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PF-05387252
PF-05387252 CAS 1604034-71-0 C25H27N5O2 MW 429.51418 g/mol 2-methoxy-3-[3-(4-methylpiperazin-1-yl)propoxy]-11H-indolo[3,2-c]quinoline-9-carbonitrile IRAK4 inhibitor Rheumatoid arthritis; SLE Preclinical In the past decade there has been considerable interest in targeting the innate immune system in the treatment of autoimmune diseases and sterile inflammation. Receptors of the innate immune…
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PF-05388169
PF-05388169 CAS 1604034-78-7, MF C22 H21 N3 O4 MW 391.42 11H-Indolo[3,2-c]quinoline-9-carbonitrile, 2-methoxy-3-[2-(2-methoxyethoxy)ethoxy]- IRAK4 inhibitor Rheumatoid arthritis; SLE Preclinical PAPER Bioorganic & Medicinal Chemistry Letters (2014), 24(9), 2066-2072. http://www.sciencedirect.com/science/article/pii/S0960894X14002832 Identification and optimization of indolo[2,3-c]quinoline…
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PF-05388169
PF-05388169
CAS 1604034-78-7, MF C22 H21 N3 O4
MW 391.42
11H-Indolo[3,2-c]quinoline-9-carbonitrile, 2-methoxy-3-[2-(2-methoxyethoxy)ethoxy]- IRAK4 inhibitor
Rheumatoid arthritis; SLE
Preclinical
PAPER
Bioorganic & Medicinal Chemistry Letters (2014), 24(9), 2066-2072.
http://www.sciencedirect.com/science/article/pii/S0960894X14002832
Identification and optimization of…
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PF-05387252
PF-05387252
CAS 1604034-71-0
C25H27N5O2 MW 429.51418 g/mol
2-methoxy-3-[3-(4-methylpiperazin-1-yl)propoxy]-11H-indolo[3,2-c]quinoline-9-carbonitrile
IRAK4 inhibitor
Rheumatoid arthritis; SLE
Preclinical
In the past decade there has been considerable interest in targeting the innate immune system in the treatment of autoimmune diseases and sterile inflammation. Receptors of the innate…
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PF-05387552
PF-05387552 IRAK4 CAS 1604034-71-0 C25 H27 N5 O2 11H-Indolo[3,2-c]quinoline-9-carbonitrile, 2-methoxy-3-[3-(4-methyl-1-piperazinyl)propoxy]- 2-methoxy-3-[3-(4-methylpiperazin-1-yl)propoxy]-11H-indolo[3,2-c]quinoline-9-carbonitrile Molecular Weight429.51 Molecular Formula: C25H27N5O2 Molecular Weight: 429.51418 g/mol Synthesis PAPER Bioorganic & Medicinal Chemistry…
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