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Uric Acid formation : Purine Nucleotide Catabolism

Because nucleic acids are ubiquitous in cellular material, significant amounts are ingested in the diet. Nucleic acids are degraded in the digestive tract to nucleotides by various nucleases and phosphodiesterases. Nucleotides are then converted to nucleosides by base-specific nucleotidases and nonspecific phosphatases.

NMP + H2O –> Nucleoside + Pi