#chenyang wang

[dr-afsaeed]

Programming Mn(II) coordination in self-assembling peptides amplifies mtDNA-driven STING signaling for potent antitumor immunity - Research

Activation of the cGAS-STING pathway is a powerful antitumor strategy, but its therapeutic performance is often constrained by insufficient cytosolic DNA cues. Here, we report a bioinspired metallopeptide nanoassembly, RKLAHE-Mn, formed through dynamic N,O-bidentate coordination between Mn(II) and a programmable hexapeptide scaffold. By leveraging specific interactions between histidine and…