Limb-Girdle Muscular Dystrophy (LGMD) & Treatment?
Limb-girdle muscular dystrophy (LGMD) are a subset of genetically inherited conditions and gene mutations that progressively weakens voluntary skeletal muscles, generally those most proximal to the hip and shoulder girdles. Collectively, the many different constituents of Limb-Girdle Muscular Dystrophy rank as the fourth most common cause of genetically caused muscular atrophy (degeneration). (adsbygoogle = window.adsbygoogle || ).push({}); What Causes Limb-Girdle Muscular Dystrophy So what causes LGMD? The answer lies in your genes. Genes are the functional unit responsible for encoding the proteins that are the building blocks for all of life. This code however is far from perfect and are prone to mutations. When mistakes happen in the genes of an organism, this can lead to complications that may manifest themselves as disease. This is the case in LGMD. When genes that are responsible for muscle function mutate, proteins vital to normal muscle function, regulation, and repair will not form. Without these proteins, the muscle will lose functionality. The different types of Limb-Girdle Muscular Dystrophies are classified into two major groups based off their inheritance patterns. LGMD1 and LGMD2. LGMD1 types are inherited autosomal dominant and LGMD2 types are inherited autosomal recessive. Read the full article