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Say Goodbye to Store Lines - Order (Capecitabine) Xeloda Online

Seepage the hassle of waiting in long store lines for your health products. Embrace convenience by ordering your (Capecitabine) Xeloda online. With just a few clicks, have your products delivered to your doorstep. Say goodbye to the stress of store visits – streamline your healthcare experience and enjoy the ease of online product ordering.

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Adjuvant Capecitabine for Early Breast Cancer: 15-Year Overall Survival Results From a Randomized Trial

The Finland Capecitabine Trial (FinXX) is a randomized, open-label, multicenter trial that evaluates integration of capecitabine to an adjuvant chemotherapy regimen containing a taxane and an anthracycline for the treatment of early breast cancer. Between January 27, 2004, and May 29, 2007, 1,500 patients with axillary node-positive or high-risk node-negative early breast cancer were accrued. The patients were randomly allocated to either TX-CEX, consisting of three cycles of docetaxel (T) plus capecitabine (X) followed by three cycles of cyclophosphamide, epirubicin, and capecitabine (CEX, 753 patients), or to T-CEF, consisting of three cycles of docetaxel followed by three cycles of cyclophosphamide, epirubicin, and fluorouracil (CEF, 747 patients). We performed a protocol-scheduled analysis of overall survival on the basis of approximately 15-year follow-up of the patients.

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About Capecitabine (Xeloda)

Capecitabine interferes with DNA production. This stops cell growth and division, resulting in the slowing or stopping of cancer growth. Since cancer cells, in general, divide faster and with less error-correcting than healthy cells, cancer cells are more sensitive to this damage.

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How is capecitabine taken?

Capecitabine is taken in cycles. Your specialist will prescribe a dose and regime that is appropriate for you. The drugs used, the dose, how often they’re given and the number of cycles may be called your chemotherapy regime or regimen.

Capecitabine is available in two different tablet strengths: 150mg or 500mg. You will be told how many of each tablet to take to make sure you get the right amount each day for your body size.

You will usually take the capecitabine tablets twice a day (in the morning and evening) for 14 days and then have a seven-day break from taking the tablets. This 21-day period is one treatment cycle. If you are prescribed capecitabine differently to the 21-day cycle your doctors will explain why.

You should swallow the tablets with water within half an hour of eating a meal.

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XELODA contains the new chemical entity capecitabine (INN), a fluoropyrimidine carbamate.

Capecitabine is designed as a 'pro-drug' to the cytotoxic agent 5-fluorouracil (5-FU) and to be administered orally. 5-FU is a widely used cytotoxic agent. The human safety profile of 5-FU and its metabolite FBAL has been characterised through clinical trials and from many years of post-marketing experience.

The gastrointestinal absorption of capecitabine is nearly complete. Capecitabine is absorbed as unchanged parent substance but is subsequently substrate of enzymes and thus is nearly completely metabolised.

The metabolic pathway leads to production of 5’-DFCR via carboxylesterase (liver) and to 5’-DFUR via cytidine deaminase (liver and neoplastic tissue) and finally via thymidine phosphorylase to 5-FU. Thymidine phosphorylase is in higher concentration in neoplastic tissue, in comparison to healthy tissues, rendering capecitabine “tumour specific”. The catabolic pathway of 5-FU comprises dihydro5-fluorouracil (FUH2, via dihydropyrimidine dehydrogenase, DPD), 5-fluoro-ureidopropionic acid (FUPA) and α-fluoro-β-alanine (FBAL).

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WHAT IS CAPECITABINE?

Capecitabine is a chemotherapy drug. Chemotherapy is a treatment that destroys cancer cells using anti-cancer drugs. Capecitabine is the non-branded name of the drug, but you may also hear it called by its brand name Xeloda. You may find it useful to read this booklet alongside our Chemotherapy for breast cancer booklet. If you’re taking capecitabine for secondary breast cancer (when cancer has spread from the breast to other parts of the body), you may want to read our Secondary breast cancer information pack.