This is her title card at 00:02:51. note the colors. Prominent pink white and blue. Hm. Interesting.
The first frame we see of Gwen onscreen is at 00:01:24. She is pink, the other prominent colors are blue and white. She's drumming, she's feeling her emotions, she's expressing herself.
as the scene moves forward, her bandmates confront her, essentially asking "what's wrong?", and she can't tell them about anything she's thinking because everything involving her life as Spider-Woman is a secret. One could say she is "in the closet." During this scene, her bandmates have more realistic skin tones, while Gwen is blue.
The next scene, with Gwen and Peter having dinner with George (Gwen's dad) and Aunt May, Peter has photos he's taken of Spider-Woman. Gwen asks about this "dangerous menace", Peter (who has figured out her secret) defends Spider-Woman. George (a cop) says "Why wear a mask if you have nothing to hide?", shutting down any chance that Gwen could "come out" to him. Aunt May shuts the conversation down with "No politics at the dinner table." and winks at Gwen, protecting her. One could read this as Gwen having "come out" to Aunt May.
Note the pink dress. The blue necklaces. The rainbow pin.
In the scene starting at 00:05:50, Gwen is walking through vibrant yellow/orange/pink city streets, shielded and isolated from the world in blue, after her best friend died. She is listening to her father condemn Spider-Woman for the murder. She's alone, with the only person who knew her secret gone forever.
George's badge is a trans flag (00:06:03)
Gwen seeing her reflection as Spider-Woman, not the person everyone else sees. (00:06:10)
George proceeds to tell her that they've caught a break in the Spider-Woman case. Gwen's father is actively hunting for her without knowing it. He's a cop, she's in danger. Gwen is still blue.
at 00:07:20, George drops the cop stuff and talks to Gwen as her father and they hug. Gwen is vulnerable for the first time since the very first frame, and the blue drops away and the world starts to fill with warmer colors.
The hug ends at 00:07:33 when George's radio goes off. He's back in cop mode. And Gwen turns blue again. Because she is hiding from him for her own safety.
I think it's notable to point out that up to this point, everyone else's skin tones have been consistently normal, with differences coming from exterior lighting. By contrast, Gwen has been pink when no one is looking, blue whenever she is being perceived, and something closer to normal when she's allowed to just be a teenage girl hugging her dad.
We get a close-up of Gwen putting on her suit as the movie transitions to the next scene. Her face is a much more realistic color as she puts on her mask, the physical Spider-Woman costume allowing her to drop the blue shield she's been wearing onscreen so far this movie. (00:08:03)
This is the first eight minutes of the film. I wonder why a trans woman could identify with this.