Artist's rendering of liver in the body. (Credit: © Sebastian Kaulitzki / Fotolia)
MIT engineer Sangeeta Bhatia and her team are on their way to discovering new methods to grow liver cells outside of the body for eventual human transplants. The most notable segments of the article include:
They have identified a dozen chemical compounds that can help liver cells not only maintain their normal function while grown in a lab dish, but also multiply to produce new tissue.
This accomplishment was due to her innovative idea to combine liver cells with mouse fibroblast, which temporarily maintain normal liver-cell function after those cells are removed from the body. This allowed the team to identify the proper compounds to help maintain the liver's 4 main categorical functions (rug detoxification, energy metabolism, protein synthesis and bile production)
They were able to create liver cells that can fully mature outside the body by testing them in liver cells generated from induced pluripotent stem cells (iPSCs).
The aspect of artificial organs seems nefariously futuristic, but I believe that its main goal to save innumerable lives with liver transplants is quite an amazing feat. There are however, more future projects in place to further comprehend how to successfully build a liver from these artificial cells.