lung-disease-related mitochondria studies
Mitochondrial dysfunction is rapidly developing as a key pathological feature of early and persistent lung disease. In particular, mitochondria are emerging as central to the pathological processes and clinical phenotypes associated with a range of lung diseases.
Abnormal mitochondrial signaling plays an important role in many lung diseases:
Altered mitochondrial biogenesis and mitogenesis
Increased mtDNA mutations
Abnormal mitochondrial-derived signaling
Activation of mtDAMPs
Comprehending the molecular mechanisms that modulate mitochondrial processes in lung cells will allow for a better definition of the phenotypes and clinical manifestations associated with respiratory diseases and explore potential diagnostic and therapeutic targets.