#hyperexcitability

[osteogenesiscongenita]

Trousseau's Sign

Trousseau's Sign of Latent Tetany is a graceful wrist flexion with extension at the DIP and PIP joints and adduction of the fingers.  It can be elicited in patients with hyperreflexia or hyperexcitability due most often to hypocalcemia.  

Trousseau sign is far preferred over the Chvostek sign (which is only elicited in 25% of patients with tetany due to hypocalcemia or hypomagnesemia) and so the face tapping of the Chvostek is often dismissed in favor of the the lilting wrist flexing Trousseau induced by BP cuff occluding the brachial artery despite how overtly effeminate the result.

vs

[cfsfmmcsandrelatedstudies]

Mast Cells, Hyperexcitability, & Pre- vs Post-Treatment: Activation of esophageal mast cells leads to histamine release and, "a pronounced and long-lived increase in nociceptive C-fiber excitability." "This effect could be prevented by the histamine H1 receptor antagonist pyrilamine, but once the increase in excitability occurred, it persisted in the nominal absence of histamine and could not be reversed even with large concentrations of the histamine receptor antagonist." (Yu et al.)