#nlrp3

[david-ojcius]

Inflammasome-mediated glucose limitation induces antibiotic tolerance in Staphylococcus aureus

Beam and Wagner et al., find that NLRP3 activation and subsequent increased host cell glycolysis drive the formation of antibiotic tolerant

• Staphylococcus aureus activates NLRP3 inflammasome in macrophages • NLRP3 activation --> depletion of glucose in mac cytoplasm • Reduced glucose --> antibiotic tolerance in S. aureus • Restoration of cytoplasmic glucose improves antibiotic efficacy

[david-ojcius]

Interactions between silica and titanium nanoparticles and oral and gastrointestinal epithelia: Consequences for inflammatory diseases and c

Engineered nanoparticles (NPs) composed of elements such as silica and titanium, smaller than 100 nm in diameter and their aggregates, are f

Interactions between silica and titanium nanoparticles and oral and gastrointestinal epithelia: Consequences for inflammatory diseases and cancer

[don-lichterman]

How the danger sensor NLRP3 lengthens itself like a thread -- ScienceDaily

How the danger sensor NLRP3 lengthens itself like a thread — ScienceDaily

Redness, swelling, pain — these are signs of inflammation. It serves to protect the body from pathogens or foreign substances. Researchers from the Universities of Bonn and Cologne were able to show that inflammatory reactions of an important sensor protein proceed in a specific spatial direction. This finding has the potential to conceivably stop inflammation at the “growing end,” and thus bring…

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[ricercamix]

Un nuovo approccio per la cura delle malattie cardiovascolari

Un nuovo approccio per la cura delle malattie cardiovascolari

Eccomi di nuovo a raccontarvi quello che mi affascina del nuovo “pezzettino” di mondo, il vasto mondo della ricerca scientifica, che sto scoprendo in questo ultimo periodo. Ho deciso infatti di svolgere un periodo del mio dottorato all’estero, e più precisamente al Cardiovascular Epidemiological Unit (CEU) nel dipartimento di Public Health and Primary Care (PHPC) dell’University of Cambridge, sot…

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[themicronut]

Cholesterol Crystals and oxidized LDL: How are those formed though??