The strategies used by Pyne's group in the synthesis of these alkaloids can be summarised into three key steps:
reaction of a primary amine with an epoxide
the formation of a cycloalkene
the oxidation of the alkene group to form a vicinal diol.
"Chemistry" 2e - Blackman, A., Bottle, S., Schmid, S., Mocerino, M., Wille, U.














