
祝日 / Permanent Vacation

❣ Chile in a Photography ❣
taylor price
"I'm Dorothy Gale from Kansas"

Origami Around
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occasionally subtle

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Discoholic 🪩
Monterey Bay Aquarium
Alisa U Zemlji Chuda
Acquired Stardust

JBB: An Artblog!

shark vs the universe
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Aqua Utopia|海の底で記憶を紡ぐ
tumblr dot com

#extradirty
2025 on Tumblr: Trends That Defined the Year
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@summerendroll
awww the like button turns into a rainbow when you press it! that's so cute...hey staff what's with all the trans women you keep nuking?
i think we should be ridiculing them more for this. you don't get to try and go all "queer website" when your staff likes to go on nuking sprees targeting the trans fem users
I get that sex and drugs are fun but even im like. at least have a 3rd thing. at least one more hobby. you can have a 3rd hobby. this isnt a purity thing this is a some of u are fucking boring thing.
rock & roll
girl i just walked into that one like a coyote with a painted tunnel
the most valueable skill a white leftist can ever learn is how to take an L with grace.
You gotta be able to take an L if your moral and ethical belief systems are to be capable of guiding you. Otherwise you just have an idealized self where you get really mad and scared when anyone points out it isn't actually you. How the fuck are you gonna walk the walk if you can't handle being told when you are not, in fact, actually walking it
you cannot just socially transition into being a good person you are going to have to settle for being a messy human being who has to try and fail and keep trying to get better like everyone else. yeah even when it's embarassing and sucks for you a lot.
Ya gotta learn to earnestly and honestly say "Oh shit, my bad."
And to then end the sentence there, not launch into a paragraph of explanation or panicked super-apology.
we gotta get back to torrent distribution, i just watched someone eat eight grand in bandwidth charges because they ran a direct-download piracy site with local file hosting through cloudflare. torrents were invented literally for this exact reason
torrents work like this
i have a file or folder on my pc that i want to share with other people. let's call it gayshit.mp3
unfortunately gayshit.mp3 is 750mb and im not paying for discord nitro so i need another way to send it
i put it into qbittorrent and it makes a torrent file. this is essentially a very small file that points to gayshit.mp3 so other computers can find it. kinda like a treasure map
i send this tiny file to my friend, who loads it into qbittorrent. their computer takes a moment to find mine over the vast expanse of cyberspace and then (as long as my pc is running and the file is still where it should be), it gets copied from my hard drive to theirs
this is the cool part: if somebody else loads that tiny file, they can download it from both of us. if i'm offline but my friend is on, the third person can still get it. this also means that if two people have separate halves of the file, they can download the other half from each other. as long as some combination of people have the pieces between them, they can all have the whole thing.
crucially this does not require a server!!! you can just upload the file to a few people and as long as they keep it, it's still accessible. as long as somebody, somewhere is still connected, it's available forever. the only way it goes away is if everybody disconnects from it.
please learn to torrent
An expert guide to get started using torrentsTorrents are one of the most popular forms of file sharing on the internet, accounting for over
always use qbittorrent, do not use bitorrent or utorrent.
Before I forget, please oh please use a VPN, your ISP will send you cease and desists for torrenting without some sort of proxy.
We love Mullvad (this is 5 bucks a month and can be paid for anon via either mailed cash or XMR) and Proton VPN (iirc they also do XMR??? but they also have a sale rn).
If you're into self hosting, check out Prowlarr to use as a search engine since some sites are genuinely just ass to use.
If you don't like qBittorrent, there's also Motrix (which is a great general download manager and suggested by Anna's Archive if you don't have a memership with them anyways) and Transmission if you prefer something simpler but doesn't also handle http(s).
And as always, if you have an internet plan with a very high/unlimited cap, keep seeding if you can, even a little always helps.
"why qbittorrent not the others?" prev tags; qBittorrent has been standard for a while and it works really well too. It has a bunch of features to automatically keep your torrents organized and going to the right places, supports I2P, default tracker lists, etc etc. All around it's the best client.
Oh, This is Gonna Hurt! Jack-O Valentine from Guilty Gear
i stg i’m still drawing regularly umm i’ve been watching akane banashi each week it’s so charming
If this page suddenly goes silent one day, know that my brother Samer didn’t make it. I will never forget those who saw him suffering from severe bombing injuries, lacking his vital medications, yet chose silence and kept scrolling.
I feel completely shattered and deeply ashamed begging strangers for help every single day. This endless nightmare has stripped us of everything, forcing me to sacrifice even my own dignity just to keep my brother and my family alive.
I want nothing from this world except to see Samer healthy and free of pain, and to save my family from this slow death. Please donate so we can afford his essential psychiatric and medical treatments before it’s too late.
Please Please donate GoFundMe
Thank you, Maryam Ather, for the first donation! 🤍 I swear these donations are our only way out. Please keep supporting us to save my brother Samer.
#75 Gazavetters and #171 PaliLiberation
i love explaining the etymology of the word "rickroll" because the story starts with "ok, so at one point 4chan applied a filter to everyone's posts that changed the word egg to duck"
grandfather....
numb hands
The fact that one of these moves is significantly more difficult for me than the other two at least tells me which nerve is probably the most fucked up
hi trans kiwis and friends. if you haven't seen the news, they're trying to pass a frankly insidious bill in aotearoa to define the terms 'man' and 'woman' based on biological sex. this unsurprisingly reflects a lot of similar cruel efforts happening overseas at the moment. IT HASN'T PASSED YET, but I figured I should speak up about it because this is happening as we speak.
(screenshot from the linked RNZ article)
it seems very fucking bleak!!!! please don't lose hope! it hasn't passed yet and a lot of the shoddy bills suggested by the coalition have been shot down already. it's still worth knowing about. you don't have to share this post if you don't want to. I just know that a lot of my followers are kiwi. if there are any updates as to what we can do to push back against this, I'll make a relevant addition. kia kaha, okay? love you all.
UPDATE: you can now very quickly and very easily submit a comment on the bill! these will be counted and considered in parliament.
it took me less than three minutes, and that's only because I wrote a whole paragraphs on why this is a stupid idea. all you really need to put is "don't pass this bill" if you want. it'll only take 30 seconds.
if you're able to and you want to, please consider reblogging! the more reach this gets, the better. thank you all so much [:
sorry i never replied. everyday is blending together and i'm losing sense of time
developing a new realm of “In my perfect FEA run, these would be the pairings” in 2026 is so funny. fea is what made really made me begin my life as a killjoy feminist bitch and yuri warrior so i suppose its only fitting to be coming back to finally play with the gay hack but i keep experimenting with pairings and restarting its terrible
i will also say that your doctor should absolutely tell you about possible side effects and interactions of medications they're prescribing to you! and also, pharmacies are obligated to provide you with this literature upon request, if they don't already give it to you with the medication itself. its always a good idea to ask for that literature when picking up a new med, and to read it through really thoroughly! that of course won't give you the kind of information like individual people sharing their experiences here will give you, but it is a good starting point for any medication. if you look at the wikipedia page for the medication you will also find information like the mechanism of action (if known,) the class the drug is in (which will give you information about things like abilify being an atypical antipsychotic,) and the half-life of the drug in your system. you can find out what waste filtration system the med is filtered thru (kidneys or liver*) and also stuff about crossing the blood-brain barrier, both of which are also REALLY useful things to know
these are all really good and important things to be aware of and I recommend gathering that info for any new meds. i don't say this to like, blame people who were not given this info by their doctors and who took meds without being given this information, but rather to give people resources for being more in control of their own medical treatment going forward 💜
*this was really crucial to know when my dad was dying bc his kidneys were overtaxed by all the medication that was being thrown at them and we ended up having to mess with the timing of his pain medication pretty carefully to avoid the meds building up in his system. each individual med wasn't the issue, it was the NUMBER of medications that the kidneys were being expected to handle -- in his case, ibuprofen was one of them; over the counter meds absolutely count towards this lol. knowing which OTC meds are filtered by the liver (acetaminophen) and which by the kidneys (ibuprofen) can really help you when calculating how much of each kind is safe to have at the same time.
hey! now that i'm on desktop, i wanted to add information about something i think should honestly be required to explain to "polypharmacy patients" (anyone who's taking multiple medications): cytochrome p450, or CYP450 for short.
CYP450 is a family of enzymes in humans. enzymes are chemicals that speed up chemical reactions; in this case, in our bodies, CYP450 enzymes process the vast majority of currently available medications. because of that, they're responsible for most drug interactions.
different substances - including medications, supplements, and even foods - can affect the CYP enzymes in different ways.
a CYP inhibitor blocks the CYP enzymes from working to process the medication. that means you can end up with more of the medication in your body than you expect. that can cause mild, moderate, or severe side effects. good examples of CYP inhibitors are St. John's wort, grapefruit, and isoniazid (a tuberculosis medication).
a CYP inducer encourages the CYP enzymes to work faster. that means you can end up with less of the medication in your body than you expect. that medication may not work as well. this can be especially dangerous in cases where, for example, you're suppressing a dangerous effect (like autoimmunity or transplant rejection). some examples of CYP inducers are insulin, tobacco, prednisone, and in some cases, St. John's wort again.
a CYP substrate is just a substance/medication that is affected by an inhibitor or inducer. birth control is a very common substrate, and its effectiveness is affected by many medications.
each substrate is related to a different family of CYP enzymes, like CYP3A4 or CYP2D6. each one responds to different inhibitors and inducers.
you can see why they often don't tell patients this stuff: It is complicated. this is pharmacokinetics! it's difficult stuff. but i really, really believe it's important. knowing how your medications affect each other can save your life. doctors and pharmacists often do not check medication interactions. sometimes it really is up to us to understand what we're putting in our bodies.
at the very least, i urge you to check drug interactions with the drugs.com interaction checker. this checker automates some of the work of cross-referencing CYP relationships. if you have an account, you can save your drug list and cross-check all of your meds at the same time. keep in mind that not all "severe" interactions will necessarily apply to you; i recommend reading the "for professionals" version of the warning to make informed decisions about whether or not you want to be concerned. (this is also something you can discuss with a good doctor if you have the good fortune to have one.)
but, if you have the capacity, at a certain number of medications (i am taking 20+) it really is worth getting to know how they interact with CYP enzymes, what effects you might need to be watching out for (more intense effects from a higher concentration of medication? less intense effects as the medication can't attain high enough concentrations to work as it normally does?), and what meds might be the culprits of new problems as you add more medications.
to cross-check CYP relationships directly, i recommend the flockhart table. search for a medication (ctrl+f helps) and you can see all its documented CYP relationships. (they also have a mobile friendly version, but i find it slightly harder to interpret.)
here's how i do it.
start with a medication or substance. let's say i'm about to start celecoxib (Celebrex), a non-steroidal anti-inflammatory drug (NSAID). on the flockhart table, it's listed as an inhibitor of CYP2D6. (ctrl+f is helpful here.)
think through what the words mean. it's an inhibitor, so it makes the enzymes not work as well. it might increase blood levels of medications that are processed by CYP2D6.
what medications are processed with that enzyme? the flockhart table lists them if you click on the name of the medication you're curious about. CYP2D6 substrates include amitriptyline (Elavil), aripiprazole (Abilify), atomoxetine (Strattera), duloxetine (Cymbalta), oxycodone (Oxycontin), and propranolol, among others.
what effects do i need to be watching for based on the affected medications? for an inhibitor, we're looking for stronger effects; for an inducer, we're looking for weaker effects. let's say i take oxycodone daily. i want to keep an eye on the way i feel when i take oxycodone. am i feeling "higher" than usual? am i feeling dazed or dizzy or numb? or let's say i take propranolol. am i feeling dizzier or more lightheaded? am i having nightmares that i wasn't before?
here's another example. what if i want to check for a substance that might not be listed on the flockhart table? grapefruit is a good example.
wikipedia is actually a great source for this (though in some cases i recommend just searching "[substance] CYP" and seeing what pops up).
head to the list of CYP450 modulators on wikipedia. ctrl+f finds three instances of grapefruit: naringenin (a CYP1A1 inhibitor), generic 'flavonoids' (inhibiting CYP2A6), and bergamottin (a powerful CYP3A4 inhibitor).
think through what the words mean. any substrate medications processed by 1A1, 2A6, or 3A4 enzymes might be dangerously increased in my bloodstream if i consume grapefruit (or anything containing those substances; earl grey tea actually contains bergamottin, too!)
what medications are processed with those enzymes? this i can check on the flockhart table, or i can stay on wikipedia. atorvastatin - a cholesterol medication - is a substrate of 3A4. so is diazepam (Valium). valproic acid, an anti-seizure medication, is a substrate of 2A6. i'm having more trouble finding substrates of 1A1. it's not listed on the flockhart table. there is a paper published that mentions theophylline (an asthma medication) and difloxacine (a fluoroquinolone antibiotic).
what effects do i need to be watching for based on the affected medications? at a glance here, i'd be worried about having too much valium or valproic acid in my system (if i took those meds) - those could have pretty serious effects on my central nervous system. likewise, having too much of that fluoroquinolone antibiotic (if i took it - and i wouldn't, because if you have hEDS you should not take fluoroquinolones unless it's a matter of life or death!) could increase my risk for serious musculoskeletal side effects like tendon rupture. it could also disrupt my bacterial microbiome.
the physician who created the flockhart table, the late dr. david flockhart, was an exemplary physician who truly, truly cared about patients - a rare treasure. everyone's CYP-related genes are different, and it affects the way we respond to medication. we know that, just as we know that CYP relationships can cause serious and harmful drug interactions. but we don't put it into clinical practice. dr. flockhart wanted to change that, and he did pave the way towards that future. we're not there yet. but i do recommend his table.
i hate that this is not something that is widely taught and widely understood. i hate that we have this knowledge about how people metabolize drugs and how drugs work with each other and we often just do not talk about it at all. i hate that i was not instructed on the risks of taking clonazepam (a benzodiazepine, in the same class as Valium) and hydrocodone (Vicodin, an opioid) simultaneously. i experienced central nervous system depression - difficulty breathing, dizziness, confusion, fatigue - multiple times as a teenager before i figured out that i shouldn't take them close together. needless to say, mixing those two drug classes can be extremely dangerous. i got lucky and just felt awful. but at certain doses or under certain circumstances, taking those two simultaneously could kill someone. Does kill people, in fact!
a responsible doctor - one of my favorite doctors! - prescribed me those medications. he just wasn't thinking. it happens all the time.
we should not have to be doing all this work. but often doctors and pharmacists simply do not think about it. and the literature they hand out with medications, while helpful, is not going to cover all possible interactions, especially for polypharmacy patients or people on unusual medications.
likewise, you should know what medications interact with your conditions - like i mentioned fluoroquinolones and hEDS earlier. or how morphine tends to activate mast cells. that's something i can't cover here, though.
i know this is a lot, and i know not everyone has had the opportunity to acquire medical literacy skills so they can interpret all of this information. my inbox is always open to medical questions (i am not a doctor + i do not know your medical history but i can provide explanations and sources and explain jargon) if you are trying to figure something out and just can't. i hope that this explanation helps someone to better understand what is going on in their body, or to make informed decisions about starting or stopping a medication.
this is so so helpfully written and such a great resource, thank you so much for adding it!
the nameless monster ⚫️🔴
Palestinian children were prevented from going to school by razor wire and israeli soldiers — so they sat down and studied right in front of them (via AndreyX)
11 year old Huda, April 26, 2026, via CNN
god i hate how normalized diet culture and shit like bmi and calories are. bmi is based on eugenics. calories are a measurement of how much energy something gives u and not at all of how much weight or fat ull gain. diets have been proven to be harmful and ultimately unhelpful in actually losing weight. fatness has been largely proven to not be inherently unhealthy and doesnt inherently cause health issues.
if anyone has more good links to add on then please do and if anyone knows more on this stuff than me then dont hesitate to correct me!
FOOD IS GOOD. FOOD IS GOOD. FOOD IS GOOD!! if you’re eating, ever, and even/especially if it’s hard, know that i am personally SO SO proud of you
The BMI was invented by Adolphe Quetelet, the 19th century statistician who invented phrenologist anthropometry. He wasn’t just a eugenicist, he was one of the founding fathers of racist pseudoscience. Please do not listen to anything he has to say about your body.
“And get this: While epidemiologists use BMI to calculate national obesity rates (nearly 35 percent for adults and 18 percent for kids), the distinctions can be arbitrary. In 1998, the National Institutes of Health lowered the overweight threshold from 27.8 to 25—branding roughly 29 million Americans as fat overnight—to match international guidelines. But critics noted that those guidelines were drafted in part by the International Obesity Task Force, whose two principal funders were companies making weight loss drugs.”
Source: https://www.motherjones.com/politics/2014/08/why-bmi-big-fat-scam/
Body mass index is used to sell weight loss drugs, set insurance premiums, and counsel patients. There's just one little problem.
I always thought everyone knew this by like the early 2000s but instead I see more people than ever believing this stuff is real medical science
Man if y'all folks up thread thought this situation was bad back in 2021 (as I did too) you won’t BELIEVE what the 2026 cultural convo on these topics is like.