Marie d'Antioche was probably the eldest of the children of Raimond de Peiteus, younger son of Guilhèm IX, duc d'Aquitània and Felipa de Tolosa and Constance d’Antioche, daughter and only child of Bohémond II de Hauteville, prince d'Antioche and Alix de Jérusalem. When Constance was around four-years-old, her father died in battle with the Turks and her mother remarried in 1153 to Renaud de Châtillon, the second son of a minor nobleman from Bourgogne.
In August of 1159, Bertha von Sulzbach, the first wife of Manouēl I Komnēnos died and his only surviving child was a daughter. He expressed a desire to remarry to a noblewoman from one of the crusader states and Marie was one of the candidates along with Mélisende de Tripoli, daughter of Raymond II de Tripoli and Hodierne de Jérusalem. Mélisende seemed the favored candidate until the Byzantine envoys heard the rumors that Hodierne had been unfaithful to her husband and instead chose Marie as a bride. Mélisende's brother, Raymond III, was insulted at the slighting of his sister and attacked Cyprus, but the marriage of Marie and Manouēl proceeded regardless.
For years, their marriage was childless. Expecting to have no further children, Manouēl arranged for his daughter, Maria Porphyrogénnētē, to marry Árpád-ház Béla, the eldest son and heir of II. Géza magyar király and Euphrosyne of Kiev, who was most likely a great-granddaughter of Harold Godƿinson and Edith Swannesha. Much to everyone's surprise, though, on 10 September 1169, Marie gave birth to a son, Alexios II Komnēnos. Maria's engagement to Árpád-ház Béla was broken off and she later married Ranieri degli Aleramici di Monferrato, the brother of Guglielmo Lungaspada (first husband of Sibylle de Jérusalem), Corrado (second husband of Isabelle Ire de Jérusalem), and Alasia. Not long afterwards, Manouēl arranged for young Alexios to marry Agnès de France, daughter of Louis VII de France and Adèle de Champagne. Agnès was around eight at the time and sent for immediately. Despite her young age, the chronicler Willelmus Tyrensis claims that she and Alexios were fully married to each other.
Manouēl died in 1180 and Marie was officially a nun, but in reality, she served as regent for the young Alexios. Her closest advisor and rumored lover was another Alexios Komnēnos, who was the uncle of Maria Komnēnē, reine de Jérusalem. She and the elder Alexios were regarded as corrupt and incompetent and were accused of favoring Latins over Greeks. Her most stalwart enemy was her stepdaughter, Maria Porphyrogénnētē, and her husband, Raineri (who, ironically, was a Latin himself), who may have had designs on the throne.
In 1182, Maria Porphyrogénnētē made the colossal mistake of inviting Andrónikos I Komnēnós back to Constantinople. A cousin of the late Manouēl, Andrónikos had been exiled to the Crusader States in 1168 for refusing to recognize Maria and her then-betrothed Béla as the heirs. He had spent his time in exile seducing noblewoman there including Philippa d'Antioche (Marie's younger sister) and Theodōra Komnēnē, reine de Jérusalem (the widow of Baudouin III de Jérusalem). It does not seem to have occurred to Maria that her father had exiled Andrónikos for a reason and that reason was about to become abundantly clear. Andrónikos promptly marched on Constantinople, arrested Marie, and let the inhabitants massacre the Latins. Shortly after, Maria Porphyrogénnētē and Raineri were both poisoned by a eunuch, most likely on Andrónikos' orders who saw them as a threat to his new regime. What happened to Marie's advisor, the elder Alexios, is unclear, but it's probably fair to bet that Andrónikos either exiled or killed him.
Marie sent word for help to Árpád-ház Béla, now King of Hungary, who was married to her half-sister, Agnès d’Antioche , but he was unable to reach her in time. If anything, this actually hurt her, because Andrónikos promptly accused her of inciting Béla to attack Belgrade and Barancs in what are now Serbia. Andrónikos then forced young Alexios to sign his mother's death warrant, but found himself short on people willing to execute her. His son, also named Manouēl, refused, so she was either strangled or sewed up in a sack and then drowned. Young Alexios died the following year at the age of fourteen, most likely murdered. As for Andrónikos, he tried to cement his rule by marrying Alexios' young widow, Agnès, but he found his empire threatened by Árpád-ház Béla, Guillaume II of Sicily, and Kilij Arslan II and detested by most of his own citizens. His reign ended in 1185 when attempted to have his cousin, Isaakios II Angelos, arrested for treason. Instead, Isaakios seized power and gave Andrónikos to the adoring citizens of Constantinople, who proceeded to cut one of his hands off, tear his hair and teeth out, gouge out his eyes, douse him in boiling water, and then tear him apart.