#john kendrew

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John Kendrew – Scientist of the Day

John Cowdery Kendrew, an English biochemist, was born Mar. 24, 1917, in Oxford.

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Max Perutz & John Kendrew, NOBEL PRIZE LECTURES, 11 December 1962.

Allan Cormack’ & Godfrey Hounsfield’, “Computed Tomography”, NOBEL PRIZE LECTURES, 8 December 1978 was the topic of an earlier blog post. Here I present: Max Perutz, “X-ray Analysis of Heamaglobin”; and, John Kendrew, “Myoglobin and the Structure of Proteins”, NOBEL PRIZE LECTURES, 11 December 1962. Hemoglobin is a protein normally in the blood at concentrations of 12-20 grams per deciliter. The…

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Sir John Cowdery Kendrew (1917-1997), British biochemist, crystallographer and Nobel laureate, with a model of the structure of myoglobin. Kendrew graduated from the University of Cambridge in 1939. After the war, he and Max Perutz studied the crystalline structure of the muscle protein myoglobin using X-ray diffraction techniques. Kendrew, elected a Fellow at Peterhouse College, adapted Perutz's method and by 1959 had identified the structure of myoglobin. Kendrew and Perutz shared the 1962 Nobel Prize in Physiology or Medicine for their work. Kendrew was knighted in 1974.

[bpod-bpod]

24 March 2014

Model Making

Balancing on this dense forest of poles are the beginnings to the first molecular model of a protein ever to be made. Representing single atoms, each little ball is located in exactly the right position. The man behind the model is John Cowdery Kendrew, who was born on this day in 1917. Together with biologist Max Perutz, he won the 1962 Nobel Prize in Chemistry for finding out the structure of two proteins using a method called X-ray crystallography. Though it’s essentially a type of microscopy that zooms in incredibly far, it’s tricky to use. Rather than creating a magnified picture, it produces a dotted pattern that scientists need to decipher. And to generate a clear pattern, the protein molecules need to be in a perfect crystal formation. Kendrew and Perutz cleverly accomplished both, and thereby pioneered a new level of understanding into the biomolecules that run life.

Written by Emma Bornebroek

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Image courtesy of the MRC Laboratory of Molecular Biology Any re-use of this image must be authorised by the LMB

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