Sep 5, 2025
Type A cholesterol-dependent cytolysins translocate to the <i>trans</i>-Golgi network for NLRP3 inflammasome activation - New Study
Nature Immunology, Published online: 05 September 2025; doi:10.1038/s41590-025-02277-6 Chen and colleagues show that type A cholesterol-dependent cytolysins, a group of bacteria pore-forming toxins, translocate to the trans-Golgi network to remodel it into a platform for NLRP3 activation. Summary Chen et al. reported in Nature Immunology that type A cholesterol-dependent cytolysins (CDCs),…