#cryoelectron microscopy

[kamalkafir-blog]

Loss of FCoV-23 spike domain 0 enhances fusogenicity and entry kinetics

Cell lines The following cell lines used in this study were obtained from the American Type Culture Collection (ATCC): human epithelial embryo cells (HEK293T, CRL-3216), human lung carcinoma epithelial cells (A549, CRM-CCL-185), human lung adenocarcinoma epithelial cells (Calu3, HTB-55), African green monkey kidney cells (VeroE6, CRL-1586), rhesus monkey kidney cells (LLC-MK2, CCL-7), Syrian…

[kamalkafir-blog]

How short peptides dis***emble tau fibrils in Alzheimer’s disease

Low, K. J. Y., Venkatraman, A., Mehta, J. S. & Pervushin, K. Molecular mechanisms of amyloid disaggregation. J. Adv. Res. 36, 113–132 (2022). Article  CAS  PubMed  Google Scholar  Hou, K. et al. D-peptide-magnetic nanoparticles fragment tau fibrils and rescue behavioral deficits in a mouse model of Alzheimer’s disease. Sci. Adv. 10, eadl2991 (2024). Article  CAS  PubMed  PubMed Central  Google…

[kamalkafir-blog]

Structural insights into human Pol III transcription initiation in action

Arimbasseri, A. G. & Maraia, R. J. RNA polymerase III advances: structural and tRNA functional views. Trends Biochem. Sci. 41, 546–559 (2016). Article  CAS  PubMed  PubMed Central  Google Scholar  White, R. J. Transcription by RNA polymerase III: more complex than we thought. Nat. Rev. Genet. 12, 459–463 (2011). Article  CAS  PubMed  Google Scholar  Dumay-Odelot, H., Durrieu-Gaillard, S., El…

[kamalkafir-blog]

Effect of phosphorylation barcodes on arrestin binding to a chemokine receptor

Nobles, K. N. et al. Distinct phosphorylation sites on the β2-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin. Sci. Signal 4, ra51 (2011). Article  CAS  PubMed  PubMed Central  Google Scholar  Schafer, C. T., Chen, Q., Tesmer, J. J. G. & Handel, T. M. Atypical chemokine receptor 3 “senses” CXC chemokine receptor 4 activation through GPCR kinase…