#lipid a

[didanawisgi]

Thus similar to skin inoculation, intranasal delivery of LNPs leads to massive inflammation. Furthermore, the LNPs' inflammatory properties are not site-specific; and show a fast diffusion, dispersion and distribution rate in the (other) tissues.

The mRNA-LNP platform’s lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory

[didanawisgi]

Chemical structure of lipid A as found in E. coli[1]

Lipid A is a lipid component of an endotoxin held responsible for the toxicity of gram-negative bacteria. It is the innermost of the three regions of the lipopolysaccharide (LPS), also called endotoxin molecule, and its hydrophobic nature allows it to anchor the LPS to the outer membrane.[2] While its toxic effects can be damaging, the sensing of lipid A by the immune system may also be critical for the onset of immune responses to gram-negative infection, and for the subsequent successful fight against the infection.