This can be one of the most dangerous natal placements she can have, for men as well as women. The reason why is because the 12th house is directly connected with the native's subconscious and even unconscious, she can induce a lot of fear here.
Additionally, Lilith in the 12th [Ruled by murky Neptune/Pisces] is responsible for some of the darkest forms of sexuality, her influence may bring dreams of rape and other unwanted perversions-- this will be highly likely if there are hard aspects to her as well. Again, since house 12 is the traditional home of Neptune and Pisces, when Lilith merges with them she can invoke their obscure sides. The sides of them that are less glamourous and more fearsome-- I'm talking self-harm, addictions to alcohol, drugs, and even prescription medicines. The reason is simple; her presence in the subconscious parts of the mind might make the chart owners deeper thoughts unbearable. Very hard to manage. The native might spend copious amounts of time trying to subdue these thoughts if Lilith gets activated. When she is activated, she may radiate vicious thoughts and general negativity towards the individual’s mind. I’m not just talking about depression.Lilith tends to bring harsher sentiments as self-wrath, self-destruction, and other negative feelings. With men, this typically manifests as darker impulses towards females. Much of this is projected outward if provoked. This tends to be why many natives with this placement tend towards substance abuse. A way to escape the darker parts of their mind. Lilith in the 12th house is also fond of secrets, many times dangerous ones. An individual with Lilith in the 12th may know critical information about others, they’ll come across them very easily or hide very dark secrets of his own.My advice to you would be to look out for difficult aspects with Mars, Pluto or Saturn. In case you have them, refrain from substances and seek alternative ways of escapism. In addition, Neptune adversely aspected to Lilith can also act as a strong malefic. In such a situation, the individual may never even understand the problematic situations that Lilith can bring, because his mind is creating a world of illusion, far from reality.The one good thing about this placement for men is that it is a placement for popularity. Surprising? Yes, I know. The reason why is folks with Lilith in the 12th tend to abhor all things 12th house. As a result, they seek to surround themselves with people and environments where they will not be alone and succumb to the darker energies she can bring. 12th House Lilith natives don’t like restriction in a small place or circle of people, and this will make them be rather outgoing. When they are around a lot of people, they stop concentrating on their own fears. This can even be an automated psycho-therapy, that the native indirectly does to himself.I hope this brought you some insight, love. <3