Colace
Ingredient: Docusate sodium.
Dosage Form:
Colace Capsules: 500 mg or 100 mg.
Capsules: 250 mg (generic only).
Colace Clear Capsules: 50 mg (dye free).
Syrup: 60 mg per 15 mL (generic only).
FDA Indication/Dosages:
For the relief of occasional constipation and irregularity and in conditions in which maximum ease of passage of stools is desirable including abdominal hernia, severe hypertension, and cardiovascular disease: Adults: 50-200 mg daily. Expect results in 1-3 days after first dose (15 minutes after using the micro-enema).
Children 6-12: 40-120 mg daily.
Children 3-6: 20-60 mg daily.
Children under 3: 10-40 mg daily.
Give Colace liquid in half a glass of milk or fruit juice or in infant formula to mask bitter taste.
Pharmacology: Docusate is an anionic surfactant that affects the intestinal contents as well as decreases intestinal absorption of water and electrolytes. This results in softer stools.
Evaluation: Constipation can present itself as lower abdominal pain, anorexia, headache, abdominal distension, or the passing of hard, dry stools. Each patient will have their own definition of constipation and these definitions will vary greatly. The “normal” period between stools in individuals can range from 3 stools a day to one stool every other day. The patient should be asked about recent bowel movements as well as normal diet and exercise routines. Many times, a high fiber diet with 2-3 liters of fluid intake per day will be sufficient to restore normal bowel habits. Stool softeners can be helpful in patients in which straining during a bowel movement is detrimental. This includes post-surgery, severe hypertension, or severe cardiovascular disease, and abdominal hernia.
Contraindications/Precautions: Do not use for more than 7 days unless directed to do so by a physician. Prolonged use may cause active liver disease. Rectal bleeding or failure to have a bowel movement after use may be signs of a serious condition – discontinue use and contact a physician. May increase the absorption of poorly absorbed drugs, especially danthron and mineral oil.
Adverse Effects: Rare, but may include bitter taste, throat irritation, and nausea from syrup and liquid forms.
Patient Consultation:
Ask if they have had any abdominal pain, nausea, or vomiting associated with the constipation.
Ask if anything has changed in their bowel habits or appearance.
Ask if they have tried increasing dietary fiber, fluid intake, or exercise to relieve constipation.
Notify a physician if rectal bleeding occurs.
Do not use for more than 7 days unless directed to do so by a physician.
