Disc-Based Microfluidics for Differential Extraction #worldresearchawards#researchawards#fosawards
The Forensic Lab-on-a-Disc is an advanced centrifugal microfluidic platform designed to enhance sperm cell purification in forensic differential extraction workflows. By replacing the conventional sperm separation step, this technology significantly improves male DNA enrichment from mixed biological samples, particularly in challenging sexual assault evidence.
Using centrifugal force combined with dual-membrane tangential flow filtration (10 µm and 1 µm pore sizes), the system enables rapid (~6 minutes), semi-automated separation of sperm cells from epithelial lysates and debris. Optimization studies demonstrate improved male DNA ratio, reduced non-sperm DNA carryover, enhanced STR profiling accuracy, and minimized sample loss compared to conventional differential extraction methods.
The compact, multi-sample, and operator-independent design reduces processing time, variability, and contamination risks—offering a transformative advancement for accelerating forensic DNA analysis and improving evidentiary reliability in sexual assault investigations.
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