Deformities and Derangements
The original World of Darkness' views on physical, mental, and other such disabilities and body types are rather toxic, relying on negative stereotypes and in some cases outright insulting takes.
However, there is always room to grow different things where the land is choked by weeds. Or so they say.
Derangements are mental and emotional flaws that affect the mind and psyche of the character. Deformities are physical, spiritual, and supernatural flaws that affect the body and supernatural aspects of the character.
Most commonly and notably, these two things are seen in Malkavians among the Kindred and Merus among the Changing Breeds due to their unique origins and lore, though any character can acquire or have these traits through character creation and game play.
All Malkavians have an innate derangement (a few of more than one) decided upon character creation. Merus also start with with a Deformity (which can include Derangements in this particular case). A number of players will inevitably pick ones based off the things they see in media or know of through social osmosis. While there is nothing wrong with that, there is sadly a great deal of misinformation, negative stereotypes, insulting caricatures, and other issues in a great many shows and their presentation and representations of these struggles.
While I do encourage representation and diversity amongst my players in all its forms, I also encourage them to understand the unique views and struggles of those Identities. Thus, even if they do not always become too much of a focus in any particular chronicle (depending on players and themes and such), these identites are still given the respect and gravitas they deserve with as much care and nauce as possible.
Now that that is said, I am well aware that even these word choices are....not ideal. Deranged has been used to harm those with mental impairments and Deformity has done much the same for those who do not match today's increasingly ridiculous standards of acceptable body types. I am using these words as the game does, but felt the need to acknowledge how their history has been used to harm people.
Should player ever express discomfort in the usage, I will make whatever efforts are needed to make them feel more comfortable, even if it means changing the usage of certain words.