Fujiko Mine's silent hill damage?
So, here's the interesting thing. Silent Hill seems to have a minimal impact on those who are perceived to be guiltless. Like, for all the troubles and annoyances Laura causes, she escapes "Silent Hill 2" fearless and unscathed. Members of The Order seem to be pretty well off too, but that may be more them being chill with monsters than them generally being unaffected by supernatural specters judging them. Given Fujiko's rather shameless nature, she might actually be 100% okay in Silent Hill! About the only one I could see having problems would be the TWCFM interpretation of her character, and that may have more to do with psychedelic drugs and experiments getting her than any personal reflection.
Oddly enough, Fujiko herself could be a Silent Hill manifestation.
From what I understand about the original "Lupin the Third" manga, Fujiko was originally more of catch-all name for several women that Lupin encountered, rather than a single entity. How much you want to take that into account, well, that's solely up to you. Getting into that canon's a bit like jamming your arm in a backed-up toilet. But, it does give me ammo for the supposition that Fujiko, much like Mary/Maria, could be a construct made by Silent Hill to hound Lupin. In this case, she'd be more of a Legion or a multi-soul existing in one ever-changing form, rather than the fulfillment of a wish.
There's an argument that's half forming in my brain for why Jigen would then be justified in being put off by her, as well as some curiosity on why she's effective on Goemon if she's meant to be more of a tormentor for Lupin. I just can't quite shape it.