#immunoediting

[kamalkafir-blog]

Respiratory viral infections awaken metastatic breast cancer cells in lungs

Mouse strains, influenza infection and antibody treatments Transgenic mouse models of breast cancer, using mouse mammary tumour virus (MMTV) long terminal repeats, are widely used. In brief, MMTV-PyMT and MMTV-erbB2/neu/Her2 (MMTV-Her2) mice express the oncogenes polyoma virus middle T antigen (PyMT) and rat Erbb2 (encoding HER2), respectively, upstream of the MMTV promoter, which confers…

[dr-afsaeed]

Suppression of multiple mouse models of refractory malignancies by reprogramming IL-18 ligand-receptor interaction

Suppression of multiple mouse models of refractory malignancies by reprogramming IL-18 ligand-receptor interaction Summary Researchers developed a novel immunotherapeutic strategy that reprograms the IL-18 pathway to combat refractory malignancies in mice. By engineering a “decoy” IL-18 binding protein (IL-18BP), they were able to effectively suppress tumor growth across several mouse models of…

[larryhbernsteinme]

Immunoediting can be a constant defense in the cancer landscape

Immunoediting can be a constant defense in the cancer landscape

Reporter and Curator: Dr. Sudipta Saha, Ph.D.

  There are many considerations in the cancer immunoediting landscape of defense and regulation in the cancer hallmark biology. The cancer hallmark biology in concert with key controls of the HLA compatibility affinity mechanisms are pivotal in architecting a unique patient-centric therapeutic application. Selection of random immune products including…

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