(Carbethoxymethyl)triphenylphosphonium bromide (CAS 1530-45-6)
Chemical Information
PropertyDetailsChemical Name(Carbethoxymethyl)triphenylphosphonium bromideCAS Number1530-45-6Molecular FormulaC22H22BrO2PMolecular Weight429.29 g/molAppearanceWhite to light yellow crystalline powderChemical ClassPhosphonium Salt
The compound is also referred to as (Ethoxycarbonylmethyl)triphenylphosphonium bromide in scientific literature and chemical catalogs.
Key Applications of (Carbethoxymethyl)triphenylphosphonium Bromide
1. Wittig Reactions in Organic Chemistry
One of the primary applications of (Carbethoxymethyl)triphenylphosphonium bromide is in Wittig olefination reactions. The reagent helps convert aldehydes and ketones into alkenes, making it essential for constructing carbon–carbon double bonds in synthetic chemistry.
2. Pharmaceutical Intermediate Manufacturing
The compound is widely used in pharmaceutical synthesis for producing active intermediates and specialty molecules. Its phosphonium functionality enables selective reactions that are valuable in medicinal chemistry and drug discovery programs.
3. Carbon–Carbon Bond Formation
C–C bond formation is a fundamental process in chemical synthesis, and this phosphonium salt plays a significant role in enabling efficient molecular assembly. Researchers frequently use it in multi-step synthesis pathways for fine chemicals and advanced intermediates.
4. Research and Development Applications
Chemical laboratories use this reagent in organic transformations, catalyst development, and specialty material research. Its high reactivity and compatibility with various substrates make it useful in experimental synthesis projects.
Advantages of Using This Phosphonium Salt
High efficiency in olefination reactions
Reliable performance in synthetic pathways
Suitable for pharmaceutical and fine chemical production
Stable crystalline form for laboratory handling
Effective reagent for advanced organic synthesis
These characteristics make the compound a preferred choice for researchers involved in synthetic and medicinal chemistry.
Handling and Storage
According to available safety data, (Carbethoxymethyl)triphenylphosphonium bromide should be stored in a cool, dry, and well-ventilated environment. Appropriate protective equipment such as gloves and eye protection is recommended during handling.
Conclusion
(Carbethoxymethyl)triphenylphosphonium bromide is a versatile and highly valuable phosphonium salt used in organic synthesis, Wittig reactions, pharmaceutical intermediate production, and carbon–carbon bond formation. Its importance in modern chemical research and industrial synthesis continues to grow due to its reliability, efficiency, and broad applicability in advanced molecular transformations.