I've said this before, but to keep things clear I'll say it again. I believe in Wolfstar up until October 31st of 1981 (assuming the fic doesn't go way off from the canon storyline). But after that? When Sirius is imprisoned and Remus is left all alone, I can't see it ever recovering.
The two, Sirius and Remus, are just too different. They've changed in ways they can't return from. No longer are they the boys so commonly discussed in Fanon—the boy who goes through excruciating pain every month and allows his friends to be there for him during it. Nor is Sirius the boy who is willing to illegally become an animagus just so his friend isn't alone on the full moons, something which can result in Azkaban.
Sirius becomes an innocent man too broken to escape from a prison. In fact, it's only a picture of Pettigrew that makes him. Remus is a man abandoned, believing all his closest friends are dead or a traitor. He's so broken from it all, and the continued lonely full moons, that he leaves Harry with Petunia despite knowing the woman.
They're no longer two dorm mates with a boat load of chemistry. They're men who have weathered far more than they should have had to, and they're changed. And, in my opinion, I don't think the people they became would be able to be in a relationship, even if they did love each other.