation” phase, followed by “recognition,” “initiation,” and “acceleration” phases, according to the CDC, and that is followed by deceleration, during which there is a decrease in illnesses. Finally, there is a "preparation" phase, where the pandemic has subsided, and public health officials monitor virus activity and prepare for possible additional waves of infection. Different parts of the country can be in different phases of the pandemic, and the length of each phase can vary depending, in part, on the public health response. The U.S. is currently in an acceleration phase, when the peak of illnesses occurs, and efforts are aimed at “flattening the curve.” If you map the number of COVID-19 cases over time, the expectation is that it will peak at some point—on a graph this peak would mirror a surge in patients (which could overwhelm hospitals and health care providers). Flattening the curve would mean there would be fewer patients during that period, and hospitals would be better able to manage the demands of patients who are sick with COVID-19 and other illnesses. White House Guidelines for Opening Up America Again, a phased approach to help state and local officials reopen their economies, provides advice on continuing handwashing, wearing face masks, and taking other precautions even when that happens. Some state leaders have taken steps toward reopening. Connecticut, which plans to start a phased reopening on May 20, is currently keeping safety measures in place at least until that date. This includes requiring nonessential workers to work from home, prohibiting gatherings of more than five people, limiting restaurants to take-out service only, and directing people to wear face coverings in public when a six-foot distance is unavoidable, including in the workplace.

Meanwhile, top health officials have stressed the need for critical testing capacity and the implementation of methods for tracing contacts of people who are infected to protect people and prevent a resurgence of cases when the economy does reopen.

3. Infection prevention is key

There are many things you can do to protect yourself and the people you interact with. As with a cold, a flu vaccine won’t protect people from developing COVID-19.  “The best thing you can do at this point is take care of yourself the way you would to prevent yourself from getting the flu,” says Yale Medicine infectious diseases specialist Joseph Vinetz, MD. “You know you can get the flu when people sneeze and cough on you, or when you touch a doorknob. Washing hands—especially before eating and touching your face, and after going to the bathroom—and avoiding other people who have flu-like symptoms are the best strategies at this point.” HOW TO ORDER HERBAL & LIQUID INCENSE? Can Chloroquine & Hydroxychloroquine Cure Corona Virus? Vaccines & Drugs: The Way Forward for Covid-19 The CDC also recommends the following preventive actions: Wash hands with soap and water for at least 20 seconds. Dry them thoroughly with an air dryer or clean towel. If soap isn’t available, use a hand sanitizer with at least 60% alcohol.Stay home if you’re sick.Avoid touching nose, eyes, and mouth. Use a tissue to cover a cough or sneeze, then dispose of it in the trash.Use a household wipe or spray to disinfect doorknobs, light switches, desks, keyboards, sinks, toilets, cell phones, and other objects and surfaces that are frequently touched.Create a household plan of action in case someone in your house gets sick with COVID-19. You should talk with people who need to be included in your plan, plan ways to care for those who might be at greater risk for serious complications, get to know your neighbors, and make sure you and your family have a plan for caring for a sick person. This includes planning a way to separate a family member who gets sick from those who are healthy, if the need arises. Some cities and states in the U.S. are requiring residents to wear masks in certain public places, like grocery stories and pharmacies. The CDC recommends that everyone voluntarily wear cloth face masks in public settings where other social distancing measures are difficult to maintain, especially in areas where there is significant community-based transmission. A cloth mask is not meant to protect the wearer from infection, but to slow the spread of the virus (if people who have the virus and do not know it wear masks, they may be less likely to transmit it to others). The CDC advises making face coverings at home from simple materials, and reserving surgical masks and N95 respirators for health care workers and other medical first responders. While everyone should take precautions, measures may be critical for adults over 65 years old (the risk seems to gradually increase with age starting at age 40, according to the WHO), people who live in nursing homes, and people of all ages with chronic conditions (such as diabetes, heart disease, and lung disease). People in these categories especially should stock up on household items, groceries, medications, and other supplies in case they need to stay home for an extended period.  

4. Experts are working rapidly to find solutions

In the U.S., widely available testing will be important in understanding how the disease is transmitted and the true infection and mortality rates. There are two kinds of tests: viral tests help diagnose a current infection and antibody tests can tell if you’ve had a previous one (it is not yet known whether COVID-19 antibodies can protect from being infected again or how long protection might last). Health care providers and state and local health departments make determinations about who should be tested. There is an increasing number of tests available, although it may still be difficult to find a place to get tested. Until there is comprehensive testing for COVID-19, it's difficult to know how many cases have not been identified.  CAN I PURCHASE CANNABIS OIL CARTRIDGES? Vaccines & Drugs: The Way Forward for Covid-19 Can Chloroquine & Hydroxychloroquine Cure Corona Virus? One recent development is the first in-home test for the coronavirus. The nasal swab kit, approved by the Food and Drug Administration (FDA) in mid-April, will be made available to health care and emergency workers who may have been exposed or have symptoms of the virus before it is released to the public at a later date. Meanwhile, scientists are studying the virus closely. “With the new virus in a culture dish, they are looking at the biology and working to make drugs to treat it,” says Dr. Vinetz. There is also a great deal of effort underway to assess drugs in development (and some medications currently available) to determine if they are beneficial for treating patients infected with COVID-19, adds Dr. Martinello. While no pharmaceutical products have yet been shown to be safe and effective for COVID-19, a number of existing medicines have been suggested as potential investigational therapies. In early May, the FDA issued an emergency use authorization for the investigational antiviral drug remdesivir to treat suspected or laboratory-confirmed COVID-19 in adults and children hospitalized with severe disease. There is still limited information about the safety and effectiveness of remdesivir when used for COVID-19, but preliminary studies have shown that it can shorten the time to recovery in some patients. Remdesivir is an antiviral treatment that  was previously tested in humans with Ebola virus disease and has shown promise in animal models for treating SARS and Middle Eastern Respiratory Syndrome (MERS), a deadly virus that was first reported in Saudi Arabia in 2012.

5. If you feel ill, here's what you should do

So far, information shows the severity of COVID-19 infection ranges from very mild (sometimes with no reported symptoms at all) to severe to the point of requiring hospitalization. The CDC recently expanded its list of possible symptoms of COVID-19 The symptoms can appear anywhere between 2 to 14 days after exposure, and may include:  FeverCoughShortness of breath and difficulty breathing ChillsRepeated shaking with chillsMuscle painHeadacheSore throatNew loss of taste or smell You should call your medical provider for advice if you experience these symptoms, especially if you have been in close contact with a person known to have COVID-19 or live in an area with ongoing spread of the disease. The CDC has a Coronavirus Self-Checker that may help you determine whether you should seek help. Most people will have a mild illness and can recover at home without medical care. Seek medical attention immediately if you are at home and experience emergency warning signs, including difficulty breathing, persistent pain or pressure in the chest, new confusion or ability to arouse, or bluish lips or face. This list is not inclusive, so consult your medical provider if you notice other concerning symptoms. 

Be aware of the information and resources that are available to you

Because knowledge about the new virus is evolving rapidly, you can expect information and recommendations to change frequently. Threats like COVID-19 can lead to the circulation of misinformation, so it’s important to trust information only from reputable health organizations and government sources such as the CDC and the WHO. “The public health infrastructure in the U.S. is a critical resource for leading the federal, state, and local response,” Dr. Martinello says. Can Chloroquine & Hydroxychloroquine Cure Corona Virus? CAN I PURCHASE CANNABIS OIL CARTRIDGES? Vaccines & Drugs: The Way Forward for Covid-19 HOW TO ORDER HERBAL & LIQUID INCENSE? Where can I Order HASH Online? SHOP CHLOROQUINE NOW Read the full article

[weedforsaleonlineusa]

How Far Can Chloroquine & Hydroxychloroquine Cure Corona Virus?

Key takeaways: Hydroxychloroquine and chloroquine are two medications that have been used for many decades to treat malaria and autoimmune conditions like rheumatoid arthritis and lupus.There is not enough medical data at this time to prove that hydroxychloroquine and chloroquine work for COVID-19 — while some small studies suggest the medications may be helpful, other studies saw no benefit.There have been no studies showing that these medications work for prevention, and the FDA has issued a warning for serious heart-related side effects if hydroxychloroquine or chloroquine are taken outside of a hospital setting for COVID-19.There’s now a shortage of hydroxychloroquine and chloroquine, which means that people who normally take these medications to manage their health are having a harder time getting the treatment they need. Hydroxychloroquine (Plaquenil) and chloroquine are two medications that have recently been making headlines as possible treatments for the coronavirus disease (COVID-19). Do these medications actually work against COVID-19? Here’s what we know.

What is hydroxychloroquine, and what is chloroquine?

Hydroxychloroquine is a medication first approved to treat malaria, an infection caused by a parasite. It is similar in structure to chloroquine, which was first approved by the FDA in 1949.  SHOP CHLOROQUINE NOW Vaccines & Drugs: The Way Forward for Covid-19 5 Important Factors To Note About The Corona Virus Hydroxychloroquine, approved in 1955, is typically preferred over chloroquine because it has fewer side effects. Side effects for both medications, which are more common at higher doses and with long-term use, include: Irreversible visual changesLong QT or QT prolongation (abnormal heart rhythm)Muscle weakness or nerve painHypoglycemia (low blood glucose)Worsening of psoriasis

What do hydroxychloroquine or chloroquine usually treat?

Hydroxychloroquine and chloroquine were first used to prevent or treat malaria. Both are available as pills that are taken by mouth. Hydroxychloroquine is also approved for long-term use in rheumatoid arthritis and lupus.

The dosage varies depending on what the medications are being used for. On the low end, hydroxychloroquine is taken as 400 mg orally once a week for malaria prevention and should be continued for 4 weeks after leaving an endemic area. On the high end, hydroxychloroquine is taken as 200 mg to 400 mg daily for rheumatoid arthritis.

Why are hydroxychloroquine and chloroquine being mentioned with COVID-19?

Recent in vitro studies (studies done in a petri dish or test tube rather than in animals or humans) have shown that both hydroxychloroquine and chloroquine have antiviral properties against SARS-CoV-2, the virus that causes COVID-19. In these studies, these medications worked by interfering with the chemical environment of human cell membranes. This blocked the virus from entering and multiplying inside the cells. A medication working in vitro does not always mean that it will work once inside a human body. Nonetheless, based on these early findings, hospitals worldwide have begun using hydroxychloroquine and chloroquine for patients with COVID-19. On March 28, 2020, the FDA issued an Emergency Use Authorization (EUA) that allows providers to request a supply of hydroxychloroquine or chloroquine for hospitalized patients with COVID-19 who are unable to join a clinical trial. The EUA does not mean that the FDA has approved these medications for the treatment of COVID-19. The intent of the EUA is to help increase access to these medications by allowing doctors to request a supply from the Strategic National Stockpile for these specific cases.

What do research studies say about hydroxychloroquine, chloroquine, and COVID-19?

Data is still extremely limited. We need more research to determine the best dose, when to give it and for how long, and how the risks and benefits of these medications stack up in the fight against COVID-19. Large, randomized, controlled trials (the gold standard for clinical trials) are needed to confirm many of the findings summarized below. HOW TO ORDER HERBAL & LIQUID INCENSE? Vaccines & Drugs: The Way Forward for Covid-19 5 Important Factors To Note About The Corona Virus Several studies have gained a lot of attention in recent media reports. We break it down between those that suggest the medications work compared to those that did not see a benefit. (Please note that even though results are being shared, few have been accepted into peer-reviewed medical journals.) Studies with positive results for hydroxychloroquine and chloroquine in COVID-19 Study 1 – March 16, 2020 Researchers from China reported in a letter that over 100 people with COVID-19 have been treated with chloroquine. These patients had less severe disease and a shorter illness duration compared to those who did not receive chloroquine. However, results from these studies are not yet available, nor do we have a lot of information about the type of people who received this drug, or what dose they took and for how long. Study 2 – March 20, 2020 A small study in France reported that people who got 600 mg of hydroxychloroquine had a lower amount of the virus (viral load) in the body. The problem with this study is that comparisons were made between patients at different hospitals. This makes it difficult to know if improvements were because of hydroxychloroquine or other things. And, of the 26 people who initially got hydroxychloroquine, 6 people (23%) had to stop treatment because of nausea, worsening disease, leaving the hospital, or death. Six people in this study also received azithromycin (a common antibiotic) with hydroxychloroquine. These individuals had even lower viral loads at the end of the study compared to those who only got hydroxychloroquine. This research group later released another article looking more into hydroxychloroquine and azithromycin in a study of 80 people (including the 6 above). They noted that 93% had cleared the virus after 8 days. Because this study did not have a control group, it is unclear whether people who did not receive these medications would have seen similar results. Research with more people is needed to help us understand whether improvements were because of the combination of medications or other factors.  CAN I PURCHASE CANNABIS OIL CARTRIDGES? Vaccines & Drugs: The Way Forward for Covid-19 5 Important Factors To Note About The Corona Virus More information on safety is also important because taking azithromycin and hydroxychloroquine together can increase the risk of serious side effects, particularly irregular heart rhythm. Study 3 – March 31, 2020 A small, randomized study of 62 people in Wuhan, China looked at how well hydroxychloroquine worked for hospitalized patients with mild COVID-19. Cough and fever improved about 1 day earlier for those who got 400 mg of hydroxychloroquine for 5 days compared to those who did not get any. Additionally, pneumonia improved in 25 of 31 patients who received hydroxychloroquine (compared to 17 of 31 in the group who didn’t). Studies with negative results for hydroxychloroquine and chloroquine in COVID-19 Study 4 – March 24, 2020 In a small Shanghai study of 30 people with COVID-19, half got 400 mg of hydroxychloroquine for 5 days while the other half did not. At the end of the study, 13 people (87%) who received hydroxychloroquine tested negative for COVID-19 compared to 14 people (93%) who also tested negative but did not receive the medication. This suggests that hydroxychloroquine did not make a difference in recovery. Study 5 – March 30, 2020 Another small study in France wanted to verify the results of Study 2 above, so they gave 11 people the same combination of hydroxychloroquine and azithromycin. After 6 days, 8 of 10 patients were still positive for SARS-CoV-2 (1 person could not be tested due to death). In addition to the death, two people were transferred to the ICU and one had to stop treatment due to side effects. This study was short and, like another study above, did not have a control group to compare patients to. Study 6 – April 14, 2020 In a study of patients hospitalized with COVID-19, 150 people were randomly assigned to either receive high doses of hydroxychloroquine (1,200 mg for 3 days, then 800 mg for 2-3 weeks) or not. At the end of the study, 85% of the patients who got hydroxychloroquine tested negative for the novel coronavirus compared to 81% who did not get the medication. The typical time it took for people to clear the virus and see improvements in symptoms was also similar between groups. About 30% reported side effects, though they were mostly mild. Study 7 – April 21, 2020 A retrospective study looked at veterans affairs (VA) hospitals across the U.S. and identified 368 male veterans who were hospitalized with COVID-19. The veterans were grouped based on whether they had received (1) hydroxychloroquine, (2) hydroxychloroquine and azithromycin, or (3) no hydroxychloroquine.  Death rates were highest in the group that received hydroxychloroquine alone (28%), followed by the group that received hydroxychloroquine and azithromycin (22%). The group that did not receive hydroxychloroquine had the lowest death rate (11%). 

One thing to note is that people who had more severe symptoms, which might partially explain the higher death rates, were also more likely to get medications. People in this study were over 65 years old (on average) and male, which makes it difficult to apply the results to everyone. Study 8 – May 7, 2020 In a large observational study of 1,376 hospitalized patients with COVID-19 in New York City, 811 people (59%) received hydroxychloroquine. There was minimal difference in the risk of needing a breathing tube (intubation) or death between those who didn’t get hydroxychloroquine and those who did. Because this study was observational (meaning the researchers only looked at the end results and were not involved with treatment), it is possible that other factors (confounders) may have affected the findings. Regardless, the researchers concluded that their study does not support the use of hydroxychloroquine for COVID-19. Study 9 – May 11, 2020 Another large observational study of 1,438 hospitalized patients with COVID-19 in New York state also did not see a difference in death rates between those who got hydroxychloroquine (with or without azithromycin) compared to those who did not. Again, because this was an observational study, other factors that were not measured could have also affected the results. Overall, hydroxychloroquine did not show a benefit in this study.

Are hydroxychloroquine and chloroquine safe?

Hydroxychloroquine and chloroquine are generally considered safe when taken for conditions that they have been approved for. If you currently take either of these for malaria or autoimmune conditions, you should continue taking them according to your doctor’s instructions. As with any medications, there are risks and benefits. Both hydroxychloroquine and chloroquine can cause side effects, but in these cases, the benefits outweigh the risk. 5 Important Factors To Note About The Corona Virus Where can I Order HASH Online? Vaccines & Drugs: The Way Forward for Covid-19 On April 24, 2020, the FDA issued a warning stating that using hydroxychloroquine or chloroquine for COVID-19 outside of a hospital setting can put people at risk of serious heart rhythm problems, particularly QT prolongation. This is a well-known side effect of these medications. Because there is still a lot we don’t know about COVID-19, it is unclear if COVID-19 itself increases this risk. Some hospitals in France, Brazil, and Sweden have had to stop using hydroxychloroquine and chloroquine for some coronavirus patients due to severe side effects. Taking hydroxychloroquine or chloroquine with other medications, like azithromycin, that can also cause QT prolongation, can further increase this risk. Prior to the FDA’s warning, several cardiology groups, including the American Heart Association, had issued a joint statement cautioning about the risks of taking these medications together.

Can hydroxychloroquine or chloroquine prevent or cure COVID-19?

At the time of this writing, hydroxychloroquine and chloroquine are not FDA-approved for the prevention or treatment of COVID-19. Additional data is needed to better understand the efficacy and safety of hydroxychloroquine and chloroquine for COVID-19. This is particularly important because current reports are based on a small number of patients, some who received dosages that were typically higher than what has been approved for other conditions. Hydroxychloroquine and chloroquine have not yet been shown to prevent COVID-19 either in a community or hospital setting. In the studies cited above, patients received these medications in the hospital only after they were confirmed to have COVID-19. Additionally, the FDA’s Emergency Use Authorization for hydroxychloroquine and chloroquine are only for hospitalized patients who are unable to participate in a clinical trial. Many clinical studies are currently underway to find a treatment for COVID-19, and the FDA is working with various government agencies, academic centers, and biopharmaceutical companies to expedite the process.

How can I get hydroxychloroquine or chloroquine?

Hydroxychloroquine and chloroquine both require a prescription from your doctor. Due to the recent increase in demand as a result of the COVID-19 pandemic, both medications are currently in short supply. This has made it difficult for patients with rheumatoid arthritis or lupus to get hydroxychloroquine, putting them at increased risk of complications. Many states have restricted pharmacists from dispensing certain medications unless it is specifically being prescribed for an FDA-approved use. Additionally, the American Medical Association, American Pharmacists Association, and American Society of Health-System Pharmacists issued a joint statement discouraging doctors and pharmacists from inappropriately prescribing medications such as hydroxychloroquine and chloroquine. This is to help prevent medication stockpiling and potential drug shortages.

What other medications are currently being used to treat COVID-19?

Researchers are studying many medications as potential treatments for COVID-19. Remdesivir, an investigational antiviral medication given via intravenous (IV) infusion, is one of these. Doctors are trying this medication on critically unwell patients in clinical trials across U.S. hospitals. It is also available through a compassionate use program for patients who do not qualify for the clinical trials. Access to remdesivir is temporarily paused due to overwhelming demand. CAN I PURCHASE CANNABIS OIL CARTRIDGES? Vaccines & Drugs: The Way Forward for Covid-19 HOW TO ORDER HERBAL & LIQUID INCENSE? Where can I Order HASH Online? SHOP CHLOROQUINE NOW 5 Important Factors To Note About The Corona Virus Read the full article