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Quick journal club on IPSC anti-aging paper: cool, but outstanding questions

A new Cell paper from Juan Carlos Izpisua Berlmonte’s group has made headlines about anti-aging across the globe because it suggests that the four core induced pluripotent stem cell (IPSC) factors use by Shinya Yamanaka to make IPSC can reverse aging. I’ve pasted the graphical abstract from the paper below and done a quick journal club style overview based on a quick skim of the paper.

Graphical…

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#2014 stem cell conferences #Abad et al 2013 #anti-aging #Juan Carlos Izpisua Berlmonte #KLF4 #MYC #Oct4 #Progeria #Progeria treatment #SOX2 #stem cells aging #stem cells anti-aging #Yamanaka factors

Researchers at the UCSD report a simple, easily reproducible RNA-based method of generating human induced pluripotent stem cells (iPSCs).

#Science #human #iPSC #Klf4 #Oct4 #pluripotent #reprogram #RNA #Sox2 #stem cells

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