HLA: A Factor in Developing IgE to Chemical Conjugates Chemicals can conjugate with cells in the body, and the body can develop IgE to that chemical-cell conjugate. . . There was an increased frequency of HLA-DR3 in workers exposed to acid anhydride who developed IgE to acid anhydride-albumin conjugates. (Young et al.) (HLA, among other things they do, partially determine response to chemicals. An increased frequency of HLA-DR3 was found in one CFS study but not others.)














