#c. diff. research community

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Researchers Find Ultrasensitive Stool Toxin Detection and Concentration Correlated with Severe Baseline In Hospitalized Patients With C. difficile Infection

Researchers Find Ultrasensitive Stool Toxin Detection and Concentration Correlated with Severe Baseline In Hospitalized Patients With C. difficile Infection

Ultrasensitive and quantitative toxin measurement correlates with baseline severity, severe outcomes, and recurrence among hospitalized patients with Clostridioides difficile infection Carolyn D Alonso, Ciarán P Kelly, Kevin W Garey, Anne J Gonzales-Luna, David Williams, Kaitlyn Daugherty, Christine Cuddemi, Javier Villafuerte-Gálvez, Nicole C White, Xinhua Chen, Hua Xu, Rebecca Sprague, Caitlin…

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Vanderbilt University Medical Center Scientists Demonstrated C. diff. Exposed To Heme Increases Expression of a Protein System Not Previously Studied

Vanderbilt University Medical Center Scientists Demonstrated C. diff. Exposed To Heme Increases Expression of a Protein System Not Previously Studied

    Vanderbilt University Medical Center scientists have identified a C. diff protein system that senses and captures heme (part of hemoglobin) to build a protective shield that fends off threats from our immune system and antibiotics. The findings, reported in the journal Cell Host & Microbe, reveal a unique mechanism for C. diff survival in the human gut and suggest novel strategies for…

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Biologists Develop Models to Aid Development of Novel Therapies to Fight Clostridioides difficile (C. diff.) Pathogen

Biologists Develop Models to Aid Development of Novel Therapies to Fight Clostridioides difficile (C. diff.) Pathogen

The Clostridium difficile pathogen takes its name from the French word for “difficult.” A bacterium that is known to cause symptoms ranging from diarrhea to life-threatening colon damage,

      C. difficile is part of a growing epidemic of concern for the elderly and patients on antibiotics.

Outbreaks of C. difficile-infected cases have progressively increased in Western countries, with 29,000…

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Researchers Report Bezlotoxumab Treatment Reduced C. diff. Recurrence in Cancer Patients

Researchers Report Bezlotoxumab Treatment Reduced C. diff. Recurrence in Cancer Patients

Abstract Background

The incidence of Clostridioides difficile infection (CDI) is reportedly higher and the cure rate lower in individuals with cancer versus those without cancer. An exploratory post-hoc analysis of the MODIFY I/II trials (NCT01241552/NCT01513239) investigated how bezlotoxumab affected the rate of CDI-related outcomes in participants with cancer.

Methods

Participants…

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Researchers From North Carolina State University Find That Antibiotics Give C.diff. Nutrient-Rich Environment

Researchers From North Carolina State University Find That Antibiotics Give C.diff. Nutrient-Rich Environment

Using a mouse model, researchers from North Carolina State University have found that antibiotic use creates a “banquet” for Clostridium difficile (C. diff), by altering the native gut bacteria that would normally compete with C. diff for nutrients. The findings could lead to the development of probiotics and other strategies for preventing C. diff infection.

C. diffis a harmful bacterium that…

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Norman B. Javitt, M.D. Is Welcomed As a Member Of the C Diff Foundation, R & D Committee

Norman B. Javitt, M.D. Is Welcomed As a Member Of the C Diff Foundation, R & D Committee

We are pleased to welcome Norman B. Javitt, M.D. to the C Diff Foundation.

Dr. Javitt has an extensive professional career in health care.  New York University Medical Center: Instructor, then Assistant Professor Medicine where his career was devoted mostly to research in liver disease, specifically in inborn errors of cholesterol metabolism affecting newborns, and to teaching medical students.

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Vitality Biopharma Researchers Unlock the Use of Cannabinoid Compounds For the Treatment of Microbes Including Clostridium difficile

Vitality Biopharma Researchers Unlock the Use of Cannabinoid Compounds For the Treatment of Microbes Including Clostridium difficile

Vitality Biopharma , a corporation dedicated to the development of cannabinoid prodrug pharmaceuticals, and to unlocking the power of cannabinoids for the treatment of serious neurological and inflammatory disorders, today announced that it has obtained positive results demonstrating antimicrobial activity of cannabinoids and filed for patent protection on the use of cannabinoid compounds for…

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Clostridium difficile Research Suggests That Positively Selected Sites In the Surface Layer Proteins May Play A Role In Driving the Emergence of Hyper-virulent Strains

Clostridium difficile Research Suggests That Positively Selected Sites In the Surface Layer Proteins May Play A Role In Driving the Emergence of Hyper-virulent Strains

Mark Lynch,

Thomas A. Walsh,

Izabela Marszalowska,

Andrew E. Webb,

Micheál MacAogain,

Thomas R. Rogers,

Henry Windle,

Dermot Kelleher,

Mary J. O’Connell†Email author and

Christine E. Loscher†

To Read Abstract/Article In Its Entirety Please Click On the Following Link:

https://bmcevolbiol.biomedcentral.com/articles/10.1186/s12862-017-0937-8

  Abstract Background

Clostridium difficileis a…

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