#granulosa

[slimlastforskolins]

Mouse pups born from eggs derived from the granulosa cells that surround oocytes -- ScienceDaily

Mouse pups born from eggs derived from the granulosa cells that surround oocytes — ScienceDaily

By introducing a chemical cocktail to granulosa cells, researchers in China induced the cells to transform into functional oocytes in mice. Once fertilized, these oocytes were then successfully able to produce healthy offspring, showing no differences from naturally bred mice. The chemical reprogramming method appears December 24 in the journal Cell Reports.

Ovarian follicles are the basic…

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[scientistkitty]

Notch Signalling and Granulosa Cells

I've studied Notch signalling a bit during my degree, though it was limited to how

it prevents differentiation to nerve cells. Considering it was such a brief example

in the unit, I never really thought how it would play a role in different tissues.

Notch signalling is used as a way to regulate transcription of genes involved in

not only differentiation, but also apoptosis and proliferation. The article I found

by  Zhang CP et al (2011) highlights how it can be used to control proliferation in

Granulosa cells during follicular development of the oocyte. An inhibitor to Notch

signalling, preventing the cleavage of the tail, was used, and following the

treatment, all proliferation stopped.

Finding articles that develop what I've only touched on in lectures make them all

the more interesting. And make the module more interesting too. Shame I've

already had that exam.

Zhang, C. P., Yang, J. L., Zhang, J., Li, L., Huang, L., Ji, S. Y., Hu, Z. Y., Gao, F. & Liu, Y. X. (2011). Notch Signaling Is Involved in Ovarian Follicle Development by Regulating Granulosa Cell Proliferation. Endocrinology.