Jun 24
Spatial architecture of the melanoma immune niche reveals CORO1A as a functional hub for T cell cytotoxicity and immunotherapy synergy - Research
Background: Immune checkpoint blockade (ICB) often fails in cutaneous melanoma due to an incomplete understanding of the spatially organized tumor microenvironment (TME). This study aims to define the spatial architecture of the melanoma TME and identify key molecular regulators that determine anti-tumor immunity and ICB response. Methods: We employed an integrative analysis of single-cell and…
#Architecture#cell#CORO1A#cytotoxicity#doi:10.1186/s12967-026-08435-0#Functional#Haoxinai Wang#hub#Immune#immunotherapy#Lei Li#MEDLINE#Melanoma#National Center for Biotechnology Information#National Institutes of Health#National Library of Medicine#NCBI#niche#NIH#NLM#pmid:42337596#PubMed Abstract#research#Reveals#Shuai Zhang#Spatial#Synergy