Fandoms & Things @the-hecate-kalivas - Tumblr Blog

When Drugs Became Available

Have you ever been writing some historical fiction and wondered "hey, I wonder if my characters would have been able to pop an ibuprofen in 1977?" Well, you're in luck, because this post is all about when common medications became available:

Acetaminophen: 1950

Albuterol: 1969 (UK) 1982 (US)

Allopurinol: 1966

Alprazolam: 1981

Amitriptyline: 1961

Amlodipine: 1990

Amoxicilin: 1972

Amphetamine/Dextroamphetamine (together as Adderall): 1996

Apixiban: 2012

Aripiprazole: 2002

Aspirin (first NSAID): 1899

Azidothymidine (first antiviral): 1987

Barbital (first barbiturate): 1903

Bupropion: 1985

Buspirone: 1986

Calcium Carbonate (TUMS): 1930

Captopril (first ACE inhibitor): 1981

Chlordiazepoxide (first benzodiazepine): 1960

Chlorothiazide (first thiazide diuretic): 1957

Chlorpromazine (first antipsychotic): 1952

Cyclobenzeprine: 1977

Diphenhydramine: 1946

Furosemide: 1959

Fluoxetine (first SSRI): 1988

Gabapentin: 1993

Glipizide: 1984

Hydrochlorothiazide: 1959

Ibuprofen: 1969 (UK) 1974 (US)

Insulin: 1923 (though many types of insulins would become available over the next century)

Imipramine (first tricyclic antidepressant): 1959

Iproniazid (first antidepressant (MAOI)): 1952

Levothyroxine: 1927 (though desiccated pork thyroid was used for the same reasons as early as 1890)

Lisinopril: 1987

Lithium: 1949

Losartan (first ARB): 1995

Lovastatin (first statin): 1987

Naproxen: 1976 (Rx) 1990 (OTC)

Nitrogen Mustard (first chemotherapy agent): early 1940's

Methotrexate: 1947

Methylphenidate: 1954

Metformin: 1957 (France) 1995 (US)

Metoprolol: 1978

Montelukast: 1998

Morphine: early 1800's

Omeprazole: 1989

Penicillin: 1945

Phenbezamine (first antihistamine): 1942

Prednisone: 1955

Propranolol (first beta blocker): 1965 (UK) 1967 (US)

Sertraline: 1990

Spironolactone: 1959

Sulfanilamide (first modern antibiotic): 1935

Tolbutamide (first oral anti-diabetic drug): 1956

Tramadol: 1977 (Germany) 1995 (US)

Trazodone: 1981

Valacyclovir: 1995

Verapamil (first calcium channel blocker): 1964

Warfarin: 1954

Zopiclone (first "Z-drug"): 1986

macgyvermedical

Someone asked for this list in date order, so here it is!

Morphine: early 1800's

Aspirin (first NSAID): 1899

Barbital (first barbiturate): 1903

Insulin: 1923 (though many types of insulins would become available over the next century)

Levothyroxine: 1927 (though desiccated pork thyroid was used for the same reasons as early as 1890)

Calcium Carbonate (TUMS): 1930

Sulfanilamide (first modern antibiotic): 1935

Nitrogen Mustard (first chemotherapy agent): early 1940's

Phenbezamine (first antihistamine): 1942

Penicillin: 1945

Diphenhydramine: 1946

Methotrexate: 1947

Lithium: 1949

Acetaminophen: 1950

Chlorpromazine (first antipsychotic): 1952

Iproniazid (first antidepressant (MAOI)): 1952

Methylphenidate: 1954

Warfarin: 1954

Prednisone: 1955

Tolbutamide (first oral anti-diabetic drug): 1956

Chlorothiazide (first thiazide diuretic): 1957

Metformin: 1957 (France) 1995 (US)

Furosemide: 1959

Hydrochlorothiazide: 1959

Spironolactone: 1959

Imipramine (first tricyclic antidepressant): 1959

Chlordiazepoxide (first benzodiazepine): 1960

Amitriptyline: 1961

Verapamil (first calcium channel blocker): 1964

Propranolol (first beta blocker): 1965 (UK) 1967 (US)

Allopurinol: 1966

Albuterol: 1969 (UK) 1982 (US)

Ibuprofen: 1969 (UK) 1974 (US)

Amoxicilin: 1972

Naproxen: 1976 (Rx) 1990 (OTC)

Cyclobenzeprine: 1977

Tramadol: 1977 (Germany) 1995 (US)

Metoprolol: 1978

Captopril (first ACE inhibitor): 1981

Trazodone: 1981

Alprazolam: 1981

Glipizide: 1984

Bupropion: 1985

Buspirone: 1986

Zopiclone (first "Z-drug"): 1986

Lovastatin (first statin): 1987

Azidothymidine (first antiviral): 1987

Lisinopril: 1987

Fluoxetine (first SSRI): 1988

Omeprazole: 1989

Amlodipine: 1990

Sertraline: 1990

Gabapentin: 1993

Losartan (first ARB): 1995

Valacyclovir: 1995

Amphetamine/Dextroamphetamine (together as Adderall): 1996

Montelukast: 1998

Aripiprazole: 2002

Apixiban: 2012

macgyvermedical

Don’t worry, there was plenty of amphetamine before that. Methamphetamine and dextramphetamine were very popular and available without a prescription in the 1930s.

marithlizard

The idea of life without either ibuprofen or acetaminophen makes me shudder. The amount of chronic pain people must have been in, all the time - must still be in, since even now many people can't get them - reminds me of that quote about how we have never met a fully sane, non-traumatized person.

hometoursandotherstuff

1893 Queen Anne Victorian in Newton, MA has 8bds, 6ba, 5,822sqft, $1.995m (Zillow's est.: $2,166,900)

nateconnolly

At the library where I work there’s a bookcase where everyone on staff gets a shelf for books that they recommend and I’ve had more of my recommendations checked out than any other employee. I truly believe I will go mad with power by the end of the work week

nateconnolly

In all honesty I think this is just because my coworkers are essentially splitting the vote. They’re all recommending, like, brand name thrillers and romance novels. Meanwhile I am the only person at the public library recommending occult lore

nateconnolly

cryptid-deity

[Image description: a comic panel of people filing into the City Library. One person says, "Let's go into the occult book section and get a rundown on witchcraft!". End description.]

wheelie-sick

for the lovely lovely deafies out there who want to get involved in direct action you absolutely 100% cannot ever bring a hearing aid or cochlear implant with bluetooth to any direct action. bluetooth devices all carry a unique signal that can be used to identify you if it's picked up at a direct action. go with a [more] hearing buddy and communicate in sign language. if you don't mutually know a sign language then come up with gestures. do not risk your freedom because you want to have your hearing aid/cochlear implant at the action. it's not worth it.

wheelie-sick

flock cameras are also now tracking bluetooth device signatures when you pass them. if you drive past a flock camera with your bluetooth-enabled hearing aid or cochlear implant, the flock camera knows you passed through

thewolfwaitsbelow

Wait I just realized this is gonna apply to all cgms and most if not all insulin pumps. They’re all Bluetooth devices, it’s essential to how they work

ailithnight

I did not think it possible, but I have just developed even more hatred, derision, and contempt for the perpetual surveillance state.

argumate

instead of "people pleaser" it might be better to think "disapproval fearer" if that's the emotional stick that's motivating action; important to consider at least three reasons to do something:

it's a good thing to do

I want to do the thing

people will be mad if I don't do the thing

and if 3. is the most weighty reason then that's a potential problem.

headspace-hotel

Here's an idea about why kids are so anxious and depressed all the time...the environments kids are in most of the time are very stressful and don't fulfill their needs for play, rest, proper variety of foods, positive social opportunities, and freedom from fear pain punishment etc

velvetcloak

👏👏👏

fox-bright

So--when I was in my mid-twenties and the Disaster Ex tried to make me kill myself, the local mental hospital didn't have any beds open in the usual ward for attempted suicides.

What they did have was a single spare bed in the small, comfortable, quiet, wildly expensive facility for girls with eating disorders.

They asked each of the young women currently living there if it was acceptable that I might occupy a bed in one of the rooms for a while, just the long weekend while I was waiting for a doctor's evaluation. I hadn't been violent, I had gone with the cops without putting up any fight at all, and I was still and I was small and all those things were sufficient for me to be deemed safe. So up they sent me, to somewhere high in Western Psych, above the smells and sounds of the denser-packed wards, above where the care workers were harried and frustrated, to a gentle space with seven or eight young women in it.

I was five foot three, and I weighed about 115 pounds. I was underweight for my frame, as a fair amount of that weight was martial arts muscle; I would probably have been ten pounds heavier if I were healthy, with the amount of activity I got.

I was at least two inches shorter than pretty much every other young woman there, six or seven inches shorter than one of them, and I had at least thirty pounds on several of them. The tallest was not allowed to walk, she had to sit in a wheelchair and be pushed around, because her condition was so advanced that the motion would undo what good her hard work had done.

And over the course of the four or five days I was there, multiple of them came up to me alone to quietly tell me that I had the *perfect* body, and they wished they could be as skinny as I was. That I needed to live, because I was beautiful, and if they were as beautiful as I was, they wouldn't need to be here.

Their eyes were on me all the time, in the hours that I wasn't sleeping. I spent a lot of time sleeping, and we took our meals separately (I not needing to be monitored while I ate, and not having my food weighed), but we spent a fair amount of time sitting around in the little shared living room space, talking about movies and magazines and books we'd loved, talking about our families. I didn't talk about my family; they didn't pry.

They were all so fucking nice.

And I could have broken any one of them over my narrow knee. They each thought they were bigger than I was.

Their brains lied to them, every time they looked at a mirror. Every time they looked down at their own thighs. What they saw was not what I could see. They had bright, beautiful eyes in dark hollows, and I could count their vertebrae, could see their ribs winging when they breathed, could see the motion of every tendon on the backs of their hands.

They weren't celebrities. They weren't being paid to have particular bodies, nor were they deep in the toxic sea of having strangers take photos of them to sell to gossip rags if they stepped out of doors in old jeans. They had families and loved ones who were doing everything that they could to protect them, to uplift them and help them be healthy. They were just everyday people--a nurse, a couple of students, a couple of recent college grads, a young woman who had decided it was time to really get help because she wanted to be a mother--and still they'd been so injured by the neverending fucking deluge of body-image bullshit that they were dying of it.

That was in 2009. Things are worse now. I think about them still. I hope that they're all right.

likorys-shimenawa

And in case some people aren't aware: anorexia is deadly. There is a point at which your body looses the ability to digest food and you are no longer capable of improving.

bunnygirljesus

Black ppl deserve to feel safe and welcomed on the internet, on fandoms on whatever community or hobbies they want without having to deal with antiblack racist attacks, microaggressions or enablers of antiblackness . And if u genuinely consider urself to be left leaning or an ally or woke you should do and try to unlearn the colorism, texturism , eurocentrism and antiblackness

derinthescarletpescatarian

I love visiting people who have some kind of pet reptile because they're always like "would you like to hold the reptile" and I'm like "of course I would" and then the rest of the conversation happens with me just holding a random reptile and the reptile Has No Feelings about the situation. They always just sit there, probably vaguely wishing to return to their heat lamp but clearly exuding an energy of This Might As Well Happen. and then I put it back in its enclosure and go home and the reptile very clearly has no strong feelings about the situation.

derinthescarletpescatarian

#my environmental science teacher in sophomore year had a classroom snake. and it was exactly like this#just a bunch of teenagers gently passing a snake to each other and doing lab work#and the snake would be like. yup. im just here.

originalzin

A relevant gift for all your holiday needs~

auxphono

Please please please don't click those phishing texts

auxphono

aropride

please god let chatgpt die out like nfts did. With a fast and graceless fall into irrelevancy

bladespark

Like to charge, reblog to cast.

atwotonedbird

This spell has a very low hit ratio, so we need a lot of us to do it.

hotvampireadjacent

allthingswhumpyandangsty

wattpad really gave ao3 a huge free promo with their new policy update that makes things even worse for their users. so to all the people who are now moving to ao3 due to this…

welcome! here are what you need to know about ao3 and how it’s the complete opposite of wattpad

trigger warning for the mention of contents that are allowed on ao3 that can be triggering to some.

ao3 is a non-profit organization. it’s run by fans (people like you and me), for fans.

fans donate to the site on their own free will to keep the site up and running smoothly.

ao3 is not a social media. it is an archive.

ao3 doesn’t have ads. it doesn’t have algorithms. it doesn’t have “going viral.”

everything is endlessly free on ao3. there is no “ao3 premium.” you will never see a single ad on ao3, and you can download as many fics as you want to read offline for free.

ao3 doesn’t have an app. and ao3 doesn’t need an app. any “ao3 apps” you see are third-party apps and are not affiliated with ao3, so be careful giving these shady apps your login infos or other personal information.

ao3 was built with the main purpose to 1.) be completely against censorship and 2.) host fics that are banned on other platforms like wattpad.

the reason ao3 doesn’t have an app is because for it to have its own app, appstore and google play store will have to approve it first. and due to the contents ao3 allow, chances are that it won’t get approved. which is actually a good thing. it doesn’t need an app. it works more than fine without an app.

on ao3, every single thing is allowed as long as it is fanfic or fan work (original works, fan art and video edits count as fan works, but if you want to post a video edits on ao3, you will have to post it elsewhere and then link it back to ao3 — ao3 cannot host video edits on its platform due to copyright issues)

by every single thing that is fanfic, I mean every single thing:

the filthiest smut without plot that is written purely for sexual pleasure is allowed. it has its own canonical tag called “plot what plot, porn without plot.”

fics that focus on non-consensual sexual intercourse are allowed, doesn’t matter if the fics glorify or romanticize the act, doesn’t matter if they’re written as kinks. they have their own canonical tag called “rape/non-con.”

fics about characters who are minors are allowed, even if they’re portrayed in a sexual manner, even if they’re non-consensual sexual intercourse. even if the minor characters are romantically and/or sexually involved with characters who are adults. even if they fics are written in ways that glorify and/or romanticize the thing. they have their own canonical tag called “underage sex.”

fics about incest are allowed. doesn’t matter if they glorify or romanticize the relationship. they have their own canonically tag called “incest.” fun fact: the first ever fic that was posted on ao3 was a fic about an incest ship from supernatural.

fics about self-harm and suicide are allowed. doesn’t matter if they glorify or romanticize the act. they have their own canonical tags called “self-harm” and “suicide” also “suicidal ideation”, “suicide attempt”, “implied/referenced suicide”, etc.

fics about violence and gore are allowed, even if they were written for the sake of shock value. they have their own canonical tag called “violence”, “blood and gore”, “blood and injuries”, etc.

rpf is also allowed. doesn’t matter if the content of the fics are dark and taboo. they’re treated the same way as any other fics.

every single dark and taboo fic you can think of is allowed. and it has its own canonical tag. because it is the main reason why ao3 was created in the first place.

“but what do I do if I don’t wanna see fics about xyz?” you can filter out any specific tag, character and/or pairing you want.

“what do I do if I wanna find fics about xyz?” you can search for any specific tag, character and/or pairing you want.

a lot of ao3 users rely on tags to search for specific tags, pairings, characters they want. they also rely on tags to filter out and exclude specific tags, pairings, and characters that they don’t want to see.

ao3’s tagging system is by far the most efficient one I’ve ever seen.

on ao3, our main principles are “don’t like don’t read” — which means YOU have a responsibility to curate your own internet experience. yes, ao3 allows all kind of messed up fics, but they also allow you the ability to NOT see anything you don’t want to see, by filtering out specific fics, pairings and/or characters.

no. you cannot harass authors who write about things that disgust you. you can and will be reported for harassment, and ao3 takes harassment very seriously. they will not take your side. because fucked up fics are allowed on ao3—fucked up fics are the main reason ao3 was created—whereas harassment is a direct violation of their terms of service.

ao3 is a house of the freaks and the perverts (affectionate). you ARE in the house of the freaks and the perverts. so don’t think about harassing or being rude to the freaks and the perverts who built this anti-censorship house and are kind enough to let you in.

ao3 is proship, profic, and anti-censorship.

any writer can write whatever they want, however they want. the only etiquette is that you tag your stuff properly and accurately

mistagging for visibility is heavily frowned upon here, and it won’t get your works more views. people will either block or report you if you deliberately mistag things with the purpose of getting your fic more views. as I’ve said before, ao3 is an archive. it’s not a social media. it doesn’t have algorithms or going viral.

if you come across a fic that has the tag “creator chose not to use archive warnings” it means the fic may or may not contain topics that can be triggering, but the author won’t tell you what these topics are, or if there are any at all. so proceed at your own risk.

that said, because ao3 is a non-profit site that hosts millions of works about others’ copyrighted characters, you CANNOT link a monetization platform anywhere on ao3, you CANNOT mention any donation, commission—or anything that involves money—anywhere on ao3. no, you cannot imply donation, commission, or anything that involves money either. that is against their terms of service.

and because ao3 is a place for fanworks, the “work section” of your post has to actually be fanwork (fanfic, original work, fan art, link to a video edit count as fanwork). anything that isn’t fanwork is not allowed.

you cannot post something on ao3 that is not fanwork. so no political statement, no call-out post, no “I’m looking for fics about xyz”.

ao3 is anti censorship as long as what your post is actually fanwork and as long as you don’t violate their terms of service that I’ve mentioned above.

ao3 has their own team of lawyers to protect them, their users, and every fanwork that is posted on their platform.

last but not least, don’t write directly onto ao3. write and store your works elsewhere before copy and paste them onto ao3 once they’re ready to post!! because ao3 does NOT autosave drafts for you, you risk losing everything you’ve typed if there’s a glitch, if the site crashes or if your device unexpectedly shuts down for whatever reason.

that’s all for now. have fun and happy writing/reading!