#immune refocusing

[didanawisgi]

BREAKING STUDY — COVID-19 mRNA Injections Dangerously Reprogram the Immune System, Increasing Infection Risk

More mRNA doses → more IgG4 (↑11x) → higher risk of infection (↑1.8x)

[didanawisgi]

Post-vaccination IgG4 and IgG2 class switch associates with increased risk of SARS-CoV-2 infections

Repeated COVID-19 mRNA vaccinations increase SARS-CoV-2 IgG4 antibodies, indicating extensive IgG class switching following the first booste

Highlights

• IgG4 and IgG2 levels increase markedly after the third mRNA dose against SARS-CoV-2.

• Elevated IgG4 levels after booster vaccination associate with an increased risk of infections.

• Increased non-cytophilic to cytophilic antibody ratio correlates with reduced functionality.

Abstract

Objectives

Repeated COVID-19 mRNA vaccinations increase SARS-CoV-2 IgG4 antibodies, indicating extensive IgG class switching following the first booster dose. This shift in IgG subclasses raises concerns due to the limited ability of IgG4 to mediate Fc-dependent effector functions.

Methods

To assess the impact of IgG4 induction on protective immunity, we analyzed longitudinal SARS-CoV-2 IgG subclasses, C1q and FcγR responses, and neutralizing activity in a well-characterized cohort of healthcare workers in Spain.

Results

Elevated IgG4 levels and higher ratios of non-cytophilic to cytophilic antibodies after booster vaccination were significantly associated with an increased risk of breakthrough infections (IgG4 HR[10-fold increase]=1.8, 95% CI=1.2–2.7; non-cytophilic to cytophilic ratio HR[10-fold increase]=1.5, 95% CI=1.1–1.9). Moreover, an increased non-cytophilic to cytophilic antibody ratio correlated with reduced functionality, including neutralization.

Conclusions

These findings suggest a potential association between IgG4 induction by mRNA vaccination and a higher risk of breakthrough infection, warranting further investigation into vaccination strategies to ensure sustained protection.

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Cleveland Clinic conclusively proves COVID Vaccines progressively destroy the Immune System

Here is the USnews.com 2022-2023 Best US Hospitals Honour Roll 1. Mayo Clinic, Rochester, Minnesota.2. Cedars-Sinai Medical Center, Los Ange

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Are SARS-CoV-2 virus levels in wastewater increasing again?

Are SARS-CoV-2 virus levels in wastewater increasing again? Have a look at the SARS-CoV-2 virus concentration in wastewater samples (USA): h

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Mass Vaccination + Viral Mutation

Mass vaccination and viral mutation — what’s their relationship? Geert Vanden Bossche, Ph.D., DVM, explains the mechanisms by which injectin

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Is Geert's Prediction of a Deadlier Covid Variant Coming True?

Excess deaths jump to 20-36% above normal. Does Covid cause delayed deaths that we miss?

Is Geert's Prediction of a Deadlier Covid Variant Coming True? Excess deaths jump to 20-36% above normal. Does Covid cause delayed deaths that we miss?

SUMMARY: Excess mortality in Europe has been elevated at about 15% since last spring. In December 2022, excess deaths frighteningly jumped to 30-35% above normal. Even Sweden, which avoided excess mortality in most of 2022, had 20% more deaths than expected in December. Has the vaccine-selected deadly Covid variant predicted by Geert Vanden Bossche finally arrived?

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Original Antigenic Sin Hits the Mainstream

WSJ catching up again