1.What Is Methandriol Raw Powder? Methandriol is a steroid that is very similar to the prohormone 5-androdiol except that it is C-17 alpha alkylated and also esterified at both ends. It is present in combination with several other steroids especially those manufactured in Australia. In Dan Duchaine’s Underground Steroid handbook II, Duchaine postulated that methandriol enhanced the activity of any steroid used in combination with it. He stated that methandriol did this by binding very strongly to SHBG thereby knocking other steroids into the free and active state (similar to what has been described for mesterolone). Although methandriol does bind to SHBG, it does so fairly weakly and is not capable of knocking most steroids off.Methandriol is very prone to aromatization (like androdiol) and it has been suggested that it can bind directly to the estrogen receptor without the need for aromatization. When used with other aromatizing steroids, methandriol most likely occupies aromatase to the point that the other steroid is unable to be aromatized allowing it to stay free and active. While this sounds like a good idea at first, the excess estrogen that is produced by adding methandriol could lead to gynecomastia quickly. Methandriol has been found to be a potent inhibitor of 11-beta hydroxylase.This results in a buildup of deoxycorticosterone, a potent mineralocorticoid that elicits retention of sodium and water resulting in hypertension.A potentially disturbing aspect of the hypertension induced with methandriol was its apparent irreversibility.The inhibition of 11-beta hydroxylase reduces the production of cortisol and results in a reduction in the size of the adrenals, also known as adrenal atrophy, which can result in a state of acute adrenal insufficiency upon withdrawal of the use of steroids that inhibit 11-beta hydroxylase. #methandriol#methandriolpowder#methandriolrawpowder#methandriolrawmaterial#521-10-8#bodybuilding#steroidsrawmaterial#fitness#rawmaterial#anabolicsteroidsrawmaterial#