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Drug Development Process: From Laboratory To Clinic

Drug development is a process that starts with the idea for an effective treatment, goes through stages of research and testing, and ends with a successful drug that can be sold by a large pharmaceutical company. The drug development process depends on having the right people in place. These people include scientists and engineers who develop your blueprint for making drugs. In the early stages of drug development, many different types of people are involved in this process.

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All the Non-technical Information You Need To Know About Luminex Cytokine Multiplex

Luminex BioPlex Bead Array System offers easy, affordable, and accurate labeling with a broad range of cytokines and antigen-specific detection solutions. A unique approach to diagnostics, Luminex BioPlex Bead Array System is ideal for single-bead based phenotyping applications whenever results require high sensitivity, user-friendly results and labeling efficiency.

Luminex cytokine and multiplex assay provides real-time, simultaneous detection of over 100 cytokines and other analytes in serum or plasma for clinical laboratory use. Luminex BioPlex bioreactor integrates the technology in one system to allow the seamless conduct of multiplexed assays.

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How do you build a bioanalytical method?

While bioanalysis enables us to see things that are not visible to the naked eye, this is still a subjective process. Developing and validating bioanalytical methods require a lot of knowledge, experience, and resources. Without our experts helping you along the way, you would never get there.

How do you build a bioanalytical method? First, you have to understand how it works. Then, you have to develop a way to study that process and measure your data to validate what you found. Only then will it be ready for your customers and clients to begin using.

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Toxicology Studies for the New Drug Development Pipeline

Toxicokinetics studies are essential to the success of drug development, because they help to identify the toxicities of compounds and inform safer compounds that can be used in future development. In addition, toxicology studies provide information about the interaction of drugs with other pharmaceuticals and their action mechanisms to allow for informed decisions on how best to conduct studies related to toxicity in human subjects. We offer a broad range of toxicology studies  in drug development pipeline to help your company select the right approach.

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Luminex Announces Method Transfer To Increase Resource Effectiveness

Luminex has announced a resource transfer to increase the effectiveness of its bio-plex bead-based multiplex platform, which combines antigen capture and chemiluminescent detection into a single lab on chip (LOC). The resource transfer will enable Luminex to support up to five simultaneous immunoassays using the same sample.

Luminex  System is a diagnostic multiplex platform that enables next generation clinical testing. This new multiplex platform provides scientists with a broad set of tools to design more specific and accurate assays for their studies. Luminex BioPlex Multiplex Bead Assay Bundle is the reagent target-specific assay that does not require any consumables or predesigned reagents. It can be used in bioavailable forms of tests, biomarkers and targets

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Analytical Methods Given To The Pharmacist: Here's How They Work

If you're a pharmacist or work for an online pharmacy, chances are you need to know how to analyze medicines. That's why the team at the Natural Chemistry Department created these tools, which aim to streamline your life and make handling drugs.

Our pharmaceutics manufacturing, and analytical method transfer services ensure that all processes and procedures meet global regulatory standards before sending them to our approved manufacturing sites. All analytical results are reported with transfer methods and conditions. This website will explain the definitions of analytical method transfer in pharma.

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Development of a combined negative and positive mode for a combination LC-MS/MS method

An efficient multi-orbital mode for combination LC-MS/MS peak generation was developed as part of the Nebiolab platform. The negative and positive modes utilize different ions to generate a highly resolved protein spectrum. This method can be used in other analyte determination techniques such as MSn, QqQ and standard injection based MSn.

The combined negative and positive mode (CNP/CNP) of LC-MS/MS was developed with the objective to provide high sensitivity and reproducibility in identifying small molecules with this technique. Read more visit here:  https://www.nebiolab.com/positive-and-negative-mode-in-mass-spectroscopy/

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ULT Freezers in Drug Research and Development Laboratory

In the Drug Research and Development Laboratory, a ULT Freezer is a thermoelectric refrigeration system that takes advantage of the physical property of natural convection to cool or heat a liquid in vacuum. ULT Freezer is used for storing various materials like drugs, chemicals and biological samples at low temperature. It can be deployed in Research & Development laboratories, pharmaceutical companies manufacturing research and development leading to new product development and launches, law verification as well as drug manufacturing facilities. To know more visit here: https://www.nebiolab.com/how-to-use-ultra-low-temperature-ult-freezers-in-drug-rd-laboratory/

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Liquid Chromatography Mass Spectrometry Matrix Effect

The matrix effect in LC-MS is the correction of peak elution factors by adjusting the injection volume. In this way, a concentration peak may be corrected to represent a concentration equal across all the channels used to collect samples thus allowing for normalization of retention times among channels and improving efficiency.  In this Blog, we discuss what is liquid chromatography mass spectrometry matrix effect and how to reduce it. Visit now! https://www.nebiolab.com/what-are-matrix-effect-in-liquid-chromatography-mass-spectrometry/

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An Overview of Bioavailability and Bioequivalence in Drug Development

A drug's bioavailability and bioequivalence determine its effectiveness. In other words, if a product is not bioavailable, it cannot be absorbed by the body, and if it is not bioequivalent, the inactive ingredients are processed by the body for a longer period of time than intended.

Two key concepts in drug development are bioavailability and bioequivalence. The rate and extent to which a drug reaches its intended site of action is referred to as bioavailability, whereas bioequivalence refers to the drug's efficacy (i.e., the same clinical effect) despite differences in dosage formulation or delivery vehicle.

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Pharmacokinetics Services: Why is it Important for Healthcare Providers?

In today’s healthcare environment, pharmacokinetics (PK) are a critical factor when dealing with drug efficacy and dosing adjustments. Our pharmacokinetics services will help you provide the best care to your patients by helping you understand how your medications work, how they're broken down in the body and why this is important for healthcare providers.

Pharmacokinetics (PK) are a branch of pharmacology that deals specifically with the transport, absorption, metabolism and elimination of drugs in the human body. The practice of PK involves determining the concentrations of different drugs within your body after they have been administered; this will help determine the correct dosage amount for healthy patients.

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Role Of Toxicology Studies In Drug Development Process

Toxicology studies are a key component of drug development. They aid in the understanding of potential adverse effects, mechanism of action and possibly finding a safer alternative for treatment. Studies ensure that new drugs are safe for patients and do not affect a person's health negatively.

Toxicology is an important part of the drug development process. It helps in providing information on the pharmacokinetics and absorption, how the drug will affect its target tissues or organs, whether it causes any adverse effects, etc. To know more visit here: https://www.nebiolab.com/toxicokinetics-tk-studies/

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Ultra-Low Temperature Freezers for Use in the Drug R&D Laboratory

Ultra-low temperature freezers (ULTs) are the preferred temperature control unit for use in the drug R&D laboratory. They have the ability to maintain a food or pharmaceutical sample at temperatures from −120°C to +20°C. This is not only clinically safe, but in many cases will produce better quality results due to better stability of samples found in ULT-specific associated products.

The temperature range of these freezing systems allow for slow cooling after incubation and cell culturing, which preserves cellular integrity prior to freezing and then room temperature storage until needed for workup and analysis.

To know more information visit here: https://www.nebiolab.com/how-to-use-ultra-low-temperature-ult-freezers-in-drug-rd-laboratory/

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Toxicology Studies Using IND - Enabled GLP

This guide provides an overview of toxicology studies that can be conducted by an independent contract research organization using IND-enabled Good Laboratory Practice (GLP) under an approved test registration. The Expert Panel for Toxicology Studies Using IND-Enabled GLP have drawn upon their experience and knowledge to develop guidance on the design, performance, and reporting of these types of studies.

A toxicology study using an IND-enabled Good Laboratory Practice (GLP) program can be complicated and confusing. In this guide we will explain the process step by step, and make things easier for you!

https://www.nebiolab.com/complete-guide-on-ind-enabling-toxicology-studies/

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Bioanalytical Laboratories: Understanding Good Laboratory Practices

Bioanalytical Laboratories: Understanding Good Laboratory Practices (GLP) is a unique three-day program that focuses on the requirements of good laboratory practices and how they impact quality and regulatory compliance. The course covers topics such as how to develop a GLP compliant laboratory, aspects of validation and acceptance testing, statistical methods and data interpretation in support of GLP studies, as well as a wide range of other important topics.

To know read more visit here: https://www.nebiolab.com/good-laboratory-practices-for-bioanalytical-laboratories/

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Cytotoxicity Assay - NEBioLab

"Based on cellular function and activity, in-vitro cytotoxicity and cell viability assays for drug discovery and fundamental research. "

·         Cytotoxicity assays are designed to assess the ability of specific drug compounds to destroy an organism's healthy cells.

·         Cytotoxic compounds can cause either accidental (necrosis) or programmed cell death (referred to as apoptosis).

·         Cytotoxicity assays are used to evaluate the safety profile of a drug candidate during the nonclinical and clinical research phases of drug discovery and development.

To know more us: https://www.nebiolab.com/cytotoxicity-testing-assay/

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Biochemical Assay  - NEBioLab

“In-vitro biochemical assay for detecting, quantifying, and studying the binding or activity of biomolecules such as enzymes. “

Analytical methods used to measure and quantify metabolic reactions and cellular processes such as cell signalling and apoptosis are known as biochemical assays.During drug discovery and development, biochemical assay development and analysis is used as a routine, dependable procedure to aid target characterization and provide a useful understanding of biomolecular functions. Read More visit us: https://www.nebiolab.com/biochemical-assays-development/