(CAS 1576-35-8) Tosylhydrazine
Tosylhydrazine (CAS 1576-35-8) is a high-purity reagent manufactured for pharmaceutical, fine chemical, and research synthesis.
Chemical Overview
Tosylhydrazine, also known as p-toluenesulfonyl hydrazide, is an important sulfonyl hydrazine derivative. It is commonly utilized in organic transformations, particularly in reactions involving carbonyl compounds and nitrogen-based intermediates.
Molecular Formula: C₇H₁₀N₂O₂S
Molecular Weight: 186.23 g/mol
CAS Number: 1576-35-8
Appearance: White to off-white crystalline powder
Melting Point: ~114–118°C
Solubility: Soluble in organic solvents, slightly soluble in water
Key Properties
Tosylhydrazine is valued for its stability and reactivity, making it suitable for a wide range of chemical processes:
High purity and consistent quality
Excellent reactivity with aldehydes and ketones
Stable under standard storage conditions
Versatile intermediate for nitrogen-containing compounds
Applications in Pharmaceutical Industry
In the pharmaceutical sector, Tosylhydrazine is used as an important intermediate for synthesizing active pharmaceutical ingredients (APIs) and drug intermediates.
API synthesis and modification
Formation of hydrazone derivatives
Intermediate in heterocyclic compound synthesis
Used in research for drug discovery and development
Role in Organic and Fine Chemical Synthesis
Tosylhydrazine is widely applied in organic chemistry due to its ability to participate in various important reactions:
Wolff–Kishner reduction (via hydrazone formation)
Preparation of diazo compounds
Synthesis of nitrogen-containing organic molecules
Intermediate in specialty and fine chemicals
Industrial Applications
Its versatility makes Tosylhydrazine valuable across multiple industries:
Agrochemical intermediates
Dye and pigment manufacturing
Specialty chemical production
Polymer and material science research
Specifications
Typical quality specifications for Tosylhydrazine include:
Purity: ≥ 98%
Moisture Content: ≤ 0.5%
Melting Range: 114–118°C
Residue on Ignition: ≤ 0.1%
Storage and Handling
To maintain stability and quality:
Store in a cool, dry, and well-ventilated area
Keep container tightly closed
Protect from moisture and direct sunlight
Avoid exposure to strong oxidizing agents
Safety Information
While Tosylhydrazine is widely used in laboratories and industry, proper safety precautions are essential:
Use appropriate personal protective equipment (PPE)
Avoid inhalation and skin contact
Handle in a well-ventilated environment
Refer to the MSDS for detailed safety and hazard information
Conclusion
Tosylhydrazine (CAS No: 1576-35-8) is a highly valuable reagent in pharmaceutical, chemical, and research industries. Its excellent reactivity, stability, and broad application range make it an essential component in modern organic synthesis.