#chenodeoxycholic acid

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Interaction of chenodeoxycholic acid with cholesterol in a model system studied by spin label probe method

Interaction of cholesterol which is an essential structural component of animal cell membranes that is required to establish proper membrane permeability and fluidity and the bile chenodeoxycholic acid which significantly increased serum total cholesterol, and high-density-lipoprotein (HDL) cholesterol, and dissolves gallstones appears to be one of pivotal problem of biomedical gastroenterology. The methods of spin labels and spin probes have been proved to be power tools for solving structural and dynamical problems of chemistry and biology on molecular level. In present work the method of spin probes was used for investigation of quantitative interaction of cholesterol and chenodeoxycholic acid in ethanol possessing dielectric properties similar to ones of biological membranes. Using Electron Spin Resonance of nitroxide spin probe, it was shown that in the ethanol solution cholesterol molecules form aggregates, modeling a gallstone, which effectively bound chenodeoxycholic acid. The developed method can be used for study relationships between cholesterol and chenodeoxycholic acid in the in human blood, high-density-lipoproteins and gallstones.

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Chenodeoxycholic acid Drug

Medical information for Chenodeoxycholic acid on Pediatric Oncall including Mechanism, Indication, Contraindications, Dosing, Adverse Effect, Interaction, Hepatic Dose.

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Interaction of cholesterol which is an essential structural component of animal cell membranes that is required to establish proper membrane permeability and fluidity and the bile chenodeoxycholic acid which significantly increased serum total cholesterol, and high-density-lipoprotein (HDL) cholesterol, and dissolves gallstones appears to be one of pivotal problem of biomedical gastroenterology. The methods of spin labels and spin probes have been proved to be power tools for solving structural and dynamical problems of chemistry and biology on molecular level. In present work the method of spin probes was used for investigation of quantitative interaction of cholesterol and chenodeoxycholic acid in ethanol possessing dielectric properties similar to ones of biological membranes. Using Electron Spin Resonance of nitroxide spin probe, it was shown that in the ethanol solution cholesterol molecules form aggregates, modeling a gallstone, which effectively bound chenodeoxycholic acid. The developed method can be used for study relationships between cholesterol and chenodeoxycholic acid in the in human blood, high-density-lipoproteins and gallstones.

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Chenodeoxycholic acid (also known as chenodesoxycholic acid, chenocholic acid and 3?,7?-dihydroxy-5?-cholan-24-oic acid) is a bile acid. It occurs as a white crystalline substance insoluble in water but soluble in alcohol and acetic acid, with melting point at 165-167 ?C. Salts of this carboxylic acid are called chenodeoxycholates. Chenodeoxycholic acid is one of the main bile acids produced by the liver. Chenodeoxycholic acid and cholic acid are the two primary bile acids in humans. Some other mammals have muricholic acid or deoxycholic acid rather than chenodeoxycholic acid. Chenodeoxycholic acid is synthesized in the liver from cholesterol by a process which involves several enzymatic steps. Like other bile acids, it can be conjugated in the liver with taurine or glycine, forming taurochenodeoxycholate or glycochenodeoxycholate. Conjugation results in a lower pKa. This means the conjugated bile acids are ionized at the usual pH in the intestine and will stay in the gastrointestinal tract until reaching the ileum where most will be reabsorbed. Bile acids form micelles which facilitate lipid digestion. After absorption, they are taken up by the liver and resecreted, so undergoing an enterohepatic circulation. Unabsorbed chenodeoxycholic acid can be metabolised by bacteria in the colon to form the secondary bile acid known as lithocholic acid. Choendeoxycholic acid is the most potent natural bile acid at stimulating the nuclear bile acid receptor, farnesoid X receptor (FXR). The transcription of many genes is activated by FXR. This report provides detailed analysis of worldwide markets for Chenodeoxycholic Acid from 2011-2015 and provides extensive market forecasts 2016-2021 by region/country and subsectors. It covers the key technological and market trends in the Chenodeoxycholic Acid market and further lays out an analysis of the factors influencing the supply/demand for Chenodeoxycholic Acid, and the opportunities/challenges faced by industry participants. It also acts as an essential tool to companies active across the value chain and to the new entrants by enabling them to capitalize the opportunities and develop business strategies. GCC's report, Global Chenodeoxycholic Acid Market Outlook 2016-2021, has been prepared based on the synthesis, analysis, and interpretation of information about the global Chenodeoxycholic Acid market collected from specialized sources. The report covers key technological developments in the recent times and profiles leading players in the market and analyzes their key strategies. The competitive landscape section of the report provides a clear insight into the market share analysis of key industry players. The major players in the global Chenodeoxycholic Acid market are Prodotti Chimici e Alimentari (Italy), ICE (Italy), Hengchanglong Pharmaceutical (China), Suzhou Tianlu (China), Zhongshan Belling (China), Anhui Kebao (China), among others. The report provides separate comprehensive analytics for the North America, Europe, Asia-Pacific, Middle East and Africa and Rest of World. In this sector, global competitive landscape and supply/demand pattern of Chenodeoxycholic Acid industry has been provided.

For overview analysis, the report introduces Global Chenodeoxycholic Acid basic information including definition, classification, application, industry chain structure, industry overview, Development Status and news analysis, etc.

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Interaction of cholesterol which is an essential structural component of animal cell membranes that is required to establish proper membrane permeability and fluidity and the bile chenodeoxycholic acid which significantly increased serum total cholesterol, and high-density-lipoprotein (HDL) cholesterol, and dissolves gallstones appears to be one of pivotal problem of biomedical gastroenterology. The methods of spin labels and spin probes have been proved to be power tools for solving structural and dynamical problems of chemistry and biology on molecular level. In present work the method of spin probes was used for investigation of quantitative interaction of cholesterol and chenodeoxycholic acid in ethanol possessing dielectric properties similar to ones of biological membranes. Using Electron Spin Resonance of nitroxide spin probe, it was shown that in the ethanol solution cholesterol molecules form aggregates, modeling a gallstone, which effectively bound chenodeoxycholic acid. The developed method can be used for study relationships between cholesterol and chenodeoxycholic acid in the in human blood, high-density-lipoproteins and gallstones.

Volume 4, Number 1, January 2014 – International Journal of Biomolecules and Biomedicine (IJBB)

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Interaction of chenodeoxycholic acid with cholesterol in a model system studied by spin label probe method

Interaction of cholesterol which is an essential structural component of animal cell membranes that is required to establish proper membrane permeability and fluidity and the bile chenodeoxycholic acid which significantly increased serum total cholesterol, and high-density-lipoprotein (HDL) cholesterol, and dissolves gallstones appears to be one of pivotal problem of biomedical gastroenterology. The methods of spin labels and spin probes have been proved to be power tools for solving structural and dynamical problems of chemistry and biology on molecular level. In present work the method of spin probes was used for investigation of quantitative interaction of cholesterol and chenodeoxycholic acid in ethanol possessing dielectric properties similar to ones of biological membranes. Using Electron Spin Resonance of nitroxide spin probe, it was shown that in the ethanol solution cholesterol molecules form aggregates, modeling a gallstone, which effectively bound chenodeoxycholic acid. The developed method can be used for study relationships between cholesterol and chenodeoxycholic acid in the in human blood, high-density-lipoproteins and gallstones.

Volume 4, Number 1, January 2014 –International Journal of Biomolecules and Biomedicine (IJBB)