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Progeria, also known as Hutchinson-Gilford progeria syndrome (HGPS), is a rare genetic condition that causes a child's body to age fast. Progeria, any of several rare human disorders associated with premature aging. The two major types of progeria are Hutchinson-Gilford syndrome, which has its onset in early childhood, and Werner syndrome (or adult progeria), Most kids with progeria do not live past the age of 13. The disease affects both sexes and all races equally.

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Introduction to Progeria Syndrome

This video was made for a university biology course project. It explains what progeria syndrome is, what causes it, which symptoms are associated with it, an...

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Thirty years ago, virtually nothing was known about progeria, and due to the rarity of the disease, little research was done until the 1990s.In 2003, NIH-funded researchers discovered that Hutchinson-Gilford progeria is caused by a tiny mutation in a single gene, known as lamin A (LMNA). In laboratory tests involving cells taken from progeria patients, researchers found that the mutation responsible for Hutchinson-Gilford progeria causes the LMNA gene to produce an abnormal form of the lamin A protein which destabilizes the patient’s cells. On the other hand Otto Werner originally defined Werner syndrome (WS) in 1904 on the basis of sclerodermalike, thin, tight skin and bilateral cataracts. WS is also known as progeria adultorum, progeria of the adult, and pangeria. WS is the most common of the premature aging disorders. 

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Progeria affects approximately 1 in 20 million people.  There are an estimated 350-400 children living with Progeria worldwide at any one time.  It affects both sexes equally and all races.  Since The Progeria Research Foundation was created in 1999, we have discovered children with Progeria living in 52 countries and speaking 32 languages. HGPS is not usually passed down in families. The gene change is almost always a chance occurrence that is extremely rare.

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As children with progeria get older, they get diseases you'd expect to see in people age 50 and older, including bone loss, hardening of the arteries, and heart disease. Children with progeria usually die of heart attacks or strokes. Progeria doesn't affect a child's intelligence or brain development at all. A child with the condition isn't any more likely to get infections than other kids, either.

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Children with progeria do not begin showing symptoms until around 18-24 months; typically they are born looking healthy.

Doctors may suspect progeria based on signs and symptoms characteristic of the syndrome. A genetic test for LMNA mutations can confirm the diagnosis of progeria.

A thorough physical exam of your child includes:

·         -Measuring height and weight

·         -Plotting measurements on a normal growth curve chart

·         -Testing hearing and vision

          -etc

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As newborns, children with progeria usually appear normal. However, within a year, their growth rate slows and they soon are much shorter and weigh much less than others their age. While possessing normal intelligence, affected children develop a distinctive appearance characterized by baldness, aged-looking skin, a pinched nose, and a small face and jaw relative to head size. They also often suffer from symptoms typically seen in much older people: stiffness of joints, hip dislocations and severe, progressive cardiovascular disease. Most kids with progeria do not live past the age of 13. There is an increased tendency to develop heart disease, diabetes mellitus, and cancer, and the average life span is 47 years. Werner syndrome is caused by mutations in the gene WRN (Werner syndrome, RecQ helicase-like). This type of progeria is hereditary and is transmitted as a recessive trait(two copies of the mutated gene, one from each parent, are required to cause the disease).

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There's no cure for progeria, but regular monitoring for heart and blood vessel (cardiovascular) disease may help with managing your child's condition.

During medical visits, your child's weight and height is measured and plotted on a chart of normal growth values. Additional regular evaluations, including electrocardiograms and dental, vision and hearing exams, may be recommended by your doctor to check for changes.

Certain therapies may ease or delay some of the signs and symptoms. Treatments depend on your child's condition and symptoms. These may include:

·         -Low-dose aspirin. A daily dose may help prevent heart attacks and stroke.

·         -Other medications. Depending on your child's condition, the doctor may prescribe other medications, such as statins to lower cholesterol, drugs to lower blood pressure, anticoagulants to help prevent blood clots, and medications to treat headaches and seizures.

·         -Physical and occupational therapy. These therapies may help with joint stiffness and hip problems to help your child remain active.

·        -Nutrition. Nutritious, high-calorie foods and supplements can help maintain adequate nutrition.

·        -Dental care. Dental problems are common in progeria. Consultation with a pediatric dentist experienced with progeria is recommended.

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Current research seeks to understand progeria and identify new treatment options. Some areas of research include:

·         -Studying genes and the course of the disease to understand how it progresses. This may help identify new treatments.

·         -Studying ways to prevent heart and blood vessel disease.

·         -Performing human clinical trials using drugs known as        farnesyltransferase inhibitors (FTIs), such as lonafarnib, which were developed for treating cancer, but may be effective for treatment of progeria by helping with weight gain and increased flexibility of blood vessels.

·         -Testing other drugs for treatment of progeria.

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The MISSION of The Progeria Research Foundation: To discover treatments and the cure for Progeria and its aging-related disorders, including heart disease. Progeria is a rare, fatal, “rapid aging” disease. Without the discovery of new treatments, all children with Progeria will die of heart disease at an average age of 14 years. The Progeria Research Foundation (PRF) was founded in 1999 in response to the complete lack of progress being made to help children with Progeria. Our original mission: to discover the cause, treatments and cure for Progeria.* Today, PRF continues to be the only organization in the world solely dedicated to this mission. We have filled a void, taking these children out of the background where they had been for over 100 years and putting them and Progeria at the forefront of scientific efforts.

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[melisica]

[raviooli]

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A true Christian Filipino is a family oriented person. For a family is my strength and my weakness.

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My family used to be close when all of us were staying here in Iligan then suddenly my grandmother decided to go to manila after my grandfather died to live with her sister to ease the pain that she felt when my grandfather died.

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As with most popular sayings, there is some truth in the adage, “Great leaders are born, not made.” To some extent, the capacity for great leadership is innate. However, learning how to be a more effective leader is within everyone’s grasp – whether you lead multiple teams, an entire company or just one staff member. A good leader takes the lead. A good leader has personality, courage, clear vision with ambition to succeed. A good leader encourages the team to perform to their optimum all the time and drives organisational success. So what is leadership? One great definition is: “Leadership is the art of leading others to deliberately create a result that wouldn’t have happened otherwise.”

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My Kind Of Love

Love is one of the most profound emotions known to human beings. There are many kinds of love, but most people seek its expression in a romantic relationship with a compatible partner. For some, romantic relationships are the most meaningful element in their lives, providing a source of deep fulfillment. The ability to have a healthy, loving relationship is not innate. A great deal of evidence suggests that the ability to form a stable relationship begins in infancy, in a child's earliest experiences with a caregiver who reliably meets the infant's needs for food, care, protection, stimulation, and social contact. Those relationships are not destiny, but they appear to establish patterns of relating to others.

Failed relationships happen for many reasons, and the failure of a relationship is often a source of great psychological anguish. Most of us have to work consciously to master the skills necessary to make them flourish. In short Love means knowing that no matter what, you have someone to count on. It's unconditional and makes you feel good on the inside. You can trust the person you love and are comfortable around them. It's like your heart tells you that it is good for you.