Can Trulicity Cause Extreme Fatigue?
Trulicity (dulaglutide) is a once-weekly injectable medication widely prescribed to help manage type 2 diabetes. It works by mimicking the natural hormone GLP-1, which helps regulate blood sugar, slow digestion, and reduce appetite. While it has proven effective for many patients, some users report experiencing a troubling side effect: extreme fatigue.
Is Fatigue a Side Effect of Trulicity?
Yes. Clinical studies show that 4–6% of people taking Trulicity report fatigue. While not the most common side effect, it is significant enough to be included in prescribing information. Many patients also describe it as severe or long-lasting, particularly in the first weeks of treatment.
Why Does Trulicity Cause Fatigue?
Several factors may explain why some people feel unusually tired on Trulicity:
Digestive changes: Nausea, reduced appetite, or diarrhea can lead to lower food and nutrient intake, draining your energy.
Dehydration: Trulicity slows digestion, and combined with side effects like vomiting or diarrhea, it may cause dehydration—a common trigger for fatigue.
Blood sugar fluctuations: Trulicity itself rarely causes hypoglycemia, but when taken with insulin or sulfonylureas, low blood sugar (which makes you feel weak and tired) can occur.
Adjustment period: Your body may need time to adapt to the medication, and tiredness often improves after a few weeks.
How to Manage Fatigue on Trulicity
If you’re experiencing fatigue while taking Trulicity, here are some strategies that may help:
Stay hydrated: Drink plenty of water throughout the day.
Eat small, balanced meals: Focus on nutrient-rich foods with protein, complex carbs, and healthy fats.
Time your injection: Some people find it easier to take Trulicity in the evening to minimize daytime fatigue.
Monitor blood sugar: Especially if you’re taking other diabetes medications.
Rest when needed: Allow your body to adjust to the medication.
Consult your doctor: If extreme fatigue continues, your healthcare provider may adjust your dose or explore alternatives.
When to Seek Medical Help
While fatigue can be a manageable side effect, extreme or persistent tiredness should not be ignored. It could signal dehydration, malnutrition, or complications related to blood sugar control. Always check in with your doctor if your fatigue interferes with daily life.
The Bottom Line
Trulicity can cause fatigue in some patients, and in certain cases, it may feel extreme. Fortunately, this side effect often improves with time and proper self-care. Staying hydrated, eating balanced meals, and monitoring your blood sugar can make a big difference. If tiredness doesn’t improve, talk with your healthcare provider to find the best solution for your diabetes management.