#histamine

[sisterskaoi]

The good news: I got my ADHD diagnosis a few weeks ago! There's even a medication not incompatible with my current regime & diagnosed comorbidities, Clonidine!

The bad news: took my first half-tablet dose of Clonidine last night and it spiked my histamine so strongly and triggered such intense itchiness & hot flushes that even after taking 2 different antihistamines, I didn't "get to sleep" so much as "passed out from sheer exhaustion" for 4 hours.

The good news: despite only 4 hours of sleep, I have considerably less brain fog this morning and was able to do some reading on Clonidine, histamine, and ADHD interactions.

The bad news: it sure looks like I get to choose between treating my ADHD symptoms, or treating my inflammatory symptoms! I sure love being able to think but I sure don't love being SO FUCKING ITCHY.

@thebibliosphere why is it always histamine and mast cells?! Does your ADHD have to go untreated because of the MCAS?

[be-sketchy]

I went to the allergist today who specializes in MCAS and got diagnosed :,)

He could tell I was extremely nervous, I have a history of bad experiences and dismissal and was afraid it would happen here.

He wanted me to start from the very beginning of my health journey and he didn’t interrupt except to tell me that things were okay and to take my time.

He did some allergy tests and they came back negative.

He then sat me down and said “it’s not all in your head but Im about to give you allot of information” and I genuinely thought he was about to tell me it was anxiety and I almost cried

He then went on explaining MCAS to me fully, treatment plans, the different types. When he got to the criteria, the first part was severe recurrent symptoms involving two or more organs. Which I have everyday several times a day depending on triggers. This man literally looked at me and said “you are really sick”. His exact words.

I’m in a weird spot now, I’m so happy to finally have answers that make sense and a treatment plan, and that someone validated the way I felt and didn’t make me feel like shit for being anxious. I’m happy to hopefully get my life back and maybe my hopes and dreams I’ve put aside I can finally do again. I hope it will help me be a good wife who can do all the things he fell in love with when we first met.

But I’m also sad for all the time I’ve lost. Maybe I’d be achieving all my goals and dreams now if I’d been diagnosed then. Angry at my past coworker who didn’t listen to me when I told her she had covid, which led me to getting it then being sick since then. I’m also anxious that this is all in my head, maybe I’ve created an echo chamber of symptoms for myself. Or this is another misdiagnosis and it’s all wrong.

Idk mixed feelings

[iamemeraldfox]

Health update 7.2.2026

I've eliminated gluten and milk from my diet, except for small amounts for convenience. I am now gluten and milk free for 7 days, and can already measure the results with my Oura ring

You can see that my Readiness score, calculated during sleep, varies in the range of 68-86

Now it hovers around 90, yesterday up to 92!

The bad news is, hazel trees started to produce pollen, and today 7.2.2026 I've detected it for the first time this year. There was a telltale tingling and burning in my sinuses

I took a dose of antihistamines and DAO

Also, I found an interesting article about DAO (it mentiones non-IgE allergies, which is what I have)

DAO Deficiency May Explain Symptoms in Adults With Negative Food Allergy Tests | Docwire News

Most adults with self-reported food allergies tested negative, but 38% had low DAO, suggesting histamine intolerance.

Screenshots of the websites under the cut, to keep this post short

[journiland]

Note to self that I want to order a DAO enzyme supplement (breaks down histamine) when I'm not on a No-Spend month.

[incorrect-immunology-facts]

Is it just me or is histamine just histidine with the carboxyl group taken off? Like, it’s not subtle, girl, we can tell.

[krisrisk]

I hate how everything i have an appetite for is currently hurting me in the sense that it is all full of histamine, which makes my body overreact completely to mosquito bites.

And because i can't afford the meds currently, i am spending my evenings and nights scratching the itches, because even the tiniest bite becomes a huge fucking thing, swollen and red AND NOT GOING AWAY.

And everything i feel a desire to eat has even more of this stupid histamine in it, so it's not getting better.

[writer-at-the-table]

I strongly suspect that if you made a venn diagram of type 2 diabetes friendly foods, ibs friendly foods, and low histamine/histamine sensitivity safe foods, you would end up with very little in that center overlap

Which is making my life increasingly annoying and difficult right now

[covid-safer-hotties]

The histamine receptor H1 acts as an alternative receptor for SARS-CoV-2

ABSTRACT

Numerous host factors, in addition to human angiotensin-converting enzyme 2 (hACE2), have been identified as coreceptors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), demonstrating broad viral tropism and diversified druggable potential. We and others have found that antihistamine drugs, particularly histamine receptor H1 (HRH1) antagonists, potently inhibit SARS-CoV-2 infection. In this study, we provided compelling evidence that HRH1 acts as an alternative receptor for SARS-CoV-2 by directly binding to the viral spike protein. HRH1 also synergistically enhanced hACE2-dependent viral entry by interacting with hACE2. Antihistamine drugs effectively prevent viral infection by competitively binding to HRH1, thereby disrupting the interaction between the spike protein and its receptor. Multiple inhibition assays revealed that antihistamine drugs broadly inhibited the infection of various SARS-CoV-2 mutants with an average IC50 of 2.4 µM. The prophylactic function of these drugs was further confirmed by authentic SARS-CoV-2 infection assays and humanized mouse challenge experiments, demonstrating the therapeutic potential of antihistamine drugs for combating coronavirus disease 19.

Check out our archive for more:

The histamine receptor H1 acts as an alternative receptor for SARS-CoV-2 - Published July 2, 2024 ABSTRACT Numerous host fact