Methanesulfonamide CASNO:3144-09-0
Methanesulfonamide (CAS 3144-09-0) is a high-purity chemical used in pharmaceuticals and organic synthesis. Explore its properties, applications, and safety data.
Introduction
Methanesulfonamide (CAS No: 3144-09-0) is an important organic compound belonging to the sulfonamide family. It is widely used in chemical synthesis, pharmaceutical research, and industrial applications. Due to its unique structure and reactivity, Methanesulfonamide serves as a key intermediate in the development of various high-value chemical products.
Chemical Identification
Chemical Name: Methanesulfonamide
CAS Number: 3144-09-0
Molecular Formula: CH₅NO₂S
Molecular Weight: 95.12 g/mol
Synonyms:
Methanesulfonic amide
Methyl sulfonamide
Mesyl amide
Methanesulfonamide is considered the simplest member of sulfonic acid amides, making it highly valuable in organic chemistry research.
Physical and Chemical Properties
Methanesulfonamide exhibits stable physical and chemical characteristics:
Appearance: White to yellow crystalline solid
Melting Point: 85–89°C
Boiling Point: ~208°C (predicted)
Density: ~1.229 g/cm³
Solubility: Slightly soluble in methanol and DMSO
pKa: ~10.87
These properties make it suitable for controlled reactions in laboratory and industrial environments.
Synthesis of Methanesulfonamide
Methanesulfonamide is typically synthesized by:
Reaction of methanesulfonyl chloride with ammonia
Alternative methods include reduction or reactions involving sulfonyl azides
These synthesis routes are widely adopted in chemical manufacturing industries.
Applications and Uses
1. Pharmaceutical Industry
Methanesulfonamide plays a crucial role in drug development:
Used as a reagent in synthesizing medicinal compounds
Helps in producing derivatives like indole-based and pyrimidine-based molecules
2. Organic Synthesis
Acts as a nitrogen source in converting carboxylic acids into nitriles
Used in the preparation of advanced organic intermediates
3. Chemical Research
Widely used in reaction studies and ligand binding analysis
Important in designing biologically active molecules
4. Industrial Applications
Used in the production of specialty chemicals
Involved in the synthesis of brightening agents and other functional compounds
Safety and Handling
Methanesulfonamide should be handled with care:
Classified as an irritant
May cause irritation to eyes, skin, and respiratory system
Recommended precautions:
Wear protective gloves and clothing
Avoid inhalation and direct contact
Store in a dry, sealed container away from light
Storage Guidelines
Store at room temperature
Keep in a cool, dry, and well-ventilated area
Protect from moisture and direct sunlight
Conclusion
Methanesulfonamide CAS No: 3144-09-0 is a versatile and essential compound in modern chemistry. Its applications in pharmaceuticals, organic synthesis, and industrial processes make it a valuable intermediate for research and production. With stable properties and wide usability, Methanesulfonamide continues to play a significant role in advancing chemical innovations.