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Allergies & Autoimmunity:
In Graves patients, during seasonal allergic rhinitis, when IgE increased so did thyroid autoantibodies, potentitally linking allergy flare-ups to the triggering of flare-ups in the disease. This didn't occur in patients without pollinosis. http://www.ncbi.nlm.nih.gov/pubmed/14646389
Food Allergy: Role of Vitamin D Gene Polymorphisms & Ethnicity "Vitamin D deficiency was associated with higher total IgE only in the carriers of the 'C' allele (IL4), which is present in 86% of white Europeans, while only 26% of Chinese and less than 20% of some African populations are carriers." (Vimaleswaran et al.)
Asthma: RANTES Among Potential Blood Tests & Targets For Treatment: "The serum levels of RANTES were significantly higher in all asthmatic patients than the controls. Moreover, RANTES levels were significantly increased in patients with moderate and severe asthma as compared to those with mild asthma. Serum RANTES correlated positively with absolute eosinophil counts and total serum IgE and negatively with FEV(1) . . .Serum RANTES may be used as a useful noninvasive marker of airway obstruction and a potential diagnostic tool for monitoring asthma severity. In this regard, identification and blocking of this chemokine and/or its receptor may be a promising therapeutic approach to asthmatic patients." (Saad-El-Din Bessa et al.)
