Jun Ogawa : Research profile
Postbiotics: Novel gut microbiota-derived materials that promote our health and are useful as functional foods and pharmaceuticals (video 8m 44s)
Jun Ogawa
Professor, Laboratory of Fermentation Physiology and Applied Microbiology, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University
Professor Jun Ogawa covers the following areas of his research on gut microbiota.
Gut microbiota as a metabolic organ, and ‘postbiotics’ as novel materials promoting human health and useful as functional foods and pharmaceuticals.
Gut microbial food component metabolism
Lipid - Fatty acid
DNA/RNA – Nucleotide/Nucleoside
Protein – Amino acid (D-amino acid)
Polysaccharide - Sugars
Plant derived bio-active molecules – polyphenols, glucosinolates, urolithins, etc.
Function expression by gut microorganisms
Effects of bacterial cell components themselves
Function expression by interaction between microbial cell components (LPS, etc.) and host receptors (TLR, etc.)
Immunomodulation, etc.
Effect of fermentation product of microbes
Production of short-chain fatty acids by fermentation of dietary fiber (polysaccharides)
Metabolic control (anti-obesity) / anti-inflammatory action by acetic acid / propionic acid / butyric acid
Effects of microbial metabolic activity and metabolites (metabolites of food components, postbiotics)
Enhancement / suppression of host metabolism
Effects through metabolism not found in the host
Relevant publications by Professor Ogawa and his colleagues
Novel PUFA-saturation metabolism found in Lactobacillus plantarum
Ø Kishino, S. et al, Proc. Natl. Acad. Sci. USA, 110, 17808-17813 (2013)
Enhancing gut hormone secretion & anti-diabetic activity
Ø Goto J. et al, Biochem. Biophys. Res. Commun., 459, 597–603 (2015)
Kim M. et al, FASEB J., 31, 5036-5048 (2017)
Ø Yonejima Y., et al, Prog. Med., 37, 1105-1111 (2017)
Ø Miyamoto J., et al, Nat. Commun.10, 4007 (2019)
Hypolipidemic effect
Ø Nanthirudjanar T., et al, Lipids, 50, 1093-1102 (2015)
Anti-inflammatory and immune controlling effects
Ø Bergamo P,. et al, J. Funct. Foods, 11, 192-202 (2014)
Ø Ohue-Kitano R,. et al, FASEB J., 32, 304-318 (2018)
Intestinal and gingival epithelial barrier protection
Ø Miyamoto J. et al, J. Biol. Chem., 290, 2902–2918 (2015)
Ø Yamada M. et al., Sci. Rep., 8, 9008 (2018)
Anti-oxidative effects
Ø Furumoto H., et al, Toxicol. Appl. Pharmacol., 296, 1-9 (2016)
Anti Helicobacter pylori activity
Ø Matsui H., et al, Helicobacter, 22, e12430 (2017)
Gut microbiota confer host resistance to obesity by metabolizing dietary polyunsaturated fatty acids.
Ø Miyamoto J., et al, Nature Comm, 10:4007, 2019
Further information
http://www.hakko.kais.kyoto-u.ac.jp/English/member-E.html