Scary Chart of the Day: SOFR Volume
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Scary Chart of the Day: SOFR Volume
The meme economists say you should be afraid...very afraid.
Silver is Surging. Is it 1929 in 2025?
Startup Emrod says it can transfer electricity wirelessly. https://ift.tt/2DiX0N6
Acropora
semiconductorwave The Nikon NASA F4 Electronic Still Camera was one of the first and rarest fully digital cameras with development started in 1987. While Nikon delivered a modified Nikon F4 body, most of the electronics for the digital camera and housings were designed and built by NASA at the Johnson Space Center and other suppliers. It was first flown in September 1991 on board the Space Shuttle Discovery, mission STS-48. Later the cameras were flown on several other Shuttle missions including STS-44, 45, 42, 49, 53, 56 and 61.â
NASDAQ 100 sits on nearly $1T in cash â and weâve got the charts to prove it
Why âhuman-likeâ is a low bar for most AI projects
Tiny finger-like projections called filopodia drive invasive behavior in a rare subset of lung cancer cells, researchers at Winship Cancer Institute of Emory University have found. Adam Marcusâ lab has developed innovative techniques for separating âleadersâ and âfollowers,â subpopulations of tumor cells that cooperate during the process of metastasis. The labâs new analysis of what molecular features distinguish leader from follower lung cancer cells focuses on filopodia. The results are published in Science Advances.
âFilopodia are like the fingers of the cell, and help the cell pull its way forward,â Summerbell says. See the supplementary video for a depiction of filopodia and invasive behavior.
Having longer filopodia is linked with a gene called MYO10, which encodes a component of the internal cellular skeleton stabilizing filopodia, Summerbell and Mouw found. MYO10 was the gene that was the most up-regulated and hypomethylated in leader cells, compared with follower cells, and both long filopodia and invasive behavior depend on MYO10 activity.
âIt was known that MYO10 was linked to invasion and metastasis, but this is the first evidence that it is playing this specific role in a rare subset of cells,â Marcus says. âThis could help us look for these rare cells in patient tumors to gauge how potentially invasive they are.â
Leader cells also secrete fibronectin, a sticky extracellular protein, while follower cells do not. The MYO10 protein helps filopodia rearrange fibronectin molecules into fibrils, but it does not appear to interact with fibronectin directly.
âAs the leader cell filopodia pull on the extracellular matrix, they change this matrix from a random mesh into long parallel tracks in front of the cell, paving a road for a group of cells,â Summerbell says. Filopodia are sometimes described as resembling antennae â or precursors of more stable cellular structures. âWeâre observing that in leader cells, filopodia are not only sensors of the extracellular environment but also actively participate in reorganizing the extracellular matrix,â Marcus says. Summerbell and Mouw also studied other changes that distinguish leader cells, such as elevated expression of the Jagged1 gene. Jagged1 encodes a receptor for the Notch pathway, whose activity lies behind activation of MYO10. MYO10 and Jagged/Notch activation may be generalizable to patient samples and other types of cancer.
The paper involved collaboration with Jeanne Kowalski, PhD, now at University of Texas, Austin and Paula Vertino, PhD at University of Rochester.
The research was supported by the National Cancer Institute (R01CA236369, R01CA194027, R21CA201744, U54CA209992), including three student-initiated F31 grants (F31CA210601, F31CA186676, F31CA180511). Additional support came from the Integrated Core Facilities at Emory, Winship Cancer Institute developmental funds and a postdoctoral fellowship from the American Cancer Society.
Researchers at MIT and Brigham and Womenâs Hospital have designed a silicone rubber face mask that they believe could stop viral particles as effectively as N95 masks. The masks are based on the shape of the 3M 1860 style of N95 masks normally used at Brigham and Womenâs Hospital. Most of the mask is silicone rubber, and there is space for one or two N95 filters, which are designed to be replaced after every use, while the rest of the mask can be sterilized and reused. This image shows the mask on a mannequin head.
Scientists used human stem cells to build a new rat intestine
Scientists have built a new rat intestine by combining part of the animalâs own bowel with human stem cells. One day, this method could be used in humans with intestinal problems who currently have to rely on organ transplants.
A variety of diseases, including Crohnâs disease, lead to people having short bowels, which makes it harder for their bodies to absorb nutrients.Â
One common solution is bowel transplant, but there is a shortage of intestines and, as with all transplants, the patientâs body often rejects the new organ. For a study published today in the journal Nature Communications, researchers grew new intestines in the lab. Read More
The possible future of diabetes regulation: smart contacts.
Learn about new gTLDs and how they could affect (or not affect) your business - analystdistrict.com
Vegetative Patient Uses His Thoughts to Tell Doctors He Is Not in Pain
A 39-year-old Canadian man believed to have been in a vegetative state for 12 years has been able to communicate using the power of thought, proving that he is conscious and aware of his condition.
Scott Routley, who was left severely brain damaged after a car crash, was able to tell his doctors he is not in any pain by using a pioneering question-and-answer technique using fMRI imaging.
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