#biohacking for longevity

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Biohacking for Longevity: Science-Backed Habits for 2026

We’ve all heard the old cliché that age is just a number. But let’s be honest: when you wake up with a mysterious back tweak because you slept “wrong,” that number feels incredibly real. For years, the medical world focused on lifespan—the total years you’re breathing. But at Healthy Wayz, we’re obsessed with a different metric: healthspan. Think of it this way: what’s the point of reaching 95…

Biohacking for Longevity: Science-Backed Habits for 2026

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Lecture on Energy Formula by Shawn Wells

Resilience is a state of being tougher and “antifragile” – being “harder to kill” in terms of healthspan. Historically, we know that lifespan is how long you live, but healthspan is how long you live without disease.

Moreover, there is an allostatic load which is the size of your stress bucket. We have a much smaller bucket than we used to have, and it's our capacity for stress. It's how much stress we can take on in that bucket and when we do things like hormesis, we can have more stress. We have a bigger capacity for stress. We have a more significant allostatic load.

The room for stress growth and more training workroom for your relationships, but when that allostatic load bucket's overflowing, that's when you run into distress. All that stress is overflowing, and you're in states of distress.

Shawn Wells, Nutritional biochemist and Expert on Health Optimization, shares his Top 12 Longevity Hacks from the ENERGY Formula for us to be resilient human beings.

Shawn reveals his top longevity hacks, including Experiment, Nutrition, Exercise, Routines, Growth, and Your Tribe, for you to biohacking your health.

“The number one supplement for biohackers is L-BAIBA (β-aminoisobutyric acid). It releases during exercising and increases energy expenditure (i.e., metabolic rate) by activating the β-oxidation pathway of hepatic fatty acids.

“L-BAIBA triggers the browning of white adipose tissue, which can lead to increased metabolic rate and fat oxidation. Overall, L-BAIBA improves insulin sensitivity, may help reduce body fat and seems to exert anti-inflammatory effects. The recommended dose is 750 - 2000mg (e.g., before exercise and/or before cold exposure).”

The next one is Grains of Paradise (GP) ー an ancient spice in the ginger family.

It activates brown adipose tissue (BAT). Unlike white adipose tissue (e.g., subcutaneous fat), which stores calories as fat, BAT is mitochondrial dense and metabolically active, burning calories to generate heat.

Grains of Paradise is a good choice for body composition goals and optimizing metabolic health. One study showed an increase of, on average, 100 more calories burned daily with GP supplementation.

Shawn underlines that it is important to use  Grains of Paradise extract with all four metabolism-enhancing bioactive compounds: 6-Paradol, 6-Gingerdione, 6-Shogaol, and 6-Gingerol.

The recommended dose is 40 - 80mg twice daily, combined with cold plunges or cryo.

The next supplement is Dihydroberberine (DHB) ー Shawn’s favorite compound for anti-aging. It is often referred to as a glucose disposal agent.

Berberine has been used in Chinese and Ayurvedic medicine for decades to help lower blood sugar. “Berberine  is preventing blood sugar damage like Advanced glycation end products (AGEs) that actually aid you, and it's going to improve anti-inflammatory dyslipidemia, but this is probably one of the most powerful methods of anti-aging that we know of right now.”

Berberine offers powerful support for glycation (i.e., helps reduce formation of advanced glycation end-products) and healthy lipid metabolism (e.g., cholesterol, triglycerides).

Berberine shares some effects with Metformin. Both of these drugs support the body's repair function and therefore play a crucial role in biohacking for longevity. “In a 90-day study, Metformin was shown to improve longevity by as much as two years with biomarkers. Obviously, we can't do lifetime models in humans, but it's been shown to do similar things in animal models, so as far as we know, there's a 3000-person study going on right now with metformin. It’s a powerful anti-aging drug. However, I prefer berberine because it's been shown to be more powerful, and it’s natural.”

However, animal studies demonstrate DHB is four times more effective than berberine at reducing body fat and improving glucose tolerance.

The recommended dose is 150mg twice daily.

Nicotinamide Adenine Dinucleotide or simply NAD, is the supplement that takes an important role in energy metabolism and helps certain enzymes involved in vital cellular functions, such as cellular repair and cellular defense.

NAD is the key cellular fuel for the sirtuins, the gatekeepers of key longevity and resilience pathways. Chronic inflammation causes a reduction in NAD levels, as does excess alcohol consumption, excess UV exposure, inadequate sleep, poor diet, viral infections, and a sedentary lifestyle.

 As we age, our bodies make less NAD, and what we do make disappears faster than when we were young; for example, by the time we hit 50, NAD levels are half of what they were in our youth.

The recommended dose is 250 - 2,000mg per day.

BiohackingCongress's Team is thankful to Shawn Wells for joining our biohacking congress and giving an inspiring lecture for biohacking health.

Watch Shawn’s lecture and get a helpful list of 12 Top Biohacking Supplements and 12 Top Biohacks to follow daily! Get a BiohackingCongress year-long subscription now. Follow this link.

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Based on the lecture by Shawn Wells.